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    Lsg1 large 60S subunit nuclear export GTPase 1 [ Mus musculus (house mouse) ]

    Gene ID: 224092, updated on 22-May-2024

    Summary

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    Official Symbol
    Lsg1provided by MGI
    Official Full Name
    large 60S subunit nuclear export GTPase 1provided by MGI
    Primary source
    MGI:MGI:107236
    See related
    Ensembl:ENSMUSG00000022538 AllianceGenome:MGI:107236
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    5830465I20; D16Bwg1547e
    Summary
    Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in ribosomal subunit export from nucleus. Predicted to act upstream of or within protein transport. Predicted to be located in Cajal body and endoplasmic reticulum. Predicted to be active in cytosol. Orthologous to human LSG1 (large 60S subunit nuclear export GTPase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 13.9), limb E14.5 (RPKM 8.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Lsg1 in Genome Data Viewer
    Location:
    16 B2; 16 21.34 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (30380187..30406430, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (30561369..30587612, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene ATPase type 13A3 Neighboring gene STARR-positive B cell enhancer mm9_chr16:30374407-30374708 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:30389389-30389616 Neighboring gene STARR-seq mESC enhancer starr_40576 Neighboring gene STARR-seq mESC enhancer starr_40579 Neighboring gene STARR-seq mESC enhancer starr_40580 Neighboring gene transmembrane protein 44 Neighboring gene predicted gene, 52252 Neighboring gene STARR-seq mESC enhancer starr_40581 Neighboring gene STARR-seq mESC enhancer starr_40582 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:30587870-30588053 Neighboring gene predicted gene, 53946 Neighboring gene STARR-positive B cell enhancer ABC_E5536 Neighboring gene family with sequence similarity 43, member A Neighboring gene STARR-seq mESC enhancer starr_40586 Neighboring gene STARR-positive B cell enhancer ABC_E9928 Neighboring gene predicted gene, 49754

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Brady KP, et al. Genome Res, 1997 Nov. PMID 9371744, Free PMC Article
    2. Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics. Federspiel JD, et al. Mol Cell Proteomics, 2019 Aug 9. PMID 31040226, Free PMC Article
    3. Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders. Li J, et al. Nat Neurosci, 2017 Aug. PMID 28671696, Free PMC Article
    4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    5. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in nuclear export ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosomal subunit export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Cajal body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    large subunit GTPase 1 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001417028.1 → NP_001403957.1  large subunit GTPase 1 homolog isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC104885

    2. NM_001417029.1 → NP_001403958.1  large subunit GTPase 1 homolog isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC104885

    3. NM_001417030.1 → NP_001403959.1  large subunit GTPase 1 homolog isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC104885

    4. NM_001417031.1 → NP_001403960.1  large subunit GTPase 1 homolog isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC104885

    5. NM_178069.6 → NP_835170.1  large subunit GTPase 1 homolog isoform 1

      See identical proteins and their annotated locations for NP_835170.1

      Status: VALIDATED

      Source sequence(s)
      AC104885
      Consensus CDS
      CCDS37311.1
      UniProtKB/Swiss-Prot
      Q3UM18, Q68ED9, Q80V36
      Related
      ENSMUSP00000112860.3, ENSMUST00000117363.9
      Conserved Domains (2) summary
      cd01857
      Location:163 → 430
      HSR1_MMR1; A circularly permuted subfamily of the Ras GTPases
      COG1161
      Location:151 → 540
      RbgA; Ribosome biogenesis GTPase A [Translation, ribosomal structure and biogenesis]

    RNA

    1. NR_184411.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC104885

    2. NR_184412.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC104885

    3. NR_184413.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC104885

    4. NR_184414.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC104885

    5. NR_184415.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC104885
      Related
      ENSMUST00000143170.9

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      30380187..30406430 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_004939187.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UM18.2 GenPept UniProtKB/Swiss-Prot:Q3UM18

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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