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    Ccdc125 coiled-coil domain containing 125 [ Mus musculus (house mouse) ]

    Gene ID: 76041, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Ccdc125provided by MGI
    Official Full Name
    coiled-coil domain containing 125provided by MGI
    Primary source
    MGI:MGI:1923291
    See related
    Ensembl:ENSMUSG00000048924 AllianceGenome:MGI:1923291
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    5830436D01Rik
    Summary
    Predicted to enable identical protein binding activity. Predicted to be involved in activation of GTPase activity; negative regulation of Rho protein signal transduction; and negative regulation of cell motility. Predicted to be active in cytoplasm. Orthologous to human CCDC125 (coiled-coil domain containing 125). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in liver E18 (RPKM 2.6), bladder adult (RPKM 2.3) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ccdc125 in Genome Data Viewer
    Location:
    13 D1; 13 53.23 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (100805442..100833748)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (100668934..100697240)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene RAD17 checkpoint clamp loader component Neighboring gene STARR-positive B cell enhancer ABC_E7268 Neighboring gene TATA-box binding protein associated factor 9 Neighboring gene adenylate kinase 6 Neighboring gene STARR-seq mESC enhancer starr_35476 Neighboring gene cyclin dependent kinase 7 Neighboring gene STARR-seq mESC enhancer starr_35477 Neighboring gene STARR-positive B cell enhancer ABC_E7269 Neighboring gene STARR-positive B cell enhancer mm9_chr13:101513935-101514236 Neighboring gene mitochondrial ribosomal protein S36 Neighboring gene centromere protein H

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Role of Kenae/CCDC125 in cell motility through the deregulation of RhoGTPase. Araya N, et al. Int J Mol Med, 2009 Nov. PMID 19787194
    2. Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo. Harrison SM, et al. Development, 1995 Aug. PMID 7671812
    3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    4. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in activation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of Rho protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of Rho protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell motility IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of cell motility ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell motility IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    coiled-coil domain-containing protein 125

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001168386.2 → NP_001161858.1  coiled-coil domain-containing protein 125 isoform B

      See identical proteins and their annotated locations for NP_001161858.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (B) lacks an in-frame exon in the 5' coding region and an exon in the 3' coding region, which results in a frameshift, compared to variant A. The resulting protein (isoform B) is shorter and has a distinct C-terminus, compared to isoform A.
      Source sequence(s)
      AC165159, AK017973
      Consensus CDS
      CCDS49346.1
      UniProtKB/TrEMBL
      G3UWA1
      Related
      ENSMUSP00000130107.3, ENSMUST00000170347.4
      Conserved Domains (1) summary
      COG1196
      Location:105 → 226
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    2. NM_183115.5 → NP_898938.4  coiled-coil domain-containing protein 125 isoform A

      See identical proteins and their annotated locations for NP_898938.4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (A) represents the longer transcript and encodes the longer isoform (A).
      Source sequence(s)
      AC165159
      Consensus CDS
      CCDS26736.1
      UniProtKB/Swiss-Prot
      E9QPT5, Q5U465, Q8CEN7
      Related
      ENSMUSP00000058484.8, ENSMUST00000057325.15
      Conserved Domains (1) summary
      COG1196
      Location:83 → 429
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      100805442..100833748
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011244703.3 → XP_011243005.1  coiled-coil domain-containing protein 125 isoform X2

      See identical proteins and their annotated locations for XP_011243005.1

      UniProtKB/Swiss-Prot
      E9QPT5, Q5U465, Q8CEN7
      Conserved Domains (1) summary
      COG1196
      Location:83 → 429
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    2. XM_017315630.2 → XP_017171119.2  coiled-coil domain-containing protein 125 isoform X1

      Conserved Domains (1) summary
      COG1196
      Location:116 → 462
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    3. XM_011244704.1 → XP_011243006.1  coiled-coil domain-containing protein 125 isoform X2

      See identical proteins and their annotated locations for XP_011243006.1

      UniProtKB/Swiss-Prot
      E9QPT5, Q5U465, Q8CEN7
      Conserved Domains (1) summary
      COG1196
      Location:83 → 429
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    4. XM_011244705.1 → XP_011243007.1  coiled-coil domain-containing protein 125 isoform X2

      See identical proteins and their annotated locations for XP_011243007.1

      UniProtKB/Swiss-Prot
      E9QPT5, Q5U465, Q8CEN7
      Conserved Domains (1) summary
      COG1196
      Location:83 → 429
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    5. XM_036158215.1 → XP_036014108.1  coiled-coil domain-containing protein 125 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5U465.2 GenPept UniProtKB/Swiss-Prot:Q5U465

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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