Conserved Protein Domain Family
Tox-GHH
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pfam15636: Tox-GHH (this model, PSSM-Id:292269 is obsolete and has been replaced by 464783)
GHH signature containing HNH/Endo VII superfamily nuclease toxin
A predicted toxin of the HNH/Endonuclease VII fold present in bacterial polymorphic toxin systems with a characteristic sG[HQ]H signature motif. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 6, type 7 or TcdB/TcaC-type secretion system. The metazoan teneurin proteins possess an inactive of this domain at their C-terminus.
Links
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Statistics
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PSSM-Id: 292269
Aligned: 39 rows
Threshold Bit Score: 83.4216
Created: 27-Jun-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
G5EGQ6       2609 VKKIVEELKTRENIAVWRAERKRAEAGEKTWRQWSDRETRELTSKGSVSGYD-----IEMK------PAHQ-SGLLASVH 2676 Caenorhabditi...
XP_011672532 2686 AEVVLESAREVAMHQAWLNERRVLASGLRGTYFWTSEERISLLQNNMVPGYE-----GQYTl-----DPMLyPEIAFDGN 2755 purple sea ur...
EFX87686     2182 tELLWRHSVKLAARRAWHREQILARRGGINTFLMTQSEMEQLSRDGHLPNYR-----PELQq-----SLWNyPLLADDPT 2251 common water ...
XP_004225782 2545 KEQVLREAQRRAENEAWEFERQKIQSGIRTR--WTEAEKQEIRSRHRLSSYQ-----LRPTw-----DPERyPELADSGR 2612 vase tunicate
XP_002598171 2476 QKRILDKAKVRGEQLVWTQELALVEQGLPTR--WDSEQQGDMRTYGHVPTYG-----ALYIr-----PSLQyPEMADDPR 2543 Florida lancelet
XP_003136624 2355 RSELIRQQTAEIGKIIWEDEAERARSGAITRHSWTESELSQLSSDGFVSGYE-----LNFh------PGNSmPILANT-Y 2422 eye worm
WP_015892702   73 WNRRLAKRRDAGVKEFWKQEKRRIKNGEPTTRNWTQEQKDAILSN-QVPTFN-----GKPItghhaySVSKyPHLANRGE 146  Brevibacillus...
XP_001900593 2353 RSELIREQTLEIGKIIWNDEVERARYGTITRHSWTESELSQLHSKGLVSGYE-----PKFr------PGKSvPVLWNT-Y 2420 Brugia malayi
WP_002895342  596 WNKRFTQRRNEGVESFWRDERVRLSRGEKGTRNWSEDQIKDILS-GKRAKFDgktlqGHHTy-----SASQyPHLANRSE 669  Streptococcus...
XP_009299669 2302 RTRVLDAARIRAVQGAWLREQKRVLEGDGGSLAWTDKEKDELIAEGHVSGYD-----GFYAl-----PVEQhPELADSPF 2371 zebrafish

G5EGQ6       2677 SWKFRK 2682 Caenorhabditis elegans
XP_011672532 2756 NIKIVR 2761 purple sea urchin
EFX87686     2252 AMRFRK 2257 common water flea
XP_004225782 2613 NMRFVK 2618 vase tunicate
XP_002598171 2544 NIKLVp 2549 Florida lancelet
XP_003136624 2423 LWIFQR 2428 eye worm
WP_015892702  147 IIYPVT 152  Brevibacillus brevis
XP_001900593 2421 LWTFQR 2426 Brugia malayi
WP_002895342  670 VIYPVT 675  Streptococcus sanguinis
XP_009299669 2372 NIHLir 2377 zebrafish
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