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Wdr70 WD repeat domain 70 [ Mus musculus (house mouse) ]

Gene ID: 545085, updated on 5-Mar-2024

Summary

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Official Symbol
Wdr70provided by MGI
Official Full Name
WD repeat domain 70provided by MGI
Primary source
MGI:MGI:1921020
See related
Ensembl:ENSMUSG00000039828 AllianceGenome:MGI:1921020
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4833422F06Rik
Summary
Predicted to enable enzyme binding activity. Predicted to be involved in regulation of DNA double-strand break processing and regulation of histone H2B conserved C-terminal lysine ubiquitination. Predicted to be active in nucleus and site of double-strand break. Orthologous to human WDR70 (WD repeat domain 70). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 7.9), testis adult (RPKM 7.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
15 A1; 15 3.82 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (7902536..8138787, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (7873055..8099209, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_37885 Neighboring gene glial cell line derived neurotrophic factor Neighboring gene STARR-seq mESC enhancer starr_37886 Neighboring gene basic transcription factor 3, pseudogene 16 Neighboring gene STARR-seq mESC enhancer starr_37887 Neighboring gene ribosomal protein L19, pseudogene 6 Neighboring gene STARR-positive B cell enhancer mm9_chr15:8047913-8048213 Neighboring gene STARR-seq mESC enhancer starr_37890 Neighboring gene STARR-seq mESC enhancer starr_37891 Neighboring gene STARR-seq mESC enhancer starr_37892 Neighboring gene nucleoporin 155 Neighboring gene STARR-seq mESC enhancer starr_37894 Neighboring gene ciliogenesis and planar polarity effector 1 Neighboring gene STARR-seq mESC enhancer starr_37895 Neighboring gene predicted gene, 46494 Neighboring gene predicted gene, 24144

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. DDB1 binds histone reader BRWD3 to activate the transcriptional cascade in adipogenesis and promote onset of obesity. Wang X, et al. Cell Rep, 2021 Jun 22. PMID 34161765
  2. Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Evsikov AV, et al. Genes Dev, 2006 Oct 1. PMID 17015433, Free PMC Article
  3. Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics. Federspiel JD, et al. Mol Cell Proteomics, 2019 Aug 9. PMID 31040226, Free PMC Article
  4. ATG5 is required for B cell polarization and presentation of particulate antigens. Arbogast F, et al. Autophagy, 2019 Feb. PMID 30196744, Free PMC Article
  5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in site of double-strand break IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
WD repeat-containing protein 70

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081402.1 → NP_001074871.1  WD repeat-containing protein 70 isoform 1

    See identical proteins and their annotated locations for NP_001074871.1

    Status: VALIDATED

    Source sequence(s)
    AC107747, AC123611, AC130656, AK159714
    Consensus CDS
    CCDS37033.1
    UniProtKB/Swiss-Prot
    Q3TWF6
    UniProtKB/TrEMBL
    G3X934
    Related
    ENSMUSP00000037340.7, ENSMUST00000045766.8
    Conserved Domains (2) summary
    sd00039
    Location:188 → 230
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:180 → 501
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. NM_001358788.1 → NP_001345717.1  WD repeat-containing protein 70 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC107747, AK167464, BC051482, DV662602
    Consensus CDS
    CCDS88730.1
    UniProtKB/TrEMBL
    Q6P8I3
    Related
    ENSMUSP00000154067.2, ENSMUST00000227371.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    7902536..8138787 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159521.1 → XP_036015414.1  WD repeat-containing protein 70 isoform X1

    UniProtKB/Swiss-Prot
    Q3TWF6
    UniProtKB/TrEMBL
    G3X934
    Conserved Domains (2) summary
    sd00039
    Location:188 → 230
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:180 → 501
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. XM_017316701.2 → XP_017172190.1  WD repeat-containing protein 70 isoform X2

    Conserved Domains (2) summary
    sd00039
    Location:20 → 68
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:17 → 285
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3TWF6.1 GenPept UniProtKB/Swiss-Prot:Q3TWF6

Gene LinkOut

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