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Conserved domains on  [gi|270288750|ref|NP_001161858|]
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coiled-coil domain-containing protein 125 isoform B [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRRFIP super family cl26610
LRRFIP family; LRRFIP1 is a transcriptional repressor which preferentially binds to the ...
 83-194 5.71e-03

LRRFIP family; LRRFIP1 is a transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'- AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. LRRFIP2 may function as activator of the canonical Wnt signalling pathway, in association with DVL3, upstream of CTNNB1/beta-catenin.


The actual alignment was detected with superfamily member pfam09738:

Pssm-ID: 462869 [Multi-domain]  Cd Length: 303  Bit Score: 38.14  E-value: 5.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288750   83 TSAEGYRASRLSSTDSNSELSDEQLRRRLHEALEDVE-------ILKTELEASQRQLEGKEEALK-ILQSMEINALQWEM 154
Cdd:pfam09738  63 LNSLGGTSSRRSSEDSSISLEDEGSLRDIKHELKEVEekyrkamISNAQLDNEKSNLMYQVDLLKdKLEEMEESLAELQR 142

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 270288750  155 EFDQdrfKNIE-ESWIQKCDRLNCDNAVLRENLKLRTEEIK 194
Cdd:pfam09738 143 ELRE---KNKElERLKRNLRRLQFQLAELKEQLKQRDELIE 180
 
Name Accession Description Interval E-value
LRRFIP pfam09738
LRRFIP family; LRRFIP1 is a transcriptional repressor which preferentially binds to the ...
 83-194 5.71e-03

LRRFIP family; LRRFIP1 is a transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'- AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. LRRFIP2 may function as activator of the canonical Wnt signalling pathway, in association with DVL3, upstream of CTNNB1/beta-catenin.


Pssm-ID: 462869 [Multi-domain]  Cd Length: 303  Bit Score: 38.14  E-value: 5.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288750   83 TSAEGYRASRLSSTDSNSELSDEQLRRRLHEALEDVE-------ILKTELEASQRQLEGKEEALK-ILQSMEINALQWEM 154
Cdd:pfam09738  63 LNSLGGTSSRRSSEDSSISLEDEGSLRDIKHELKEVEekyrkamISNAQLDNEKSNLMYQVDLLKdKLEEMEESLAELQR 142

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 270288750  155 EFDQdrfKNIE-ESWIQKCDRLNCDNAVLRENLKLRTEEIK 194
Cdd:pfam09738 143 ELRE---KNKElERLKRNLRRLQFQLAELKEQLKQRDELIE 180
 
Name Accession Description Interval E-value
LRRFIP pfam09738
LRRFIP family; LRRFIP1 is a transcriptional repressor which preferentially binds to the ...
 83-194 5.71e-03

LRRFIP family; LRRFIP1 is a transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'- AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. LRRFIP2 may function as activator of the canonical Wnt signalling pathway, in association with DVL3, upstream of CTNNB1/beta-catenin.


Pssm-ID: 462869 [Multi-domain]  Cd Length: 303  Bit Score: 38.14  E-value: 5.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288750   83 TSAEGYRASRLSSTDSNSELSDEQLRRRLHEALEDVE-------ILKTELEASQRQLEGKEEALK-ILQSMEINALQWEM 154
Cdd:pfam09738  63 LNSLGGTSSRRSSEDSSISLEDEGSLRDIKHELKEVEekyrkamISNAQLDNEKSNLMYQVDLLKdKLEEMEESLAELQR 142

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 270288750  155 EFDQdrfKNIE-ESWIQKCDRLNCDNAVLRENLKLRTEEIK 194
Cdd:pfam09738 143 ELRE---KNKElERLKRNLRRLQFQLAELKEQLKQRDELIE 180
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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