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    TRIM34 tripartite motif containing 34 [ Homo sapiens (human) ]

    Gene ID: 53840, updated on 7-Apr-2024

    Summary

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    Official Symbol
    TRIM34provided by HGNC
    Official Full Name
    tripartite motif containing 34provided by HGNC
    Primary source
    HGNC:HGNC:10063
    See related
    Ensembl:ENSG00000258659 MIM:605684; AllianceGenome:HGNC:10063
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IFP1; RNF21
    Summary
    The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, B-box type 1 and B-box type 2 domain, and a coiled-coil region. Expression of this gene is up-regulated by interferon. This gene is mapped to chromosome 11p15, where it resides within a TRIM gene cluster. Alternative splicing results in multiple transcript variants. A read-through transcript from the upstream TRIM6 gene has also been observed, which results in a fusion product from these neighboring family members. [provided by RefSeq, Oct 2010]
    Expression
    Ubiquitous expression in spleen (RPKM 7.4), lymph node (RPKM 6.3) and 24 other tissues See more
    Orthologs
    all
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    Genomic context

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    See TRIM34 in Genome Data Viewer
    Location:
    11p15.4
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (5619944..5644398)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (5677835..5702296)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (5641174..5665628)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 4920 Neighboring gene olfactory receptor family 52 subfamily B member 6 Neighboring gene Sharpr-MPRA regulatory region 11830 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:5617638-5618555 Neighboring gene TRIM6-TRIM34 readthrough Neighboring gene Sharpr-MPRA regulatory region 4679 Neighboring gene tripartite motif containing 5 Neighboring gene tripartite motif containing 6 Neighboring gene NANOG hESC enhancer GRCh37_chr11:5642663-5643271 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4327 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4328 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4329 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4330 Neighboring gene uncharacterized LOC107984302 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr11:5700031-5701230 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4331 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:5711125-5712324 Neighboring gene uncharacterized LOC124902620 Neighboring gene tripartite motif containing 22

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. TRIM34 facilitates the formation of multinucleated giant cells by enhancing cell fusion and phagocytosis in epithelial cells. Sun D, et al. Exp Cell Res, 2019 Nov 1. PMID 31487507
    2. [Tripartite motif-containing protein 34 (TRIM34) colocalized with micronuclei chromosome and hampers its movement to equatorial plate during the metaphase stage of mitosis]. Sun D, et al. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 2016 Jun. PMID 27371841
    3. TRIM34 restricts HIV-1 and SIV capsids in a TRIM5α-dependent manner. Ohainle M, et al. PLoS Pathog, 2020 Apr. PMID 32282853, Free PMC Article
    4. Molecular cloning of ring finger protein 21 (RNF21)/interferon-responsive finger protein (ifp1), which possesses two RING-B box-coiled coil domains in tandem. Orimo A, et al. Genomics, 2000 Oct 1. PMID 11013086
    5. Binding of the rhesus TRIM5α PRYSPRY domain to capsid is necessary but not sufficient for HIV-1 restriction. Yang Y, et al. Virology, 2014 Jan 5. PMID 24314652, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TRIM34 suppresses non-small-cell lung carcinoma via inducing mTORC1-dependent glucose utilization and promoting cellular death.
      Title: TRIM34 suppresses non-small-cell lung carcinoma via inducing mTORC1-dependent glucose utilization and promoting cellular death.
    2. TRIM34 modulates influenza virus-activated programmed cell death by targeting Z-DNA-binding protein 1 for K63-linked polyubiquitination.
      Title: TRIM34 modulates influenza virus-activated programmed cell death by targeting Z-DNA-binding protein 1 for K63-linked polyubiquitination.
    3. TRIM34 restricts HIV-1 and SIV capsids in a TRIM5alpha-dependent manner.
      Title: TRIM34 restricts HIV-1 and SIV capsids in a TRIM5α-dependent manner.
    4. TRIM34 proteins contribute to the formation of MGCs.
      Title: TRIM34 facilitates the formation of multinucleated giant cells by enhancing cell fusion and phagocytosis in epithelial cells.
    5. Data show there was no distinguished colocalization relationship between the complex of tripartite motif-containing protein 34 (TRIM34)-micronulei and mitochondria.
      Title: [Tripartite motif-containing protein 34 (TRIM34) colocalized with micronuclei chromosome and hampers its movement to equatorial plate during the metaphase stage of mitosis].
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat specifically associates with TRIM34 promoter to upregulate TRIM34 expression in T cells PubMed
    capsid gag Human TRIM34 binds in vitro assembled HIV-1 CA-NC complexes PubMed
    gag The RING, B-box 2, and coiled-coil domains of TRIM34 can functionally replace the corresponding domains of rhesus monkey TRIM5alpha with respect to inhibition of HIV-1 infection through the binding of the chimeras to HIV-1 capsid complexes PubMed
    nucleocapsid gag Human TRIM34 binds in vitro assembled HIV-1 CA-NC complexes PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Readthrough TRIM6-TRIM34

    Readthrough gene: TRIM6-TRIM34, Included gene: TRIM6

    Homology

    Clone Names

    • MGC176399

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein homodimerization activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in defense response to virus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of NF-kappaB transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of autophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of canonical NF-kappaB signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of viral entry into host cell IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase TRIM34
    Names
    interferon-responsive finger protein 1
    ring finger protein 21, interferon-responsive
    NP_001003827.1
    NP_067629.2
    NP_569074.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003827.1 → NP_001003827.1  E3 ubiquitin-protein ligase TRIM34 isoform 1

      See identical proteins and their annotated locations for NP_001003827.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Both variants 1 and 4 encode the same isoform (1, also known as the middle form).
      Source sequence(s)
      AB039902, AF220144, BM989990
      Consensus CDS
      CCDS31391.1
      UniProtKB/Swiss-Prot
      D3DQS7, Q9BYJ4, Q9C016, Q9HCR0, Q9HCR1, Q9HCR2
      Related
      ENSP00000422947.1, ENST00000514226.5
      Conserved Domains (3) summary
      cd00021
      Location:95 → 132
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      cd15825
      Location:300 → 485
      SPRY_PRY_TRIM34; PRY/SPRY domain in tripartite motif-containing protein 34 (TRIM34), also known as RING finger protein 21 (RNF21) or interferon-responsive finger protein (IFP1)
      cl17238
      Location:15 → 59
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    2. NM_021616.6 → NP_067629.2  E3 ubiquitin-protein ligase TRIM34 isoform 1

      See identical proteins and their annotated locations for NP_067629.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1, also known as alpha) represents the longest transcript and encodes the longer isoform (1, also known as the middle form). Both variants 1 and 4 encode the same isoform.
      Source sequence(s)
      AF220143, BG682537, DB024660
      Consensus CDS
      CCDS31391.1
      UniProtKB/Swiss-Prot
      D3DQS7, Q9BYJ4, Q9C016, Q9HCR0, Q9HCR1, Q9HCR2
      Related
      ENSP00000402595.2, ENST00000429814.3
      Conserved Domains (3) summary
      cd00021
      Location:95 → 132
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      cd15825
      Location:300 → 485
      SPRY_PRY_TRIM34; PRY/SPRY domain in tripartite motif-containing protein 34 (TRIM34), also known as RING finger protein 21 (RNF21) or interferon-responsive finger protein (IFP1)
      cl17238
      Location:15 → 59
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    3. NM_130390.2 → NP_569074.2  E3 ubiquitin-protein ligase TRIM34 isoform 3

      See identical proteins and their annotated locations for NP_569074.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks several 3' exons but includes a unique segment at its 3' end, compared to variant 1. The encoded isoform (3, also known as the short form) has a distinct and shorter C-terminus, compared to isoform 1. The 5' UTR is incomplete due to a lack of 5'-complete transcripts representing this variant and the presence of splicing ambiguity in the 5' region.
      Source sequence(s)
      AB039902, DA847894
      UniProtKB/Swiss-Prot
      Q9BYJ4
      Related
      ENST00000491385.1
      Conserved Domains (2) summary
      cd00021
      Location:95 → 132
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      cl17238
      Location:15 → 59
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      5619944..5644398
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      5677835..5702296
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_130389.3: Suppressed sequence

      Description
      NM_130389.3: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9BYJ4.2 GenPept UniProtKB/Swiss-Prot:Q9BYJ4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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