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TRIM6-TRIM34 TRIM6-TRIM34 readthrough [ Homo sapiens (human) ]

Gene ID: 445372, updated on 5-Mar-2024

Summary

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Official Symbol
TRIM6-TRIM34provided by HGNC
Official Full Name
TRIM6-TRIM34 readthroughprovided by HGNC
Primary source
HGNC:HGNC:33440
See related
Ensembl:ENSG00000258588 AllianceGenome:HGNC:33440
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IFP1; RNF21; RNF89; TRIM6; TRIM34
Summary
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This gene represents a readthrough transcript from genes TRIM6 and TRIM34, and it was described as a splice variant of TRIM34. This gene is mapped to chromosome 11p15, where it resides within a TRIM gene cluster. [provided by RefSeq, Nov 2009]
Expression
Ubiquitous expression in spleen (RPKM 5.9), kidney (RPKM 5.3) and 24 other tissues See more
Orthologs
all
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Genomic context

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See TRIM6-TRIM34 in Genome Data Viewer
Location:
11p15.4
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (5596637..5644398)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (5656042..5702296)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (5617867..5665628)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 53 Neighboring gene Sharpr-MPRA regulatory region 4920 Neighboring gene olfactory receptor family 52 subfamily B member 6 Neighboring gene Sharpr-MPRA regulatory region 11830 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:5617638-5618555 Neighboring gene Sharpr-MPRA regulatory region 4679 Neighboring gene tripartite motif containing 5 Neighboring gene tripartite motif containing 6 Neighboring gene NANOG hESC enhancer GRCh37_chr11:5642663-5643271 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4327 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4328 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4329 Neighboring gene tripartite motif containing 34 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4330 Neighboring gene uncharacterized LOC107984302 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr11:5700031-5701230 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4331 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:5711125-5712324 Neighboring gene uncharacterized LOC124902620 Neighboring gene tripartite motif containing 22

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Molecular cloning of ring finger protein 21 (RNF21)/interferon-responsive finger protein (ifp1), which possesses two RING-B box-coiled coil domains in tandem. Orimo A, et al. Genomics, 2000 Oct 1. PMID 11013086
  2. Functional replacement of the RING, B-box 2, and coiled-coil domains of tripartite motif 5alpha (TRIM5alpha) by heterologous TRIM domains. Li X, et al. J Virol, 2006 Jul. PMID 16775307, Free PMC Article
  3. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. Prakash T, et al. PLoS One, 2010 Oct 12. PMID 20967262, Free PMC Article
  4. Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. Lauc G, et al. PLoS Genet, 2013. PMID 23382691, Free PMC Article
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. heterologous RING, B-box 2, and CC domains from related TRIM proteins can functionally substitute for TRIM5alpha(rh) domains.
    Title: Functional replacement of the RING, B-box 2, and coiled-coil domains of tripartite motif 5alpha (TRIM5alpha) by heterologous TRIM domains.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
EBI GWAS Catalog

Variation

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See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

General protein information

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Preferred Names
tripartite motif-containing 6 and tripartite motif-containing 34
Names
RING finger protein 21
RING finger protein 89
RING-type E3 ubiquitin transferase TRIM6
Tripartite motif-containing protein 34
Tripartite motif-containing protein 6
interferon-responsive finger protein 1 long form

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003819.4 → NP_001003819.1  tripartite motif-containing 6 and tripartite motif-containing 34

    See identical proteins and their annotated locations for NP_001003819.1

    Status: VALIDATED

    Source sequence(s)
    AB039903, AC015691, BC140722
    UniProtKB/TrEMBL
    B2RNG4
    Related
    ENSP00000346916.5, ENST00000354852.5
    Conserved Domains (5) summary
    smart00336
    Location:121 → 161
    BBOX; B-Box-type zinc finger
    cd00021
    Location:449 → 486
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    cd15825
    Location:654 → 839
    SPRY_PRY_TRIM34; PRY/SPRY domain in tripartite motif-containing protein 34 (TRIM34), also known as RING finger protein 21 (RNF21) or interferon-responsive finger protein (IFP1)
    cd16591
    Location:40 → 89
    RING-HC_TRIM5_like-C-IV; RING finger, HC subclass, found in tripartite motif-containing proteins TRIM5, TRIM6, TRIM22, TRIM34 and similar proteins
    cl25602
    Location:177 → 270
    DUF3552; Domain of unknown function (DUF3552)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    5596637..5644398
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    5656042..5702296
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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