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    Elac1 elaC ribonuclease Z 1 [ Mus musculus (house mouse) ]

    Gene ID: 114615, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Elac1provided by MGI
    Official Full Name
    elaC ribonuclease Z 1provided by MGI
    Primary source
    MGI:MGI:1890495
    See related
    Ensembl:ENSMUSG00000036941 AllianceGenome:MGI:1890495
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2610018O07Rik; 8430417G19Rik
    Summary
    Predicted to enable 3'-tRNA processing endoribonuclease activity. Predicted to be involved in tRNA 3'-trailer cleavage. Predicted to act upstream of or within tRNA processing. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Orthologous to human ELAC1 (elaC ribonuclease Z 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 4.6), frontal lobe adult (RPKM 3.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Elac1 in Genome Data Viewer
    Location:
    18 E2; 18 49.83 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (73868109..73887589, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (73735038..73754519, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_44993 Neighboring gene predicted gene, 32548 Neighboring gene EGF-like domain 7 pseudogene Neighboring gene malic enzyme 2, NAD(+)-dependent, mitochondrial Neighboring gene STARR-positive B cell enhancer ABC_E11003 Neighboring gene predicted gene, 52346

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A candidate prostate cancer susceptibility gene at chromosome 17p. Tavtigian SV, et al. Nat Genet, 2001 Feb. PMID 11175785
    2. Transposon mutagenesis with coat color genotyping identifies an essential role for Skor2 in sonic hedgehog signaling and cerebellum development. Wang B, et al. Development, 2011 Oct. PMID 21937600, Free PMC Article
    3. Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA. Liu X, et al. BMC Immunol, 2016 Aug 2. PMID 27480124, Free PMC Article
    4. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3'-tRNA processing endoribonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA endonuclease activity, producing 5'-phosphomonoesters IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA-specific ribonuclease activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in rescue of stalled ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tRNA 3'-end processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc phosphodiesterase ELAC protein 1
    Names
    RNase Z 1
    elaC homolog 1
    elaC homolog protein 1
    ribonuclease Z 1
    tRNA 3 endonuclease 1
    tRNase Z 1
    NP_444485.2
    XP_030106136.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053255.3 → NP_444485.2  zinc phosphodiesterase ELAC protein 1

      See identical proteins and their annotated locations for NP_444485.2

      Status: VALIDATED

      Source sequence(s)
      AC132418, AF308697, AK018424, BY286576, CV556353
      Consensus CDS
      CCDS37855.1
      UniProtKB/Swiss-Prot
      Q8VEB6, Q9CXB1, Q9ERF4
      Related
      ENSMUSP00000041793.3, ENSMUST00000041138.3
      Conserved Domains (2) summary
      COG1234
      Location:3 → 359
      ElaC; Ribonuclease BN, tRNA processing enzyme [Translation, ribosomal structure and biogenesis]
      TIGR02651
      Location:4 → 358
      RNase_Z; ribonuclease Z

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      73868109..73887589 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030250276.2 → XP_030106136.1  zinc phosphodiesterase ELAC protein 1 isoform X1

      Conserved Domains (1) summary
      cd07717
      Location:5 → 195
      RNaseZ_ZiPD-like_MBL-fold; Ribonuclease Z, E. coli 3' tRNA-processing endonuclease ZiPD and related proteins; MBL-fold metallo-hydrolase domain

    RNA

    1. XR_385970.5 RNA Sequence

    2. XR_003952490.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VEB6.1 GenPept UniProtKB/Swiss-Prot:Q8VEB6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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