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Ttc17 tetratricopeptide repeat domain 17 [ Mus musculus (house mouse) ]

Gene ID: 74569, updated on 5-Mar-2024

Summary

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Official Symbol
Ttc17provided by MGI
Official Full Name
tetratricopeptide repeat domain 17provided by MGI
Primary source
MGI:MGI:1921819
See related
Ensembl:ENSMUSG00000027194 AllianceGenome:MGI:1921819
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D2Bwg1005e; 9130020K17Rik
Summary
Predicted to be involved in actin filament polymerization and cilium organization. Predicted to act upstream of or within cell projection organization. Predicted to be located in cytosol and plasma membrane. Predicted to be active in actin cytoskeleton and cytoplasm. Orthologous to human TTC17 (tetratricopeptide repeat domain 17). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 6.7), colon adult (RPKM 4.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 E1; 2 51.69 cM
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (94131111..94237034, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (94300766..94406710, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene MIR670 host gene (non-protein coding) Neighboring gene microRNA 129-2 Neighboring gene microRNA 129b Neighboring gene microRNA 670 Neighboring gene STARR-seq mESC enhancer starr_05177 Neighboring gene inosine triphosphatase (nucleoside triphosphate pyrophosphatase) pseudogene 1 Neighboring gene RIKEN cDNA 2810002D19 gene Neighboring gene STARR-positive B cell enhancer mm9_chr2:94278212-94278513 Neighboring gene apoptosis inhibitor 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Brady KP, et al. Genome Res, 1997 Nov. PMID 9371744, Free PMC Article
  2. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article
  3. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
  4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
  5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in actin filament polymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin filament polymerization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cell projection organization IEA
Inferred from Electronic Annotation
more info
  
involved_in cilium organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cilium organization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
tetratricopeptide repeat protein 17
Names
TPR repeat protein 17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355690.1 → NP_001342619.1  tetratricopeptide repeat protein 17 isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AL672251, AL683878
    Consensus CDS
    CCDS89523.1
    Related
    ENSMUSP00000106868.3, ENSMUST00000111237.9
    Conserved Domains (5) summary
    COG0457
    Location:979 → 1136
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:621 → 647
    TPR; TPR repeat [structural motif]
    cd16269
    Location:379 → 390
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:329 → 410
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl26002
    Location:573 → 718
    TPR_11; TPR repeat

  2. NM_001355691.1 → NP_001342620.1  tetratricopeptide repeat protein 17 isoform 3 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus and lacks an alternate internal segment compared to isoform 1.
    Source sequence(s)
    AL672251, AL683878
    Conserved Domains (4) summary
    sd00006
    Location:621 → 647
    TPR; TPR repeat [structural motif]
    cd16269
    Location:379 → 390
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:329 → 410
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl26002
    Location:573 → 718
    TPR_11; TPR repeat

  3. NM_183106.2 → NP_898929.2  tetratricopeptide repeat protein 17 isoform 1 precursor

    See identical proteins and their annotated locations for NP_898929.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AI851013, AK018641, AK038364, AL683878, BE626951, BY358550, CA328748, CF536785, CJ180754
    Consensus CDS
    CCDS38185.1
    UniProtKB/Swiss-Prot
    E9PVB5, Q4VBE5, Q5RKR1
    Related
    ENSMUSP00000106869.2, ENSMUST00000111238.8
    Conserved Domains (6) summary
    smart00028
    Location:689 → 718
    TPR; Tetratricopeptide repeats
    sd00006
    Location:621 → 647
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:1145 → 1175
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:1111 → 1173
    TPR_11; TPR repeat
    cd16269
    Location:379 → 390
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:329 → 410
    GBP_C; Guanylate-binding protein, C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    94131111..94237034 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006500310.5 → XP_006500373.1  tetratricopeptide repeat protein 17 isoform X1

    Conserved Domains (5) summary
    COG0457
    Location:995 → 1152
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    TIGR02917
    Location:532 → 677
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:580 → 606
    TPR; TPR repeat [structural motif]
    cd16269
    Location:338 → 349
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:288 → 369
    GBP_C; Guanylate-binding protein, C-terminal domain

  2. XM_006500312.5 → XP_006500375.1  tetratricopeptide repeat protein 17 isoform X2

    UniProtKB/TrEMBL
    A2AFY7
    Related
    ENSMUSP00000092395.5, ENSMUST00000094801.5
    Conserved Domains (5) summary
    TIGR02917
    Location:573 → 718
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:621 → 647
    TPR; TPR repeat [structural motif]
    cd16269
    Location:379 → 390
    GBP_C; coiled coil [structural motif]
    pfam00515
    Location:297 → 328
    TPR_1; Tetratricopeptide repeat
    cl20817
    Location:329 → 410
    GBP_C; Guanylate-binding protein, C-terminal domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E9PVB5.1 GenPept UniProtKB/Swiss-Prot:E9PVB5

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