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Conserved domains on  [gi|295317318|ref|NP_001171261|]
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phosphatase and actin regulator 3 isoform 4 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RPEL super family cl29414
RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL ...
 436-458 1.09e-03

RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL motif binds to actin.


The actual alignment was detected with superfamily member smart00707:

Pssm-ID: 475195  Cd Length: 26  Bit Score: 36.30  E-value: 1.09e-03
                           10        20
                   ....*....|....*....|...
gi 295317318   436 LSKLSQRPAVEELERRNILKQRN 458
Cdd:smart00707   4 NRKLSQRPTREELEERNILKELS 26
DUF5401 super family cl38662
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 389-541 3.82e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


The actual alignment was detected with superfamily member pfam17380:

Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 40.11  E-value: 3.82e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295317318  389 LPRKCKKELLAVKLRNRPSKQELEDRnifpRRTDEERQEIRQQIEMKLSKlSQRPAVEELERRNILKQRNDQTEQEERRE 468
Cdd:pfam17380 479 LEKEKRDRKRAEEQRRKILEKELEER----KQAMIEEERKRKLLEKEMEE-RQKAIYEEERRREAEEERRKQQEMEERRR 553

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 295317318  469 IKQRLTRKLNQRPTVDELRDRKILIRfsdyvevARAQDYDRRADKPWTRLSAADKAAIRKELNEYKSNEMEVH 541
Cdd:pfam17380 554 IQEQMRKATEERSRLEAMEREREMMR-------QIVESEKARAEYEATTPITTIKPIYRPRISEYQPPDVESH 619
 
Name Accession Description Interval E-value
RPEL smart00707
Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;
436-458 1.09e-03

Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;


Pssm-ID: 128947  Cd Length: 26  Bit Score: 36.30  E-value: 1.09e-03
                           10        20
                   ....*....|....*....|...
gi 295317318   436 LSKLSQRPAVEELERRNILKQRN 458
Cdd:smart00707   4 NRKLSQRPTREELEERNILKELS 26
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 389-541 3.82e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 40.11  E-value: 3.82e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295317318  389 LPRKCKKELLAVKLRNRPSKQELEDRnifpRRTDEERQEIRQQIEMKLSKlSQRPAVEELERRNILKQRNDQTEQEERRE 468
Cdd:pfam17380 479 LEKEKRDRKRAEEQRRKILEKELEER----KQAMIEEERKRKLLEKEMEE-RQKAIYEEERRREAEEERRKQQEMEERRR 553

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 295317318  469 IKQRLTRKLNQRPTVDELRDRKILIRfsdyvevARAQDYDRRADKPWTRLSAADKAAIRKELNEYKSNEMEVH 541
Cdd:pfam17380 554 IQEQMRKATEERSRLEAMEREREMMR-------QIVESEKARAEYEATTPITTIKPIYRPRISEYQPPDVESH 619
RPEL pfam02755
RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL ...
 438-455 7.44e-03

RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL motif binds to actin.


Pssm-ID: 460677  Cd Length: 24  Bit Score: 34.17  E-value: 7.44e-03
                          10
                  ....*....|....*...
gi 295317318  438 KLSQRPAVEELERRNILK 455
Cdd:pfam02755   5 KLSHRPTREELVERNILP 22
 
Name Accession Description Interval E-value
RPEL smart00707
Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;
436-458 1.09e-03

Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;


Pssm-ID: 128947  Cd Length: 26  Bit Score: 36.30  E-value: 1.09e-03
                           10        20
                   ....*....|....*....|...
gi 295317318   436 LSKLSQRPAVEELERRNILKQRN 458
Cdd:smart00707   4 NRKLSQRPTREELEERNILKELS 26
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 389-541 3.82e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 40.11  E-value: 3.82e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295317318  389 LPRKCKKELLAVKLRNRPSKQELEDRnifpRRTDEERQEIRQQIEMKLSKlSQRPAVEELERRNILKQRNDQTEQEERRE 468
Cdd:pfam17380 479 LEKEKRDRKRAEEQRRKILEKELEER----KQAMIEEERKRKLLEKEMEE-RQKAIYEEERRREAEEERRKQQEMEERRR 553

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 295317318  469 IKQRLTRKLNQRPTVDELRDRKILIRfsdyvevARAQDYDRRADKPWTRLSAADKAAIRKELNEYKSNEMEVH 541
Cdd:pfam17380 554 IQEQMRKATEERSRLEAMEREREMMR-------QIVESEKARAEYEATTPITTIKPIYRPRISEYQPPDVESH 619
RPEL pfam02755
RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL ...
 438-455 7.44e-03

RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL motif binds to actin.


Pssm-ID: 460677  Cd Length: 24  Bit Score: 34.17  E-value: 7.44e-03
                          10
                  ....*....|....*...
gi 295317318  438 KLSQRPAVEELERRNILK 455
Cdd:pfam02755   5 KLSHRPTREELVERNILP 22
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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