Pdgfc platelet-derived growth factor, C polypeptide [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pdgfcprovided by MGI
Official Full Name: platelet-derived growth factor, C polypeptideprovided by MGI
Primary source: MGI:MGI:1859631
See related: Ensembl:ENSMUSG00000028019 AllianceGenome:MGI:1859631
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SCDGF; PDGF-C; VEGF-E; 1110064L01Rik
Summary: Enables platelet-derived growth factor receptor binding activity. Involved in positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including cellular response to amino acid stimulus; platelet-derived growth factor receptor signaling pathway; and regulation of protein phosphorylation. Located in extracellular region. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Orthologous to human PDGFC (platelet derived growth factor C). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in limb E14.5 (RPKM 8.7), ovary adult (RPKM 5.3) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 E3; 3 35.73 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (80943723..81121347)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (81036416..81214040)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PDGF-C promotes cell proliferation partially via downregulating BOP1.
Title: PDGF-C promotes cell proliferation partially via downregulating BOP1.
Age-associated microenvironmental changes highlight the role of PDGF-C in ER[+] breast cancer metastatic relapse.
Title: Age-associated microenvironmental changes highlight the role of PDGF-C in ER(+) breast cancer metastatic relapse.
Severe cerebellar malformations in mutant mice demonstrate a role for PDGF-C/PDGFRalpha signalling in cerebellar development.
Title: Severe cerebellar malformations in mutant mice demonstrate a role for PDGF-C/PDGFRα signalling in cerebellar development.
Role of platelet-derived growth factor c on endothelial dysfunction in cardiovascular diseases.
Title: Role of platelet-derived growth factor c on endothelial dysfunction in cardiovascular diseases.
Expression and function of PDGF-C in development and stem cells.
Title: Expression and function of PDGF-C in development and stem cells.
Blocking PDGF-CC signaling ameliorates multiple sclerosis-like neuroinflammation by inhibiting disruption of the blood-brain barrier.
Title: Blocking PDGF-CC signaling ameliorates multiple sclerosis-like neuroinflammation by inhibiting disruption of the blood-brain barrier.
In addition to its key role in mediating renal fibrosis, study identified PDGF-C as a mediator of hypertension via effects on renal vasculature and on the renin-angiotensin system in "Alport" mice, a model of progressive renal fibrosis.
Title: Identification of platelet-derived growth factor C as a mediator of both renal fibrosis and hypertension.
paracrine crosstalk between cancer cells expressing platelet-derived growth factor (PDGF)-CC and cancer-associated fibroblasts expressing the cognate receptors in human basal-like mammary carcinomas, was identified.
Title: Microenvironmental control of breast cancer subtype elicited through paracrine platelet-derived growth factor-CC signaling.
Results provide both in vitro and in vivo evidence that Mac-1 acting together with LRP1 facilitates PDGF-CC activation by thrombolytic tissue plasminogen activator in the neurovascular unit. The requirement of both Mac-1 and LRP1 for efficient activation of PDGF-CC by tPA provides a novel mechanism that helps limit PDGFRalpha signaling in the neurovascular unit.
Title: Microglial-mediated PDGF-CC activation increases cerebrovascular permeability during ischemic stroke.
High glucose-mediated induction of PDGF-C via ChREBP in mesangial cells contributes to the development of glomerular mesangial expansion in diabetes.
Title: High glucose induces platelet-derived growth factor-C via carbohydrate response element-binding protein in glomerular mesangial cells.

Submit: New GeneRIF Correction See all GeneRIFs (30)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (1)
Targeted (8) 1 citation

General gene information

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Markers

D3Dcr10 (e-PCR), detects polymorphism
- UniSTS:507660

D3Dcr9 (e-PCR), detects polymorphism
- UniSTS:507681

D3Mit358 (e-PCR), detects polymorphism
- UniSTS:142393

D3Mit245 (e-PCR), detects polymorphism
- UniSTS:129667

AW549711 (e-PCR)
- UniSTS:207512

AI647969 (e-PCR)
- UniSTS:178850

NoName (e-PCR)
- UniSTS:234712

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables platelet-derived growth factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables platelet-derived growth factor receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables platelet-derived growth factor receptor binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within activation of transmembrane receptor protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within animal organ morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within animal organ morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within bone development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cellular response to amino acid stimulus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within digestive tract development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of fibroblast proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in platelet-derived growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within platelet-derived growth factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in platelet-derived growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of MAP kinase activity	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of cell division	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cold-induced thermogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of fibroblast proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of fibroblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of protein autophosphorylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: platelet-derived growth factor C

Names: fallotein; spinal cord-derived growth factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001357746.1 → NP_001344675.1 platelet-derived growth factor C isoform 2

Status: VALIDATED

Source sequence(s)

AC122835, CD741441

Conserved Domains (2) summary

cd00041
Location:4 → 92

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00135
Location:178 → 270

PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and ...
NM_019971.3 → NP_064355.1 platelet-derived growth factor C isoform 1 precursor

See identical proteins and their annotated locations for NP_064355.1

Status: VALIDATED

Source sequence(s)

AF266467, CD741441

Consensus CDS

CCDS17425.1

UniProtKB/Swiss-Prot

Q8CI19, Q99JM4, Q9JHV8, Q9QY71

Related

ENSMUSP00000029652.3, ENSMUST00000029652.4

Conserved Domains (2) summary

cd00041
Location:49 → 162

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00135
Location:248 → 340

PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and ...