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Conserved domains on  [gi|1245897721|ref|NP_001342619|]
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tetratricopeptide repeat protein 17 isoform 2 precursor [Mus musculus]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 11419012)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

Gene Ontology:  GO:0005515
PubMed:  10517866|30708253

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
1006-1132 2.12e-11

Tetratricopeptide (TPR) repeat [General function prediction only];


:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 65.41  E-value: 2.12e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1245897721 1006 KVLEKN-QTSWVLSSMAALYWRvKGQGKKAIDCLRQALHYAPHQmkDVPLISLANILHNAKLWNDAVIVATMAVEIAPHF 1084
Cdd:COG0457     33 KALELDpDDAEALYNLGLAYLR-LGRYEEALADYEQALELDPDD--AEALNNLGLALQALGRYEEALEDYDKALELDPDD 109

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1245897721 1085 AVNHFTLGNVYVAMEEFEKALVWYESTLKLQPEFVPAKNRIQTIQCHL 1132
Cdd:COG0457    110 AEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKL 157
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
610-724 1.20e-10

Tetratricopeptide (TPR) repeat [General function prediction only];


:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 63.10  E-value: 1.20e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1245897721  610 AINKPNAPVWLILneaGLYWRAVGNSTFAIACLQRALNLAPVQYQdiPLVNLANLLIHYGLHLDATKLLLQAVAVNSSEP 689
Cdd:COG0457     36 ELDPDDAEALYNL---GLAYLRLGRYEEALADYEQALELDPDDAE--ALNNLGLALQALGRYEEALEDYDKALELDPDDA 110

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1245897721  690 LTFLSLGNAYLALKNVSGALEAFRQALKLSTKCPE 724
Cdd:COG0457    111 EALYNLGLALLELGRYDEAIEAYERALELDPDDAD 145
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
226-406 5.62e-07

Tetratricopeptide (TPR) repeat [General function prediction only];


:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 51.93  E-value: 5.62e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1245897721  226 WVLYNLASFYWRIKNEPyQVVECAMRALHFSSRHnkDIALVNLANVLHRAHFSADAAVVVHAALD-DSDFFTSYYTLGNI 304
Cdd:COG0457     43 EALYNLGLAYLRLGRYE-EALADYEQALELDPDD--AEALNNLGLALQALGRYEEALEDYDKALElDPDDAEALYNLGLA 119

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1245897721  305 YAMLGEYNHSVLCYDHALQAKPGFEQAIKRKHAVLCQQKLEQKLEAQHRSLQRTLNELKEYQKQHDHYLRQQEILEKHKL 384
Cdd:COG0457    120 LLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLAL 199

                          170       180
                   ....*....|....*....|..
gi 1245897721  385 IQEEQILRNIIHETQMAKEAQL 406
Cdd:COG0457    200 LLALEQALRKKLAILTLAALAE 221
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
1006-1132 2.12e-11

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 65.41  E-value: 2.12e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1245897721 1006 KVLEKN-QTSWVLSSMAALYWRvKGQGKKAIDCLRQALHYAPHQmkDVPLISLANILHNAKLWNDAVIVATMAVEIAPHF 1084
Cdd:COG0457     33 KALELDpDDAEALYNLGLAYLR-LGRYEEALADYEQALELDPDD--AEALNNLGLALQALGRYEEALEDYDKALELDPDD 109

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1245897721 1085 AVNHFTLGNVYVAMEEFEKALVWYESTLKLQPEFVPAKNRIQTIQCHL 1132
Cdd:COG0457    110 AEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKL 157
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
610-724 1.20e-10

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 63.10  E-value: 1.20e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1245897721  610 AINKPNAPVWLILneaGLYWRAVGNSTFAIACLQRALNLAPVQYQdiPLVNLANLLIHYGLHLDATKLLLQAVAVNSSEP 689
Cdd:COG0457     36 ELDPDDAEALYNL---GLAYLRLGRYEEALADYEQALELDPDDAE--ALNNLGLALQALGRYEEALEDYDKALELDPDDA 110

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1245897721  690 LTFLSLGNAYLALKNVSGALEAFRQALKLSTKCPE 724
Cdd:COG0457    111 EALYNLGLALLELGRYDEAIEAYERALELDPDDAD 145
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
226-406 5.62e-07

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 51.93  E-value: 5.62e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1245897721  226 WVLYNLASFYWRIKNEPyQVVECAMRALHFSSRHnkDIALVNLANVLHRAHFSADAAVVVHAALD-DSDFFTSYYTLGNI 304
Cdd:COG0457     43 EALYNLGLAYLRLGRYE-EALADYEQALELDPDD--AEALNNLGLALQALGRYEEALEDYDKALElDPDDAEALYNLGLA 119

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1245897721  305 YAMLGEYNHSVLCYDHALQAKPGFEQAIKRKHAVLCQQKLEQKLEAQHRSLQRTLNELKEYQKQHDHYLRQQEILEKHKL 384
Cdd:COG0457    120 LLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLAL 199

                          170       180
                   ....*....|....*....|..
gi 1245897721  385 IQEEQILRNIIHETQMAKEAQL 406
Cdd:COG0457    200 LLALEQALRKKLAILTLAALAE 221
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 573-718 4.28e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 47.77  E-value: 4.28e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1245897721  573 RMDLKAKIPDD--------------HARKIL-LSRIKNYTVPEEEIGSFLFHAINKPNAPVWLILNEAGlYWRAVGNSTF 637
Cdd:TIGR02917  507 RIDIQEGNPDDaiqrfekvltidpkNLRAILaLAGLYLRTGNEEEAVAWLEKAAELNPQEIEPALALAQ-YYLGKGQLKK 585

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1245897721  638 AIACLQRALNLAPVQYQDIPLvnLANLLIHYGLHLDATKLLLQAVAVNSSEPLTFLSLGNAYLALKNVSGALEAFRQALK 717
Cdd:TIGR02917  586 ALAILNEAADAAPDSPEAWLM--LGRAQLAAGDLNKAVSSFKKLLALQPDSALALLLLADAYAVMKNYAKAITSLKRALE 663


                   .
gi 1245897721  718 L 718
Cdd:TIGR02917  664 L 664
GBP_C cd16269
Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal ...
 329-410 5.21e-04

Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal domain. Guanylate-binding proteins (GBPs) are synthesized after activation of the cell by interferons. The biochemical properties of GBPs are clearly different from those of Ras-like and heterotrimeric GTP-binding proteins. They bind guanine nucleotides with low affinity (micromolar range), are stable in their absence, and have a high turnover GTPase. In addition to binding GDP/GTP, they have the unique ability to bind GMP with equal affinity and hydrolyze GTP not only to GDP, but also to GMP. This C-terminal domain has been shown to mediate inhibition of endothelial cell proliferation by inflammatory cytokines.


Pssm-ID: 293879 [Multi-domain]  Cd Length: 291  Bit Score: 43.33  E-value: 5.21e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1245897721  329 EQAIKRKHAVL--CQQKLEQKLEAQHRSLQRTLNELKE-YQKQHDHYLRQQEILEKHKLIQEEQILRNIIHETQMAKEAQ 405
Cdd:cd16269    207 AEAAEQERKLLeeQQRELEQKLEDQERSYEEHLRQLKEkMEEERENLLKEQERALESKLKEQEALLEEGFKEQAELLQEE 286


                   ....*
gi 1245897721  406 LGNHQ 410
Cdd:cd16269    287 IRSLK 291
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 982-1116 1.44e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 42.76  E-value: 1.44e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1245897721  982 EVLQNLGKDQYPQQSLEQIGTRIAKVLEKNQTSWV-LSSMAALYWRVKgQGKKAIDCLRQALHYAPHQmkDVPLISLANI 1060
Cdd:TIGR02917  602 EAWLMLGRAQLAAGDLNKAVSSFKKLLALQPDSALaLLLLADAYAVMK-NYAKAITSLKRALELKPDN--TEAQIGLAQL 678

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1245897721 1061 LHNAKLWNDAVIVATMAVEIAPHFAVNHFTLGNVYVAMEEFEKALVWYESTLKLQP 1116
Cdd:TIGR02917  679 LLAAKRTESAKKIAKSLQKQHPKAALGFELEGDLYLRQKDYPAAIQAYRKALKRAP 734
TPR_12 pfam13424
Tetratricopeptide repeat;
658-721 1.61e-03

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 38.52  E-value: 1.61e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1245897721  658 LVNLANLLIHYGLHLDATKLLLQAVAVNSSEP--------LTFLSLGNAYLALKNVSGALEAFRQALKLSTK 721
Cdd:pfam13424    6 LNNLAAVLRRLGRYDEALELLEKALEIARRLLgpdhpltaTTLLNLGRLYLELGRYEEALELLERALALAEK 77
TPR_1 pfam00515
Tetratricopeptide repeat;
1088-1118 3.19e-03

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 36.24  E-value: 3.19e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1245897721 1088 HFTLGNVYVAMEEFEKALVWYESTLKLQPEF 1118
Cdd:pfam00515    4 LYNLGNAYFKLGKYDEALEYYEKALELNPNN 34
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 1088-1118 3.49e-03

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 36.27  E-value: 3.49e-03
                            10        20        30
                    ....*....|....*....|....*....|.
gi 1245897721  1088 HFTLGNVYVAMEEFEKALVWYESTLKLQPEF 1118
Cdd:smart00028    4 LYNLGNAYLKLGDYDEALEYYEKALELDPNN 34
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 689-718 4.51e-03

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 35.89  E-value: 4.51e-03
                            10        20        30
                    ....*....|....*....|....*....|
gi 1245897721   689 PLTFLSLGNAYLALKNVSGALEAFRQALKL 718
Cdd:smart00028    1 AEALYNLGNAYLKLGDYDEALEYYEKALEL 30
TPR_1 pfam00515
Tetratricopeptide repeat;
297-328 8.63e-03

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 35.09  E-value: 8.63e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1245897721  297 SYYTLGNIYAMLGEYNHSVLCYDHALQAKPGF 328
Cdd:pfam00515    3 ALYNLGNAYFKLGKYDEALEYYEKALELNPNN 34
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
1006-1132 2.12e-11

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 65.41  E-value: 2.12e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1245897721 1006 KVLEKN-QTSWVLSSMAALYWRvKGQGKKAIDCLRQALHYAPHQmkDVPLISLANILHNAKLWNDAVIVATMAVEIAPHF 1084
Cdd:COG0457     33 KALELDpDDAEALYNLGLAYLR-LGRYEEALADYEQALELDPDD--AEALNNLGLALQALGRYEEALEDYDKALELDPDD 109

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1245897721 1085 AVNHFTLGNVYVAMEEFEKALVWYESTLKLQPEFVPAKNRIQTIQCHL 1132
Cdd:COG0457    110 AEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKL 157
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
1015-1121 6.66e-11

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 63.87  E-value: 6.66e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1245897721 1015 WVLSSMAALYWRvKGQGKKAIDCLRQALHYAPHQmkDVPLISLANILHNAKLWNDAVIVATMAVEIAPHFAVNHFTLGNV 1094
Cdd:COG0457      9 EAYNNLGLAYRR-LGRYEEAIEDYEKALELDPDD--AEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLA 85

                           90       100
                   ....*....|....*....|....*..
gi 1245897721 1095 YVAMEEFEKALVWYESTLKLQPEFVPA 1121
Cdd:COG0457     86 LQALGRYEEALEDYDKALELDPDDAEA 112
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
610-724 1.20e-10

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 63.10  E-value: 1.20e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1245897721  610 AINKPNAPVWLILneaGLYWRAVGNSTFAIACLQRALNLAPVQYQdiPLVNLANLLIHYGLHLDATKLLLQAVAVNSSEP 689
Cdd:COG0457     36 ELDPDDAEALYNL---GLAYLRLGRYEEALADYEQALELDPDDAE--ALNNLGLALQALGRYEEALEDYDKALELDPDDA 110

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1245897721  690 LTFLSLGNAYLALKNVSGALEAFRQALKLSTKCPE 724
Cdd:COG0457    111 EALYNLGLALLELGRYDEAIEAYERALELDPDDAD 145
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
610-724 2.43e-10

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 62.33  E-value: 2.43e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1245897721  610 AINKPNAPVWLILneaGLYWRAVGNSTFAIACLQRALNLAPVQYQdiPLVNLANLLIHYGLHLDATKLLLQAVAVNSSEP 689
Cdd:COG0457      2 ELDPDDAEAYNNL---GLAYRRLGRYEEAIEDYEKALELDPDDAE--ALYNLGLAYLRLGRYEEALADYEQALELDPDDA 76

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1245897721  690 LTFLSLGNAYLALKNVSGALEAFRQALKLSTKCPE 724
Cdd:COG0457     77 EALNNLGLALQALGRYEEALEDYDKALELDPDDAE 111
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 610-729 4.68e-10

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 63.86  E-value: 4.68e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1245897721  610 AINKPNAPVWLILNEAglyWRAVGNSTFAIACLQRALNLAPVQYQdiPLVNLANLLIHYGLHLDATKLLLQAVAVNSSEP 689
Cdd:COG3914    106 ALNPDNAEALFNLGNL---LLALGRLEEALAALRRALALNPDFAE--AYLNLGEALRRLGRLEEAIAALRRALELDPDNA 180

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1245897721  690 LTFLSLGNAYLALKNVSGALEAFRQALKLSTKCPECESSL 729
Cdd:COG3914    181 EALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAHSNL 220
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 621-724 6.21e-10

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 63.47  E-value: 6.21e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1245897721  621 ILNEAGLYWRAVGNSTFAIACLQRALNLAPvQYQDIpLVNLANLLIHYGLHLDATKLLLQAVAVNSSEPLTFLSLGNAYL 700
Cdd:COG3914     80 LLELAALLLQALGRYEEALALYRRALALNP-DNAEA-LFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALR 157

                           90       100
                   ....*....|....*....|....
gi 1245897721  701 ALKNVSGALEAFRQALKLSTKCPE 724
Cdd:COG3914    158 RLGRLEEAIAALRRALELDPDNAE 181
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 615-719 6.37e-10

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 58.09  E-value: 6.37e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1245897721  615 NAPVWLILneaGLYWRAVGNSTFAIACLQRALNLAPvQYQDIpLVNLANLLIHYGLHLDATKLLLQAVAVNSSEPLTFLS 694
Cdd:COG4235     16 DAEGWLLL---GRAYLRLGRYDEALAAYEKALRLDP-DNADA-LLDLAEALLAAGDTEEAEELLERALALDPDNPEALYL 90

                           90       100
                   ....*....|....*....|....*
gi 1245897721  695 LGNAYLALKNVSGALEAFRQALKLS 719
Cdd:COG4235     91 LGLAAFQQGDYAEAIAAWQKLLALL 115
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 960-1121 1.50e-09

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 62.32  E-value: 1.50e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1245897721  960 LDHLHGVSNRASLHYTGESQLTEVLQNLGKDQYPQQSLEQIgtriakvLEKN-QTSWVLSSMAALYwRVKGQGKKAIDCL 1038
Cdd:COG3914     64 AGEAAAAAAALLLLAALLELAALLLQALGRYEEALALYRRA-------LALNpDNAEALFNLGNLL-LALGRLEEALAAL 135

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1245897721 1039 RQALHYAPHQMKdvPLISLANILHNAKLWNDAVIVATMAVEIAPHFAVNHFTLGNVYVAMEEFEKALVWYESTLKLQPEF 1118
Cdd:COG3914    136 RRALALNPDFAE--AYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDN 213


                   ...
gi 1245897721 1119 VPA 1121
Cdd:COG3914    214 ADA 216
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 1006-1121 1.58e-09

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 60.13  E-value: 1.58e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1245897721 1006 KVLEKN-QTSWVLSSMAALYWRvKGQGKKAIDCLRQALHYAPHQMKdvPLISLANILHNAKLWNDAVIVATMAVEIAPHF 1084
Cdd:COG2956     67 KLLERDpDRAEALLELAQDYLK-AGLLDRAEELLEKLLELDPDDAE--ALRLLAEIYEQEGDWEKAIEVLERLLKLGPEN 143

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1245897721 1085 AVNHFTLGNVYVAMEEFEKALVWYESTLKLQPEFVPA 1121
Cdd:COG2956    144 AHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARA 180
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 977-1128 3.51e-09

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 59.36  E-value: 3.51e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1245897721  977 ESQLTEVLQNLGKDQYPQQSLEQIGTRIAKVLEKNQTS-WVLSSMAALYwRVKGQGKKAIDCLRQALHYAPHQMkdVPLI 1055
Cdd:COG2956     72 DPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDaEALRLLAEIY-EQEGDWEKAIEVLERLLKLGPENA--HAYC 148

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1245897721 1056 SLANILHNAKLWNDAVIVATMAVEIAPHFAVNHFTLGNVYVAMEEFEKALVWYESTLKLQPEFVPAKNRIQTI 1128
Cdd:COG2956    149 ELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAEL 221
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 622-724 3.69e-09

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 56.35  E-value: 3.69e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1245897721  622 LNEAGLYWRAVGNSTFAIACLQRALNLAPVQYQdiPLVNLANLLIHYGLHLDATKLLLQAVAVNSSEPLTFLSLGNAYLA 701
Cdd:COG4783      7 LYALAQALLLAGDYDEAEALLEKALELDPDNPE--AFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLK 84

                           90       100
                   ....*....|....*....|...
gi 1245897721  702 LKNVSGALEAFRQALKLSTKCPE 724
Cdd:COG4783     85 AGDYDEALALLEKALKLDPEHPE 107
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 978-1118 8.71e-09

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 55.20  E-value: 8.71e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1245897721  978 SQLTEVLQNLGKDQYPQQSLEQIGTRIAKVLEKNQTS-WVLSSMAALYWRvKGQGKKAIDCLRQALHYAPHQmkDVPLIS 1056
Cdd:COG4783      1 AACAEALYALAQALLLAGDYDEAEALLEKALELDPDNpEAFALLGEILLQ-LGDLDEAIVLLHEALELDPDE--PEARLN 77

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1245897721 1057 LANILHNAKLWNDAVIVATMAVEIAPHFAVNHFTLGNVYVAMEEFEKALVWYESTLKLQPEF 1118
Cdd:COG4783     78 LGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELDPDD 139
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 1020-1125 1.09e-08

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 59.24  E-value: 1.09e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1245897721 1020 MAALYWRVKGQGKKAIDCLRQALHYAPHQMKdvPLISLANILHNAKLWNDAVIVATMAVEIAPHFAVNHFTLGNVYVAME 1099
Cdd:COG3914     83 LAALLLQALGRYEEALALYRRALALNPDNAE--ALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLG 160

                           90       100
                   ....*....|....*....|....*.
gi 1245897721 1100 EFEKALVWYESTLKLQPEFVPAKNRI 1125
Cdd:COG3914    161 RLEEAIAALRRALELDPDNAEALNNL 186
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 633-719 2.30e-08

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 54.58  E-value: 2.30e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1245897721  633 GNSTFAIACLQRALNLAPVQYQdiPLVNLANLLIHYGLHLDATKLLLQAVAVNSSEPLTFLSLGNAYLALKNVSGALEAF 712
Cdd:COG5010     68 GDFEESLALLEQALQLDPNNPE--LYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAAL 145


                   ....*..
gi 1245897721  713 RQALKLS 719
Cdd:COG5010    146 QRALGTS 152
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 1022-1128 2.47e-08

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 54.04  E-value: 2.47e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1245897721 1022 ALYWRVKGQGKKAIDCLRQALHYAPHQMkdVPLISLANILHNAKLWNDAVIVATMAVEIAPHFAVNHFTLGNVYVAMEEF 1101
Cdd:COG4783     11 AQALLLAGDYDEAEALLEKALELDPDNP--EAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDY 88

                           90       100
                   ....*....|....*....|....*..
gi 1245897721 1102 EKALVWYESTLKLQPEFVPAKNRIQTI 1128
Cdd:COG4783     89 DEALALLEKALKLDPEHPEAYLRLARA 115
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
619-733 8.26e-08

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 54.15  E-value: 8.26e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1245897721  619 WLILNEAGLYWRAVGNSTFAIACLQRALNLAPVQYQdiPLVNLANLLIHYGLHLDATKLLLQAVAVNSSEPLTFLSLGNA 698
Cdd:COG4785     73 AQLYYERGVAYDSLGDYDLAIADFDQALELDPDLAE--AYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYAYLNRGIA 150

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1245897721  699 YLALKNVSGALEAFRQALKLSTKCPECESSLKLIR 733
Cdd:COG4785    151 LYYLGRYELAIADLEKALELDPNDPERALWLYLAE 185
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
1028-1117 9.31e-08

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 50.94  E-value: 9.31e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1245897721 1028 KGQGKKAIDCLRQALHYAPHQMkdVPLISLANILHNAKLWNDAvIVATMAVEIAPHFAVNHFTLGNVYVAMEEFEKALVW 1107
Cdd:COG3063      5 LGDLEEAEEYYEKALELDPDNA--DALNNLGLLLLEQGRYDEA-IALEKALKLDPNNAEALLNLAELLLELGDYDEALAY 81

                           90
                   ....*....|
gi 1245897721 1108 YESTLKLQPE 1117
Cdd:COG3063     82 LERALELDPS 91
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 1010-1121 2.86e-07

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 50.77  E-value: 2.86e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1245897721 1010 KNQTSWVLssMAALYWRvKGQGKKAIDCLRQALHYAPhQMKDVpLISLANILHNAKLWNDAVIVATMAVEIAPHFAVNHF 1089
Cdd:COG4235     15 NDAEGWLL--LGRAYLR-LGRYDEALAAYEKALRLDP-DNADA-LLDLAEALLAAGDTEEAEELLERALALDPDNPEALY 89

                           90       100       110
                   ....*....|....*....|....*....|..
gi 1245897721 1090 TLGNVYVAMEEFEKALVWYESTLKLQPEFVPA 1121
Cdd:COG4235     90 LLGLAAFQQGDYAEAIAAWQKLLALLPADAPA 121
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
1054-1125 4.94e-07

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 52.32  E-value: 4.94e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1245897721 1054 LISLANILHNAKLWNDAVIVATMAVEIAPHFAVNHFTLGNVYVAMEEFEKALVWYESTLKLQPEFVPAKNRI 1125
Cdd:COG0457     11 YNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNL 82
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
226-406 5.62e-07

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 51.93  E-value: 5.62e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1245897721  226 WVLYNLASFYWRIKNEPyQVVECAMRALHFSSRHnkDIALVNLANVLHRAHFSADAAVVVHAALD-DSDFFTSYYTLGNI 304
Cdd:COG0457     43 EALYNLGLAYLRLGRYE-EALADYEQALELDPDD--AEALNNLGLALQALGRYEEALEDYDKALElDPDDAEALYNLGLA 119

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1245897721  305 YAMLGEYNHSVLCYDHALQAKPGFEQAIKRKHAVLCQQKLEQKLEAQHRSLQRTLNELKEYQKQHDHYLRQQEILEKHKL 384
Cdd:COG0457    120 LLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLAL 199

                          170       180
                   ....*....|....*....|..
gi 1245897721  385 IQEEQILRNIIHETQMAKEAQL 406
Cdd:COG0457    200 LLALEQALRKKLAILTLAALAE 221
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 1028-1116 7.47e-07

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 49.96  E-value: 7.47e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1245897721 1028 KGQGKKAIDCLRQALHYAPHQMKdvPLISLANILHNAKLWNDAVIVATMAVEIAPHFAVNHFTLGNVYVAMEEFEKALVW 1107
Cdd:COG5010     67 LGDFEESLALLEQALQLDPNNPE--LYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAA 144


                   ....*....
gi 1245897721 1108 YESTLKLQP 1116
Cdd:COG5010    145 LQRALGTSP 153
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
621-717 8.41e-07

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 51.55  E-value: 8.41e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1245897721  621 ILNEAGLYWRAVGNSTFAIACLQRALNLAPVQYQdiPLVNLANLLIHYGLHLDATKLLLQAVAVNSSEPLTFLSLGNAYL 700
Cdd:COG0457     78 ALNNLGLALQALGRYEEALEDYDKALELDPDDAE--ALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALE 155

                           90
                   ....*....|....*..
gi 1245897721  701 ALKNVSGALEAFRQALK 717
Cdd:COG0457    156 KLGRYEEALELLEKLEA 172
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 1006-1117 1.17e-06

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 51.65  E-value: 1.17e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1245897721 1006 KVLEKN-QTSWVLSSMAALYWRvKGQGKKAIDCLRQALHYAPHqmKDVPLISLANILHNAKLWNDAVIVATMAVEIAPHF 1084
Cdd:COG2956     33 EALELDpETVEAHLALGNLYRR-RGEYDRAIRIHQKLLERDPD--RAEALLELAQDYLKAGLLDRAEELLEKLLELDPDD 109

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1245897721 1085 AVNHFTLGNVYVAMEEFEKALVWYESTLKLQPE 1117
Cdd:COG2956    110 AEALRLLAEIYEQEGDWEKAIEVLERLLKLGPE 142
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
628-719 1.28e-06

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 47.86  E-value: 1.28e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1245897721  628 YWRAVGNSTFAIACLQRALNLAPVQYQdiPLVNLANLLIHYGLHLDATKLLlQAVAVNSSEPLTFLSLGNAYLALKNVSG 707
Cdd:COG3063      1 LYLKLGDLEEAEEYYEKALELDPDNAD--ALNNLGLLLLEQGRYDEAIALE-KALKLDPNNAEALLNLAELLLELGDYDE 77

                           90
                   ....*....|..
gi 1245897721  708 ALEAFRQALKLS 719
Cdd:COG3063     78 ALAYLERALELD 89
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
1006-1126 1.29e-06

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 51.16  E-value: 1.29e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1245897721 1006 KVLEKN-QTSWVLSSMAALYWRvKGQGKKAIDCLRQALHYAPHQMKdvPLISLANILHNAKLWNDAVIVATMAVEIAPHF 1084
Cdd:COG0457     67 QALELDpDDAEALNNLGLALQA-LGRYEEALEDYDKALELDPDDAE--ALYNLGLALLELGRYDEAIEAYERALELDPDD 143

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1245897721 1085 AVNHFTLGNVYVAMEEFEKALVWYESTLKLQPEFVPAKNRIQ 1126
Cdd:COG0457    144 ADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGE 185
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 1033-1121 1.69e-06

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 48.46  E-value: 1.69e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1245897721 1033 KAIDCLRQALHYAPHQMKDvpLISLANILHNAKLWNDAVIVATMAVEIAPHFAVNHFTLGNVYVAMEEFEKALVWYESTL 1112
Cdd:COG4235      1 EAIARLRQALAANPNDAEG--WLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERAL 78


                   ....*....
gi 1245897721 1113 KLQPEFVPA 1121
Cdd:COG4235     79 ALDPDNPEA 87
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 1020-1136 2.08e-06

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 50.88  E-value: 2.08e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1245897721 1020 MAALYWRVKGQGKKAIDCLRQALHYAPHQMKdvPLISLANILHNAKLWNDAVIVATMAVEIAPHFAVNHFTLGNVYVAME 1099
Cdd:COG2956     13 FKGLNYLLNGQPDKAIDLLEEALELDPETVE--AHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAG 90

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1245897721 1100 EFEKALVWYESTLKLQPEFVPAKNRIqtIQCHLMLKK 1136
Cdd:COG2956     91 LLDRAEELLEKLLELDPDDAEALRLL--AEIYEQEGD 125
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 638-719 4.72e-06

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 47.49  E-value: 4.72e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1245897721  638 AIACLQRALNLAPVQYQdiPLVNLANLLIHYGLHLDATKLLLQAVAVNSSEPLTFLSLGNAYLALKNVSGALEAFRQALK 717
Cdd:COG4783     57 AIVLLHEALELDPDEPE--ARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALE 134


                   ..
gi 1245897721  718 LS 719
Cdd:COG4783    135 LD 136
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 638-725 5.81e-06

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 49.34  E-value: 5.81e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1245897721  638 AIACLQRALNLAPVQYQdiPLVNLANLLIHYGLHLDATKLLLQAVAVNSSEPLTFLSLGNAYLALKNVSGALEAFRQALK 717
Cdd:COG2956     61 AIRIHQKLLERDPDRAE--ALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLK 138


                   ....*...
gi 1245897721  718 LSTKCPEC 725
Cdd:COG2956    139 LGPENAHA 146
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 638-718 1.72e-05

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 47.80  E-value: 1.72e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1245897721  638 AIACLQRALNLAPVQYQdiPLVNLANLLIHYGLHLDATKLLLQAVAVNSSEPLTFLSLGNAYLALKNVSGALEAFRQALK 717
Cdd:COG2956    129 AIEVLERLLKLGPENAH--AYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALE 206


                   .
gi 1245897721  718 L 718
Cdd:COG2956    207 Q 207
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 573-718 4.28e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 47.77  E-value: 4.28e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1245897721  573 RMDLKAKIPDD--------------HARKIL-LSRIKNYTVPEEEIGSFLFHAINKPNAPVWLILNEAGlYWRAVGNSTF 637
Cdd:TIGR02917  507 RIDIQEGNPDDaiqrfekvltidpkNLRAILaLAGLYLRTGNEEEAVAWLEKAAELNPQEIEPALALAQ-YYLGKGQLKK 585

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1245897721  638 AIACLQRALNLAPVQYQDIPLvnLANLLIHYGLHLDATKLLLQAVAVNSSEPLTFLSLGNAYLALKNVSGALEAFRQALK 717
Cdd:TIGR02917  586 ALAILNEAADAAPDSPEAWLM--LGRAQLAAGDLNKAVSSFKKLLALQPDSALALLLLADAYAVMKNYAKAITSLKRALE 663


                   .
gi 1245897721  718 L 718
Cdd:TIGR02917  664 L 664
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 610-724 5.05e-05

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 46.26  E-value: 5.05e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1245897721  610 AINKPNAPVWLILneAGLYWRAvGNSTFAIACLQRALNLAPVQYQdiPLVNLANLLIHYGLHLDATKLLLQAVAVNSSEP 689
Cdd:COG2956     70 ERDPDRAEALLEL--AQDYLKA-GLLDRAEELLEKLLELDPDDAE--ALRLLAEIYEQEGDWEKAIEVLERLLKLGPENA 144

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1245897721  690 LTFLSLGNAYLALKNVSGALEAFRQALKLSTKCPE 724
Cdd:COG2956    145 HAYCELAELYLEQGDYDEAIEALEKALKLDPDCAR 179
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
1054-1121 7.58e-05

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 45.29  E-value: 7.58e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1245897721 1054 LISLANILHNAKLWNDAVIVATMAVEIAPHFAVNHFTLGNVYVAMEEFEKALVWYESTLKLQPEFVPA 1121
Cdd:COG4785     76 YYERGVAYDSLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYA 143
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 622-718 1.07e-04

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 46.52  E-value: 1.07e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1245897721  622 LNEAGLYWRAVGNSTFAIACLQRALNLAPVQYQDiplvnlANLLIHYGLHLDATKLLLQAVAVNSSEPLTFLSLGNAYLA 701
Cdd:COG3914     51 LAEAAAAALLALAAGEAAAAAAALLLLAALLELA------ALLLQALGRYEEALALYRRALALNPDNAEALFNLGNLLLA 124

                           90
                   ....*....|....*..
gi 1245897721  702 LKNVSGALEAFRQALKL 718
Cdd:COG3914    125 LGRLEEALAALRRALAL 141
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 621-718 2.33e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 44.33  E-value: 2.33e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1245897721  621 ILNEAGLYWRAVGNSTFAIACLQRALNLAPvqyQDIP-LVNLANLLIHYGLHLDATKLLLQAVAVNSSEPLTFLSLGNAY 699
Cdd:COG2956    146 AYCELAELYLEQGDYDEAIEALEKALKLDP---DCARaLLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAELY 222

                           90
                   ....*....|....*....
gi 1245897721  700 LALKNVSGALEAFRQALKL 718
Cdd:COG2956    223 EKLGDPEEALELLRKALEL 241
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 638-729 4.11e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 43.56  E-value: 4.11e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1245897721  638 AIACLQRALNLAPvQYQDIpLVNLANLLIHYGLHLDATKLLLQAVAVNSSEPLTFLSLGNAYLALKNVSGALEAFRQALK 717
Cdd:COG2956     27 AIDLLEEALELDP-ETVEA-HLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLE 104

                           90
                   ....*....|..
gi 1245897721  718 LSTKCPECESSL 729
Cdd:COG2956    105 LDPDDAEALRLL 116
GBP_C cd16269
Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal ...
 329-410 5.21e-04

Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal domain. Guanylate-binding proteins (GBPs) are synthesized after activation of the cell by interferons. The biochemical properties of GBPs are clearly different from those of Ras-like and heterotrimeric GTP-binding proteins. They bind guanine nucleotides with low affinity (micromolar range), are stable in their absence, and have a high turnover GTPase. In addition to binding GDP/GTP, they have the unique ability to bind GMP with equal affinity and hydrolyze GTP not only to GDP, but also to GMP. This C-terminal domain has been shown to mediate inhibition of endothelial cell proliferation by inflammatory cytokines.


Pssm-ID: 293879 [Multi-domain]  Cd Length: 291  Bit Score: 43.33  E-value: 5.21e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1245897721  329 EQAIKRKHAVL--CQQKLEQKLEAQHRSLQRTLNELKE-YQKQHDHYLRQQEILEKHKLIQEEQILRNIIHETQMAKEAQ 405
Cdd:cd16269    207 AEAAEQERKLLeeQQRELEQKLEDQERSYEEHLRQLKEkMEEERENLLKEQERALESKLKEQEALLEEGFKEQAELLQEE 286


                   ....*
gi 1245897721  406 LGNHQ 410
Cdd:cd16269    287 IRSLK 291
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 615-736 9.46e-04

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 41.10  E-value: 9.46e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1245897721  615 NAPVWLILNEAGLYWRAVGNSTFAIACLQRALNLAPVQYQDIPLVNLANLLIHY--GLHLDATKLLLQAVAVNSSEPLTF 692
Cdd:COG5010     12 LYLLLLTKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNklGDFEESLALLEQALQLDPNNPELY 91

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 1245897721  693 LSLGNAYLALKNVSGALEAFRQALKLSTKCPECESSLKLIRCMQ 736
Cdd:COG5010     92 YNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSL 135
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 1059-1123 1.08e-03

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 41.10  E-value: 1.08e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1245897721 1059 NILHNAKLWNDAVIVATMAVEIAPHFAVNHFTLGNVYVAMEEFEKALVWYESTLKLQPEFVPAKN 1123
Cdd:COG5010     62 NLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYS 126
ClassIIa_HDAC5_Gln-rich-N cd10164
Glutamine-rich N-terminal helical domain of HDAC5, a Class IIa histone deacetylase; This ...
 338-424 1.12e-03

Glutamine-rich N-terminal helical domain of HDAC5, a Class IIa histone deacetylase; This family consists of the glutamine-rich domain of histone deacetylase 5 (HDAC5). It belongs to a superfamily that consists of the glutamine-rich N-terminal helical extension to certain Class IIa histone deacetylases (HDACs), including HDAC4, HDAC5 and HDCA9; it is missing from HDAC7. This domain confers responsiveness to calcium signals and mediates interactions with transcription factors and cofactors, and it is able to repress transcription independently of the HDAC C-terminal, zinc-dependent catalytic domain. It has many intra- and inter-helical interactions which are possibly involved in reversible assembly and disassembly of proteins. HDACs regulate diverse cellular processes through enzymatic deacetylation of histone as well as non-histone proteins, in particular deacetylating N(6)-acetyl-lysine residues.


Pssm-ID: 197400 [Multi-domain]  Cd Length: 97  Bit Score: 39.42  E-value: 1.12e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1245897721  338 VLCQQKLEQKLEA--QHRSLQRTLnELKEYQKQHDHYLRQQEI-LEKHKLIQEEQILRNIIHETQMAKEAQLGNHQICRL 414
Cdd:cd10164      3 SLREQQLQQELLLlkQQQQLQKQL-LFAEFQKQHEHLTRQHEVqLQKHLKVRAELFSEQQQQEILAAKRQQELEQQRKRE 81

                           90
                   ....*....|
gi 1245897721  415 VNQQHSLHCQ 424
Cdd:cd10164     82 QQRQEELEKQ 91
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 982-1116 1.44e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 42.76  E-value: 1.44e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1245897721  982 EVLQNLGKDQYPQQSLEQIGTRIAKVLEKNQTSWV-LSSMAALYWRVKgQGKKAIDCLRQALHYAPHQmkDVPLISLANI 1060
Cdd:TIGR02917  602 EAWLMLGRAQLAAGDLNKAVSSFKKLLALQPDSALaLLLLADAYAVMK-NYAKAITSLKRALELKPDN--TEAQIGLAQL 678

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1245897721 1061 LHNAKLWNDAVIVATMAVEIAPHFAVNHFTLGNVYVAMEEFEKALVWYESTLKLQP 1116
Cdd:TIGR02917  679 LLAAKRTESAKKIAKSLQKQHPKAALGFELEGDLYLRQKDYPAAIQAYRKALKRAP 734
TPR_12 pfam13424
Tetratricopeptide repeat;
658-721 1.61e-03

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 38.52  E-value: 1.61e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1245897721  658 LVNLANLLIHYGLHLDATKLLLQAVAVNSSEP--------LTFLSLGNAYLALKNVSGALEAFRQALKLSTK 721
Cdd:pfam13424    6 LNNLAAVLRRLGRYDEALELLEKALEIARRLLgpdhpltaTTLLNLGRLYLELGRYEEALELLERALALAEK 77
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 1054-1138 2.43e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 39.40  E-value: 2.43e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1245897721 1054 LISLANILHNAKLWNDAVIVATMAVEIAPHFAVNHFTLGNVYVAMEEFEKALVWYESTLKLQPEFVPAKNRIqtiqCHLM 1133
Cdd:COG4783      7 LYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNL----GLAL 82


                   ....*
gi 1245897721 1134 LKKGR 1138
Cdd:COG4783     83 LKAGD 87
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 1004-1122 2.67e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 41.99  E-value: 2.67e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1245897721 1004 IAKVLE---KNQTSWVLSsmaALYWRVKGQGKKAIDCLRQALHYAPHQMKdvPLISLANILHNAKLWNDAVIVATMAVEI 1080
Cdd:TIGR02917  182 IDEVLTadpGNVDALLLK---GDLLLSLGNIELALAAYRKAIALRPNNIA--VLLALATILIEAGEFEEAEKHADALLKK 256

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1245897721 1081 APHFAVNHFTLGNVYVAMEEFEKALVWYESTLKLQPEFVPAK 1122
Cdd:TIGR02917  257 APNSPLAHYLKALVDFQKKNYEDARETLQDALKSAPEYLPAL 298
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 172-385 2.80e-03

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 41.90  E-value: 2.80e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1245897721  172 AFQHLRGVQERVNLSAPLLPKEDPIFTYLSKRLGRSIDDIGHLIHeGLQKNASS-WVLYNLASFYwRIKNEPYQVVECAM 250
Cdd:COG3914     59 LLALAAGEAAAAAAALLLLAALLELAALLLQALGRYEEALALYRR-ALALNPDNaEALFNLGNLL-LALGRLEEALAALR 136

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1245897721  251 RALHFSSRHNKdiALVNLANVLHRAH-FSADAAVVVHAALDDSDFFTSYYTLGNIYAMLGEYNHSVLCYDHALQAKPGFE 329
Cdd:COG3914    137 RALALNPDFAE--AYLNLGEALRRLGrLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNA 214

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1245897721  330 QAIKRKHAVLCQQKLEQKLEAQHRSLQRTLNELKEYQKQHDHYLRQ---QEILEKHKLI 385
Cdd:COG3914    215 DAHSNLLFALRQACDWEVYDRFEELLAALARGPSELSPFALLYLPDddpAELLALARAW 273
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
1078-1125 2.83e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 40.76  E-value: 2.83e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1245897721 1078 VEIAPHFAVNHFTLGNVYVAMEEFEKALVWYESTLKLQPEFVPAKNRI 1125
Cdd:COG0457      1 LELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNL 48
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 673-719 2.91e-03

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 39.22  E-value: 2.91e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1245897721  673 DATKLLLQAVAVNSSEPLTFLSLGNAYLALKNVSGALEAFRQALKLS 719
Cdd:COG4235      1 EAIARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLD 47
TPR_1 pfam00515
Tetratricopeptide repeat;
1088-1118 3.19e-03

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 36.24  E-value: 3.19e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1245897721 1088 HFTLGNVYVAMEEFEKALVWYESTLKLQPEF 1118
Cdd:pfam00515    4 LYNLGNAYFKLGKYDEALEYYEKALELNPNN 34
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 1088-1118 3.49e-03

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 36.27  E-value: 3.49e-03
                            10        20        30
                    ....*....|....*....|....*....|.
gi 1245897721  1088 HFTLGNVYVAMEEFEKALVWYESTLKLQPEF 1118
Cdd:smart00028    4 LYNLGNAYLKLGDYDEALEYYEKALELDPNN 34
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
291-356 3.81e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 40.38  E-value: 3.81e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1245897721  291 DSDFFTSYYTLGNIYAMLGEYNHSVLCYDHALQAKPGFEQAIKRKHAVLCQQ-KLEQKLEAQHRSLQ 356
Cdd:COG0457      4 DPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLgRYEEALADYEQALE 70
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 689-718 4.51e-03

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 35.89  E-value: 4.51e-03
                            10        20        30
                    ....*....|....*....|....*....|
gi 1245897721   689 PLTFLSLGNAYLALKNVSGALEAFRQALKL 718
Cdd:smart00028    1 AEALYNLGNAYLKLGDYDEALEYYEKALEL 30
TPR_16 pfam13432
Tetratricopeptide repeat; This family is found predominantly at the C-terminus of ...
 673-719 7.00e-03

Tetratricopeptide repeat; This family is found predominantly at the C-terminus of transglutaminase enzyme core regions.


Pssm-ID: 433202 [Multi-domain]  Cd Length: 68  Bit Score: 36.16  E-value: 7.00e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1245897721  673 DATKLLLQAVAVNSSEPLTF---LSLGNAYLALKNVSGALEAFRQALKLS 719
Cdd:pfam13432   15 DAAAALEAALARFPESPDAAaalLLLGLAALRQGRLAEAAAAYRAALRAA 64
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
291-378 7.26e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 39.60  E-value: 7.26e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1245897721  291 DSDFFTSYYTLGNIYAMLGEYNHSVLCYDHALQAKPGFEQAIKRKHAVLCQQK--------LEQKLEAQ------HRSLQ 356
Cdd:COG0457     38 DPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQALGryeealedYDKALELDpddaeaLYNLG 117

                           90       100
                   ....*....|....*....|..
gi 1245897721  357 RTLNELKEYQKQHDHYLRQQEI 378
Cdd:COG0457    118 LALLELGRYDEAIEAYERALEL 139
TPR_1 pfam00515
Tetratricopeptide repeat;
297-328 8.63e-03

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 35.09  E-value: 8.63e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1245897721  297 SYYTLGNIYAMLGEYNHSVLCYDHALQAKPGF 328
Cdd:pfam00515    3 ALYNLGNAYFKLGKYDEALEYYEKALELNPNN 34
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
226-392 9.32e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 39.22  E-value: 9.32e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1245897721  226 WVLYNLASFYWRIkNEPYQVVECAMRALHFSSRHNKdiALVNLANVLHRAHFSADAAVVVHAALD-DSDFFTSYYTLGNI 304
Cdd:COG0457     77 EALNNLGLALQAL-GRYEEALEDYDKALELDPDDAE--ALYNLGLALLELGRYDEAIEAYERALElDPDDADALYNLGIA 153

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1245897721  305 YAMLGEYNHSVLCYDHALQAKPGFEQAIKRKHAVLCQQKLEQKLEAQHRSLQRTLNELKEYQKQHDHYLRQQEILEKHKL 384
Cdd:COG0457    154 LEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAALAELLLLALALLLAL 233


                   ....*...
gi 1245897721  385 IQEEQILR 392
Cdd:COG0457    234 RLAALALY 241
TPR_1 pfam00515
Tetratricopeptide repeat;
689-718 9.33e-03

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 34.70  E-value: 9.33e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1245897721  689 PLTFLSLGNAYLALKNVSGALEAFRQALKL 718
Cdd:pfam00515    1 AKALYNLGNAYFKLGKYDEALEYYEKALEL 30
TPR_2 pfam07719
Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats ...
 695-718 9.69e-03

Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats (TPR) that are not matched by pfam00515.


Pssm-ID: 429619 [Multi-domain]  Cd Length: 33  Bit Score: 34.81  E-value: 9.69e-03
                           10        20
                   ....*....|....*....|....
gi 1245897721  695 LGNAYLALKNVSGALEAFRQALKL 718
Cdd:pfam07719    7 LGLAYYKLGDYEEALEAYEKALEL 30
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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