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Phactr3 phosphatase and actin regulator 3 [ Mus musculus (house mouse) ]

Gene ID: 74189, updated on 30-Apr-2024

Summary

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Official Symbol
Phactr3provided by MGI
Official Full Name
phosphatase and actin regulator 3provided by MGI
Primary source
MGI:MGI:1921439
See related
Ensembl:ENSMUSG00000027525 AllianceGenome:MGI:1921439
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
H17739; Scapin1; Scapinin; mKIAA4224; 1500003N10Rik; 4930415A02Rik
Summary
Predicted to enable actin binding activity. Predicted to be involved in actin cytoskeleton organization. Predicted to be located in nucleoplasm. Is expressed in several structures, including brain; skeletal muscle; testis; and trunk. Orthologous to human PHACTR3 (phosphatase and actin regulator 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in frontal lobe adult (RPKM 15.2), cortex adult (RPKM 14.8) and 5 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 H4; 2 99.67 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (177760768..177980285)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (178118975..178338492)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr2:177757807-177758108 Neighboring gene zinc finger protein 971 Neighboring gene STARR-positive B cell enhancer mm9_chr2:177792959-177793260 Neighboring gene STARR-seq mESC enhancer starr_06699 Neighboring gene zinc finger protein 931 Neighboring gene synaptonemal complex protein 2 Neighboring gene GC-rich promoter binding protein 1 pseudogene Neighboring gene protein phosphatase 1, regulatory subunit 3D Neighboring gene family with sequence similarity 217, member B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Paramutation-like effects at the mouse scapinin (Phactr3) locus. Worch S, et al. J Mol Biol, 2008 Mar 28. PMID 18295233
  2. Neuron-enriched phosphatase and actin regulator 3 (Phactr3)/ nuclear scaffold-associated PP1-inhibiting protein (Scapinin) regulates dendritic morphology via its protein phosphatase 1-binding domain. Miyata T, et al. Biochem Biophys Res Commun, 2020 Jul 23. PMID 32423795
  3. Genomic organization and expression pattern of scapinin (PHACTR3) in mouse and human. Worch S, et al. Cytogenet Genome Res, 2006. PMID 16974080
  4. Different expression patterns of Phactr family members in normal and injured mouse brain. Kim JY, et al. Neuroscience, 2012 Sep 27. PMID 22766235
  5. Genome-wide analysis of H4K5 acetylation associated with fear memory in mice. Park CS, et al. BMC Genomics, 2013 Aug 8. PMID 23927422, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Neuron-enriched phosphatase and actin regulator 3 (Phactr3)/ nuclear scaffold-associated PP1-inhibiting protein (Scapinin) regulates dendritic morphology via its protein phosphatase 1-binding domain.
    Title: Neuron-enriched phosphatase and actin regulator 3 (Phactr3)/ nuclear scaffold-associated PP1-inhibiting protein (Scapinin) regulates dendritic morphology via its protein phosphatase 1-binding domain.
  2. This study demonistrated that Phactr1 appeared to be expressed in post-mitotic neurons in developmental brain.
    Title: Different expression patterns of Phactr family members in normal and injured mouse brain.
  3. Phactr3 exon 1C splice variant is potentially strain specific regulated, leading to the expression of only one allele of the reciprocal crosses.
    Title: Paramutation-like effects at the mouse scapinin (Phactr3) locus.
  4. Expression analysis in the mouse revealed a tissue-specific complex transcription pattern in the brain and a specific pattern was observed during prenatal development
    Title: Genomic organization and expression pattern of scapinin (PHACTR3) in mouse and human.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA4224

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin binding ISO
Inferred from Sequence Orthology
more info
  
enables protein phosphatase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
phosphatase and actin regulator 3
Names
scaffold-associated PP1-inhibiting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007154.3 → NP_001007155.1  phosphatase and actin regulator 3 isoform 2

    See identical proteins and their annotated locations for NP_001007155.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AK038449, AL772217, BY127674
    Consensus CDS
    CCDS17159.1
    UniProtKB/TrEMBL
    Q5DTG6, Q6KCA9
    Related
    ENSMUSP00000099354.2, ENSMUST00000103065.2
    Conserved Domains (2) summary
    smart00707
    Location:399 → 423
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
    pfam17380
    Location:353 → 506
    DUF5401; Family of unknown function (DUF5401)

  2. NM_001177789.1 → NP_001171260.1  phosphatase and actin regulator 3 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AK039213, AL731783, AL772217, BC058621
    Consensus CDS
    CCDS50837.1
    UniProtKB/TrEMBL
    Q5DTG6
    Related
    ENSMUSP00000104544.2, ENSMUST00000108916.8
    Conserved Domains (1) summary
    smart00707
    Location:435 → 459
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2

  3. NM_001177790.1 → NP_001171261.1  phosphatase and actin regulator 3 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. This variant (4) also uses an alternate in-frame splice site in the 3' coding region. The encoded isoform (4) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AK005136, AL731783, AL772217, BC058621
    Consensus CDS
    CCDS50838.1
    UniProtKB/TrEMBL
    A2AHM4, Q5DTG6
    Related
    ENSMUSP00000104545.2, ENSMUST00000108917.8
    Conserved Domains (1) summary
    smart00707
    Location:436 → 458
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2

  4. NM_001177791.1 → NP_001171262.1  phosphatase and actin regulator 3 isoform 5

    See identical proteins and their annotated locations for NP_001171262.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (5) has a distinct N-terminus and is longer than isoform 1.
    Source sequence(s)
    AK005136, AL731783, AL772217
    Consensus CDS
    CCDS50839.1
    UniProtKB/TrEMBL
    Q5DTG6
    Related
    ENSMUSP00000104543.2, ENSMUST00000108915.8
    Conserved Domains (1) summary
    smart00707
    Location:440 → 464
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2

  5. NM_028806.2 → NP_083082.1  phosphatase and actin regulator 3 isoform 1

    See identical proteins and their annotated locations for NP_083082.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
    Source sequence(s)
    AK135144, AL772217, BC058621
    Consensus CDS
    CCDS17158.1
    UniProtKB/Swiss-Prot
    Q8BYK5, Q8BYS8, Q8C058, Q9DB87
    UniProtKB/TrEMBL
    Q5DTG6
    Related
    ENSMUSP00000099355.4, ENSMUST00000103066.10
    Conserved Domains (2) summary
    smart00707
    Location:439 → 463
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
    pfam15345
    Location:33 → 87
    TMEM51; Transmembrane protein 51

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    177760768..177980285
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006500730.4 → XP_006500793.1  phosphatase and actin regulator 3 isoform X1

    See identical proteins and their annotated locations for XP_006500793.1

    UniProtKB/TrEMBL
    Q5DTG6, Q6KCA9
    Conserved Domains (2) summary
    smart00707
    Location:399 → 423
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
    pfam17380
    Location:353 → 506
    DUF5401; Family of unknown function (DUF5401)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BYK5.2 GenPept UniProtKB/Swiss-Prot:Q8BYK5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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