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    Skint4 selection and upkeep of intraepithelial T cells 4 [ Mus musculus (house mouse) ]

    Gene ID: 320640, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Skint4provided by MGI
    Official Full Name
    selection and upkeep of intraepithelial T cells 4provided by MGI
    Primary source
    MGI:MGI:2444425
    See related
    Ensembl:ENSMUSG00000055960 AllianceGenome:MGI:2444425
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    9530098N22Rik
    Summary
    Predicted to enable signaling receptor binding activity. Predicted to be involved in T cell receptor signaling pathway and regulation of cytokine production. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in external side of plasma membrane. Is expressed in appendicular skeleton; heart ventricle; skin; and thymus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See Skint4 in Genome Data Viewer
    Location:
    4 D1; 4 51.53 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (111929213..112025273)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (112072016..112168076)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene selection and upkeep of intraepithelial T cells 7 Neighboring gene selection and upkeep of intraepithelial T cells 1 Neighboring gene STARR-seq mESC enhancer starr_11099 Neighboring gene selection and upkeep of intraepithelial T cells 3 Neighboring gene selection and upkeep of intraepithelial T cells 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Skint1, the prototype of a newly identified immunoglobulin superfamily gene cluster, positively selects epidermal gammadelta T cells. Boyden LM, et al. Nat Genet, 2008 May. PMID 18408721, Free PMC Article
    2. The splicing regulators Esrp1 and Esrp2 direct an epithelial splicing program essential for mammalian development. Bebee TW, et al. Elife, 2015 Sep 15. PMID 26371508, Free PMC Article
    3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in T cell receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cytokine production IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    selection and upkeep of intraepithelial T-cells protein 4
    Names
    skint 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347180.1 → NP_001334109.1  selection and upkeep of intraepithelial T-cells protein 4 isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AL831778
      Consensus CDS
      CCDS84779.1
      UniProtKB/Swiss-Prot
      A7TZF3, A7TZF4
      Related
      ENSMUSP00000102175.2, ENSMUST00000106565.8

    2. NM_001357339.1 → NP_001344268.1  selection and upkeep of intraepithelial T-cells protein 4 isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AK028550, AK028795, EF494898
      Conserved Domains (2) summary
      cd05713
      Location:49 → 148
      Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
      cl11960
      Location:160 → 249
      Ig; Immunoglobulin domain

    3. NM_178786.4 → NP_848901.2  selection and upkeep of intraepithelial T-cells protein 4 isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK028795, AK035748, AK162813
      Consensus CDS
      CCDS38837.1
      UniProtKB/TrEMBL
      E9QLU2
      Related
      ENSMUSP00000102176.2, ENSMUST00000106566.2
      Conserved Domains (2) summary
      cd05713
      Location:49 → 148
      Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
      smart00410
      Location:41 → 147
      IG_like; Immunoglobulin like

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      111929213..112025273
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A7TZF3.1 GenPept UniProtKB/Swiss-Prot:A7TZF3

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