1PDG,1FZV,1FLT


Conserved Protein Domain Family
PDGF
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cd00135: PDGF 
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Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and somatic angiogenesis with a unique specificity for vascular endothelial cells; VEGF forms homodimers and exists in 4 different isoforms; overall, the VEGF monomer resembles that of PDGF, but its N-terminal segment is helical rather than extended; the cysteine knot motif is a common feature of this domain
Links
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Statistics
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PSSM-Id: 238079
Aligned: 18 rows
Threshold Bit Score: 80.8764
Created: 1-Nov-2000
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:cysteine knot motif
Evidence:
  • Comment:formed by two sets of disulfide bridges with a third passing through it
  • Citation:PMID 1396586
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1       #                                #       #         #                          
1PDG_A     14 AECKTRTEVFEISRRLidrtnanfLVWPPCVEVQRC---SGC-Cn---NRNVQCRPTQVQLRPVQVRKIEivr-----kk 81  human
1FLT_W     13 SYCHPIETLVDIFQEYpde--ieyIFKPSCVPLMRC---GGC-Cn---DEGLECVPTEESNITMQIMRIKph-------- 75  human
NP_497461 112 DTCNLQSVCVPIPQLSddp---qvLMYPKCYEVKQCv--GSC-C----NSVETCHPGTINLVKKHVAELLyign---grf 178 Caenorhabditis ele...
BAB18920  270 YSCTPRNHSVNLREELklt---naVFFPRCLLVQRCg--GNCgCgtlnWKSCTCSSGKTVKKYHEVLKFEpghfkrrgka 344 Norway rat
AAL91088  295 ATCRIPQKRCQLVQQDps-----kIYTPHCTILHRCsedSGC-Cp---SRSQICAAKSTHNVELHFFVKSsk-------- 357 fruit fly
NP_612270  27 SSCQPRPTKVALSGYD--------MYLPACTYVPRC---GGC-Cs--gDEATTCRPTATSAVNVTAFKLAf--------- 83  infectious spleen ...
NP_523407 140 ASCSPQPTIVELKPPAede--anyYYMPACTRISRC---NGC-Cg---STLISCQPTEVEQVQLRVRKVDraa-----ts 205 fruit fly
1718159    44 SGCKPRDTVVYLGEEYpes--tnlQYNPRCVTVKRC---SGC-Cn---GDGQICTAVETRNTTVTVSVTGvssssgtnsg 114 orf virus (strain ...
1709615    94 AVCKTRTVIYEIPRSQvdptsanfLIWPPCVEVKRC---TGC-Cn---TSSVKCQPSRVHHRSVKVAKVEyvr-----kk 161 house mouse
P97946    114 TQCSPRETCVEVASELgkt--tntFFKPPCVNVFRC---GGC-Cn---EEGVMCMNTSTSYISKQLFEISvpl------t 178 house mouse

Feature 1                    # #   
1PDG_A     82 pIFKKATVTLEDHLACKCETV 102 human
1FLT_W     76 qGQHIGEMSFLQHNKCECRPK 96  human
NP_497461 179 mFNMTKEITMEEHTSCSCFDC 199 Caenorhabditis elegans
BAB18920  345 kNMALVDIQLDHHERCDCICS 365 Norway rat
AAL91088  358 hRSVIEKRIFVNHTECHCIER 378 fruit fly
NP_612270  84 rRTQQVVLSVVTHTACACKFK 104 infectious spleen and kidney necrosis virus
NP_523407 206 gRRPFTIITVEQHTQCRCDCR 226 fruit fly
1718159   115 vSTNLQRISVTEHTKCDCIGR 135 orf virus (strain NZ7)
1709615   162 pKLKEVQVRLEEHLECACATS 182 house mouse
P97946    179 sVPELVPVKIANHTGCKCLPT 199 house mouse

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