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    TENM1 teneurin transmembrane protein 1 [ Homo sapiens (human) ]

    Gene ID: 10178, updated on 3-Apr-2024

    Summary

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    Official Symbol
    TENM1provided by HGNC
    Official Full Name
    teneurin transmembrane protein 1provided by HGNC
    Primary source
    HGNC:HGNC:8117
    See related
    Ensembl:ENSG00000009694 MIM:300588; AllianceGenome:HGNC:8117
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TNM; ODZ1; ODZ3; TEN1; TNM1; ten-1; TEN-M1
    Summary
    The protein encoded by this gene belongs to the tenascin family and teneurin subfamily. It is expressed in the neurons and may function as a cellular signal transducer. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
    Expression
    Broad expression in prostate (RPKM 2.1), brain (RPKM 2.0) and 17 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TENM1 in Genome Data Viewer
    Location:
    Xq25
    Exon count:
    41
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (124375903..125204312, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (122686274..123514783, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (123509753..124338161, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373331 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chrX:123539864-123541063 Neighboring gene TEX13 family member D Neighboring gene SH2 domain containing 1A Neighboring gene NANOG hESC enhancer GRCh37_chrX:123622217-123622915 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chrX:123667881-123668476 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chrX:123668477-123669070 Neighboring gene ribosomal protein S26 pseudogene 57 Neighboring gene small nucleolar RNA U13 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:124139686-124140186 Neighboring gene MPRA-validated peak7424 silencer Neighboring gene uncharacterized LOC124905211 Neighboring gene TEX13 family member C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Glioblastoma invasion factor ODZ1 is induced by microenvironmental signals through activation of a Stat3-dependent transcriptional pathway. Vidal V, et al. Sci Rep, 2021 Aug 10. PMID 34376733, Free PMC Article
    2. Overexpression of teneurin transmembrane protein 1 is a potential marker of disease progression in papillary thyroid carcinoma. Cheng SP, et al. Clin Exp Med, 2017 Nov. PMID 28004221
    3. ODZ1 allows glioblastoma to sustain invasiveness through a Myc-dependent transcriptional upregulation of RhoA. Talamillo A, et al. Oncogene, 2017 Mar 23. PMID 27641332
    4. The teneurins: new players in the generation of visual topography. Leamey CA, et al. Semin Cell Dev Biol, 2014 Nov. PMID 25152333
    5. Epstein-Barr virus-negative boys with non-Hodgkin lymphoma are mutated in the SH2D1A gene, as are patients with X-linked lymphoproliferative disease (XLP). Brandau O, et al. Hum Mol Genet, 1999 Dec. PMID 10556288

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A Potential Four-Gene Signature and Nomogram for Predicting the Overall Survival of Papillary Thyroid Cancer.
      Title: A Potential Four-Gene Signature and Nomogram for Predicting the Overall Survival of Papillary Thyroid Cancer.
    2. HIF2alpha Upregulates the Migration Factor ODZ1 under Hypoxia in Glioblastoma Stem Cells.
      Title: HIF2α Upregulates the Migration Factor ODZ1 under Hypoxia in Glioblastoma Stem Cells.
    3. Identification and functional modelling of plausibly causative cis-regulatory variants in a highly-selected cohort with X-linked intellectual disability.
      Title: Identification and functional modelling of plausibly causative cis-regulatory variants in a highly-selected cohort with X-linked intellectual disability.
    4. Glioblastoma invasion factor ODZ1 is induced by microenvironmental signals through activation of a Stat3-dependent transcriptional pathway.
      Title: Glioblastoma invasion factor ODZ1 is induced by microenvironmental signals through activation of a Stat3-dependent transcriptional pathway.
    5. MicroRNA-486 inhibits cell proliferation, invasion and migration via down-regulating the TENM1 expressions and affecting ERK and Akt signaling pathways and epithelial-to-mesenchymal transition in papillary thyroid carcinoma.
      Title: MicroRNA-486 inhibits cell proliferation, invasion and migration via down-regulating the TENM1 expressions and affecting ERK and Akt signaling pathways and epithelial-to-mesenchymal transition in papillary thyroid carcinoma.
    6. Taken together, the results indicate that distinct pathways are involved in papillary thyroid cancer progression, and TENM1 is a potential marker of cancer progression.
      Title: Overexpression of teneurin transmembrane protein 1 is a potential marker of disease progression in papillary thyroid carcinoma.
    7. ODZ1, a protein that participates in the embryonic development of the brain, is also involved in cancer progression by promoting the growth and invasion capabilities of GSCs via a transcriptional pathway that induces the expression of RhoA and activation of downstream ROCK.
      Title: ODZ1 allows glioblastoma to sustain invasiveness through a Myc-dependent transcriptional upregulation of RhoA.
    8. Results of our study, that describes a new Tenm1 mouse, agree with the hypothesis that TENM1 has a role in olfaction. However, additional studies should be done in larger Congenital general anosmia (CGA) cohorts, to provide statistical evidence that loss-of-function mutations in TENM1 can solely cause the disease in our and other CGA cases
      Title: A role for TENM1 mutations in congenital general anosmia.
    9. Data suggest teneurin-1/TENM1 (and possibly TENM3) undergoes proteolysis to TCAPs (teneurin C-terminal associated peptides) that form intercellular adhesive units with latrophilin; signaling via TENM1 TCAPs appears to regulate reproduction. [REVIEW]
      Title: Role of the teneurins, teneurin C-terminal associated peptides (TCAP) in reproduction: clinical perspectives.
    10. This study identified predicted pathogenic, hemizygous variants on chromosome X in disease genes TENM1.
      Title: Whole-exome sequencing points to considerable genetic heterogeneity of cerebral palsy.
    Submit: New GeneRIF Correction See all GeneRIFs (15)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.
    EBI GWAS Catalog
    Genome-wide association study of d-amphetamine response in healthy volunteers identifies putative associations, including cadherin 13 (CDH13).
    EBI GWAS Catalog
    Genome-wide meta-analysis of systolic blood pressure in children with sickle cell disease.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat downregulates the expression of teneurin transmembrane protein 1 (TENM1; ODZ1) in human primary T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cell adhesion molecule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables heparin binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein heterodimerization activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein heterodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein homodimerization activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in immune response TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of cell population proliferation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in nervous system development TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in neuron development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuropeptide signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of MAP kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of actin filament polymerization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of filopodium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of intracellular protein transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of peptidyl-serine phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of transcription by RNA polymerase III ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoskeleton ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nuclear speck ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in perinuclear region of cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    teneurin-1
    Names
    odz (odd Oz/ten-m, Drosophila) homolog 3
    odz, odd Oz/ten-m homolog 1(Drosophila)
    protein Odd Oz/ten-m homolog 1
    tenascin M1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_013249.2 RefSeqGene

      Range
      245495..833409
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001163278.2 → NP_001156750.1  teneurin-1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001156750.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AL008707, AL022718, AL023878, AL031075, Z81008, Z83823, Z85995
      UniProtKB/TrEMBL
      A0A8Z5AZJ6
      Related
      ENSP00000403954.4, ENST00000422452.4
      Conserved Domains (10) summary
      COG3209
      Location:1825 → 2394
      RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:1197 → 1236
      NHL; NHL repeat [structural motif]
      TIGR01643
      Location:1852 → 1892
      YD_repeat_2x; YD repeat (two copies)
      TIGR03696
      Location:2346 → 2424
      Rhs_assc_core; RHS repeat-associated core domain
      pfam01500
      Location:529 → 732
      Keratin_B2; Keratin, high sulfur B2 protein
      pfam05593
      Location:1644 → 1678
      RHS_repeat; RHS Repeat
      pfam06484
      Location:23 → 317
      Ten_N; Teneurin Intracellular Region
      pfam07974
      Location:532 → 558
      EGF_2; EGF-like domain
      pfam15636
      Location:2650 → 2725
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      cl18310
      Location:1168 → 1528
      NHL; NHL repeat unit of beta-propeller proteins

    2. NM_001163279.1 → NP_001156751.1  teneurin-1 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001156751.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame acceptor splice site at one of the coding exons compared to variant 1. This results in an isoform (2) that is 1 aa shorter than isoform 1.
      Source sequence(s)
      AF100772, AI498402, AK055765, AL022718, BC030766, BC144543, BX478232, CF454574
      UniProtKB/TrEMBL
      A0A8Z5AZJ6, B7ZMH4
      Conserved Domains (10) summary
      COG3209
      Location:1824 → 2393
      RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:1196 → 1235
      NHL; NHL repeat [structural motif]
      TIGR01643
      Location:1851 → 1891
      YD_repeat_2x; YD repeat (two copies)
      TIGR03696
      Location:2345 → 2423
      Rhs_assc_core; RHS repeat-associated core domain
      pfam01500
      Location:528 → 731
      Keratin_B2; Keratin, high sulfur B2 protein
      pfam05593
      Location:1643 → 1677
      RHS_repeat; RHS Repeat
      pfam06484
      Location:23 → 317
      Ten_N; Teneurin Intracellular Region
      pfam07974
      Location:531 → 557
      EGF_2; EGF-like domain
      pfam15636
      Location:2649 → 2724
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      cl18310
      Location:1167 → 1527
      NHL; NHL repeat unit of beta-propeller proteins

    3. NM_014253.3 → NP_055068.2  teneurin-1 isoform 3 precursor

      See identical proteins and their annotated locations for NP_055068.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an in-frame coding exon compared to variant 1. This results in a shorter isoform (3) missing an internal 7 aa protein segment compared to isoform 1.
      Source sequence(s)
      AF100772, AI498402, AK055765, AL022718, BC030766, BC140783, BX478232, CF454574
      Consensus CDS
      CCDS14609.1
      UniProtKB/Swiss-Prot
      B2RTR5, Q5JZ17, Q9UKZ4
      UniProtKB/TrEMBL
      A0A8Z5AZJ6
      Related
      ENSP00000360171.3, ENST00000371130.7
      Conserved Domains (10) summary
      COG3209
      Location:1818 → 2387
      RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:1241 → 1284
      NHL; NHL repeat [structural motif]
      TIGR01643
      Location:1845 → 1885
      YD_repeat_2x; YD repeat (two copies)
      TIGR03696
      Location:2339 → 2417
      Rhs_assc_core; RHS repeat-associated core domain
      pfam01500
      Location:529 → 732
      Keratin_B2; Keratin, high sulfur B2 protein
      pfam05593
      Location:1637 → 1671
      RHS_repeat; RHS Repeat
      pfam06484
      Location:23 → 317
      Ten_N; Teneurin Intracellular Region
      pfam07974
      Location:532 → 558
      EGF_2; EGF-like domain
      pfam15636
      Location:2643 → 2718
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      cl18310
      Location:1168 → 1521
      NHL; NHL repeat unit of beta-propeller proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      124375903..125204312 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017029210.3 → XP_016884699.1  teneurin-1 isoform X1

      UniProtKB/TrEMBL
      A0A8Z5AZJ6

    2. XM_017029211.3 → XP_016884700.1  teneurin-1 isoform X1

      UniProtKB/TrEMBL
      A0A8Z5AZJ6

    3. XM_047441760.1 → XP_047297716.1  teneurin-1 isoform X3

    4. XM_017029214.3 → XP_016884703.1  teneurin-1 isoform X2

      UniProtKB/Swiss-Prot
      B2RTR5, Q5JZ17, Q9UKZ4
      UniProtKB/TrEMBL
      A0A8Z5AZJ6
      Conserved Domains (10) summary
      COG3209
      Location:1818 → 2387
      RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:1241 → 1284
      NHL; NHL repeat [structural motif]
      TIGR01643
      Location:1845 → 1885
      YD_repeat_2x; YD repeat (two copies)
      TIGR03696
      Location:2339 → 2417
      Rhs_assc_core; RHS repeat-associated core domain
      pfam01500
      Location:529 → 732
      Keratin_B2; Keratin, high sulfur B2 protein
      pfam05593
      Location:1637 → 1671
      RHS_repeat; RHS Repeat
      pfam06484
      Location:23 → 317
      Ten_N; Teneurin Intracellular Region
      pfam07974
      Location:532 → 558
      EGF_2; EGF-like domain
      pfam15636
      Location:2643 → 2718
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      cl18310
      Location:1168 → 1521
      NHL; NHL repeat unit of beta-propeller proteins

    5. XM_017029208.3 → XP_016884697.1  teneurin-1 isoform X1

      UniProtKB/TrEMBL
      A0A8Z5AZJ6

    6. XM_017029209.3 → XP_016884698.1  teneurin-1 isoform X1

      UniProtKB/TrEMBL
      A0A8Z5AZJ6

    7. XM_047441759.1 → XP_047297715.1  teneurin-1 isoform X1

    8. XM_017029213.3 → XP_016884702.1  teneurin-1 isoform X1

      UniProtKB/TrEMBL
      A0A8Z5AZJ6

    9. XM_011531236.4 → XP_011529538.2  teneurin-1 isoform X4

    10. XM_047441762.1 → XP_047297718.1  teneurin-1 isoform X6

    11. XM_047441761.1 → XP_047297717.1  teneurin-1 isoform X5

    12. XM_011531237.3 → XP_011529539.1  teneurin-1 isoform X7

      Conserved Domains (7) summary
      COG3209
      Location:493 → 1062
      RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:39 → 78
      NHL; NHL repeat [structural motif]
      TIGR01643
      Location:520 → 560
      YD_repeat_2x; YD repeat (two copies)
      TIGR03696
      Location:1014 → 1092
      Rhs_assc_core; RHS repeat-associated core domain
      pfam05593
      Location:312 → 346
      RHS_repeat; RHS Repeat
      pfam15636
      Location:1318 → 1393
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      cl18310
      Location:2 → 196
      NHL; NHL repeat unit of beta-propeller proteins

    13. XM_017029216.3 → XP_016884705.1  teneurin-1 isoform X9

    14. XM_017029215.3 → XP_016884704.1  teneurin-1 isoform X8

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      122686274..123514783 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054326349.1 → XP_054182324.1  teneurin-1 isoform X1

    2. XM_054326345.1 → XP_054182320.1  teneurin-1 isoform X1

    3. XM_054326346.1 → XP_054182321.1  teneurin-1 isoform X1

    4. XM_054326351.1 → XP_054182326.1  teneurin-1 isoform X3

    5. XM_054326350.1 → XP_054182325.1  teneurin-1 isoform X2

      UniProtKB/Swiss-Prot
      B2RTR5, Q5JZ17, Q9UKZ4

    6. XM_054326344.1 → XP_054182319.1  teneurin-1 isoform X1

    7. XM_054326347.1 → XP_054182322.1  teneurin-1 isoform X1

    8. XM_054326348.1 → XP_054182323.1  teneurin-1 isoform X1

    9. XM_054326352.1 → XP_054182327.1  teneurin-1 isoform X4

    10. XM_054326354.1 → XP_054182329.1  teneurin-1 isoform X6

    11. XM_054326353.1 → XP_054182328.1  teneurin-1 isoform X5

    12. XM_054326355.1 → XP_054182330.1  teneurin-1 isoform X7

    13. XM_054326357.1 → XP_054182332.1  teneurin-1 isoform X9

    14. XM_054326356.1 → XP_054182331.1  teneurin-1 isoform X8

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9UKZ4.2 GenPept UniProtKB/Swiss-Prot:Q9UKZ4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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