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Conserved domains on  [gi|124487149|ref|NP_001074871|]
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WD repeat-containing protein 70 isoform 1 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
180-444 1.04e-30

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 124.64  E-value: 1.04e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487149 180 TLRHGTKTVSALGLDPSGARLVTGGYDYDVKFWDFAgmdaSFKAFRSLQPcecHQ--IKSLQYSNTGDMILVVSGSSQAK 257
Cdd:COG2319  157 TLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLA----TGKLLRTLTG---HTgaVRSVAFSPDGKLLASGSADGTVR 229

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487149 258 VIDRDGFEVMecikgdqyivdmANTKGHTAMLHTGSWHPKikGEFM-TCSNDATVRLWEVENPKKqksvfkPRTMQGKKV 336
Cdd:COG2319  230 LWDLATGKLL------------RTLTGHSGSVRSVAFSPD--GRLLaSGSADGTVRLWDLATGEL------LRTLTGHSG 289

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487149 337 IPTTCTYSRDGNLVAAACQNGSIQIWDRNLTVHPKFHykQAHDPgtDTSCVAFSYDGNVLASRGGDDTLKLWDVRqfnkp 416
Cdd:COG2319  290 GVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTL--TGHTG--AVRSVAFSPDGKTLASGSDDGTVRLWDLA----- 360

                        250       260       270
                 ....*....|....*....|....*....|..
gi 124487149 417 lfSASDLPTLF----PMTDCCFSPDDKLIVTG 444
Cdd:COG2319  361 --TGELLRTLTghtgAVTSVAFSPDGRTLASG 390
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
180-444 1.04e-30

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 124.64  E-value: 1.04e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487149 180 TLRHGTKTVSALGLDPSGARLVTGGYDYDVKFWDFAgmdaSFKAFRSLQPcecHQ--IKSLQYSNTGDMILVVSGSSQAK 257
Cdd:COG2319  157 TLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLA----TGKLLRTLTG---HTgaVRSVAFSPDGKLLASGSADGTVR 229

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487149 258 VIDRDGFEVMecikgdqyivdmANTKGHTAMLHTGSWHPKikGEFM-TCSNDATVRLWEVENPKKqksvfkPRTMQGKKV 336
Cdd:COG2319  230 LWDLATGKLL------------RTLTGHSGSVRSVAFSPD--GRLLaSGSADGTVRLWDLATGEL------LRTLTGHSG 289

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487149 337 IPTTCTYSRDGNLVAAACQNGSIQIWDRNLTVHPKFHykQAHDPgtDTSCVAFSYDGNVLASRGGDDTLKLWDVRqfnkp 416
Cdd:COG2319  290 GVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTL--TGHTG--AVRSVAFSPDGKTLASGSDDGTVRLWDLA----- 360

                        250       260       270
                 ....*....|....*....|....*....|..
gi 124487149 417 lfSASDLPTLF----PMTDCCFSPDDKLIVTG 444
Cdd:COG2319  361 --TGELLRTLTghtgAVTSVAFSPDGRTLASG 390
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 180-501 1.33e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 118.59  E-value: 1.33e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487149 180 TLRHGTKTVSALGLDPSGARLVTGGYDYDVKFWDFAGMDAsfkaFRSLQPcecHQ--IKSLQYSNTGDMILVVSGSSQAK 257
Cdd:cd00200    4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGEL----LRTLKG---HTgpVRDVAASADGTYLASGSSDKTIR 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487149 258 VIDRDGFEVMECIKGdqyivdmantkgHTAMLHTGSWHPKikGEFM-TCSNDATVRLWEVENPKKQKsvfkprTMQGKKV 336
Cdd:cd00200   77 LWDLETGECVRTLTG------------HTSYVSSVAFSPD--GRILsSSSRDKTIKVWDVETGKCLT------TLRGHTD 136

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487149 337 IPTTCTYSRDGNLVAAACQNGSIQIWD-------RNLTVHpkfhykqahdpgTDT-SCVAFSYDGNVLASRGGDDTLKLW 408
Cdd:cd00200  137 WVNSVAFSPDGTFVASSSQDGTIKLWDlrtgkcvATLTGH------------TGEvNSVAFSPDGEKLLSSSSDGTIKLW 204

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487149 409 DVRQFN--KPLFSASDlptlfPMTDCCFSPDDKLIVTGTsvqrgcGSGKLVFLERRTFQRVYEIHITDASVVRCLWHPKL 486
Cdd:cd00200  205 DLSTGKclGTLRGHEN-----GVNSVAFSPDGYLLASGS------EDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDG 273

                        330
                 ....*....|....*
gi 124487149 487 NQIMVGTGNGLAKVY 501
Cdd:cd00200  274 KRLASGSADGTIRIW 288
PTZ00420 PTZ00420
coronin; Provisional
 283-421 4.42e-09

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 59.58  E-value: 4.42e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487149 283 KGHTAMLHTGSWHPKikGEFMTCSN--DATVRLWEVENPKKQKSVFKPRTMQGKKvipttctYSRDGNLVAAACQNGSIQ 360
Cdd:PTZ00420 122 KGHKKKISIIDWNPM--NYYIMCSSgfDSFVNIWDIENEKRAFQINMPKKLSSLK-------WNIKGNLLSGTCVGKHMH 192

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 124487149 361 IWD-RNLTVHPKFHykqAHDPGTDTSCV---AFSYDGNVLASRGGDDT----LKLWDVRQFNKPLFSAS 421
Cdd:PTZ00420 193 IIDpRKQEIASSFH---IHDGGKNTKNIwidGLGGDDNYILSTGFSKNnmreMKLWDLKNTTSALVTMS 258
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 180-213 8.17e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 8.17e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 124487149   180 TLRHGTKTVSALGLDPSGARLVTGGYDYDVKFWD 213
Cdd:smart00320   7 TLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
385-409 3.49e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.78  E-value: 3.49e-03
                          10        20
                  ....*....|....*....|....*
gi 124487149  385 SCVAFSYDGNVLASRGGDDTLKLWD 409
Cdd:pfam00400  15 TSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
180-444 1.04e-30

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 124.64  E-value: 1.04e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487149 180 TLRHGTKTVSALGLDPSGARLVTGGYDYDVKFWDFAgmdaSFKAFRSLQPcecHQ--IKSLQYSNTGDMILVVSGSSQAK 257
Cdd:COG2319  157 TLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLA----TGKLLRTLTG---HTgaVRSVAFSPDGKLLASGSADGTVR 229

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487149 258 VIDRDGFEVMecikgdqyivdmANTKGHTAMLHTGSWHPKikGEFM-TCSNDATVRLWEVENPKKqksvfkPRTMQGKKV 336
Cdd:COG2319  230 LWDLATGKLL------------RTLTGHSGSVRSVAFSPD--GRLLaSGSADGTVRLWDLATGEL------LRTLTGHSG 289

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487149 337 IPTTCTYSRDGNLVAAACQNGSIQIWDRNLTVHPKFHykQAHDPgtDTSCVAFSYDGNVLASRGGDDTLKLWDVRqfnkp 416
Cdd:COG2319  290 GVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTL--TGHTG--AVRSVAFSPDGKTLASGSDDGTVRLWDLA----- 360

                        250       260       270
                 ....*....|....*....|....*....|..
gi 124487149 417 lfSASDLPTLF----PMTDCCFSPDDKLIVTG 444
Cdd:COG2319  361 --TGELLRTLTghtgAVTSVAFSPDGRTLASG 390
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 180-501 1.33e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 118.59  E-value: 1.33e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487149 180 TLRHGTKTVSALGLDPSGARLVTGGYDYDVKFWDFAGMDAsfkaFRSLQPcecHQ--IKSLQYSNTGDMILVVSGSSQAK 257
Cdd:cd00200    4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGEL----LRTLKG---HTgpVRDVAASADGTYLASGSSDKTIR 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487149 258 VIDRDGFEVMECIKGdqyivdmantkgHTAMLHTGSWHPKikGEFM-TCSNDATVRLWEVENPKKQKsvfkprTMQGKKV 336
Cdd:cd00200   77 LWDLETGECVRTLTG------------HTSYVSSVAFSPD--GRILsSSSRDKTIKVWDVETGKCLT------TLRGHTD 136

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487149 337 IPTTCTYSRDGNLVAAACQNGSIQIWD-------RNLTVHpkfhykqahdpgTDT-SCVAFSYDGNVLASRGGDDTLKLW 408
Cdd:cd00200  137 WVNSVAFSPDGTFVASSSQDGTIKLWDlrtgkcvATLTGH------------TGEvNSVAFSPDGEKLLSSSSDGTIKLW 204

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487149 409 DVRQFN--KPLFSASDlptlfPMTDCCFSPDDKLIVTGTsvqrgcGSGKLVFLERRTFQRVYEIHITDASVVRCLWHPKL 486
Cdd:cd00200  205 DLSTGKclGTLRGHEN-----GVNSVAFSPDGYLLASGS------EDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDG 273

                        330
                 ....*....|....*
gi 124487149 487 NQIMVGTGNGLAKVY 501
Cdd:cd00200  274 KRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
180-446 1.36e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 121.56  E-value: 1.36e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487149 180 TLRHGTKTVSALGLDPSGARLVTGGYDYDVKFWDFAgmdaSFKAFRSLQPcecHQ--IKSLQYSNTGDMILVVSGSSQAK 257
Cdd:COG2319  115 TLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLA----TGKLLRTLTG---HSgaVTSVAFSPDGKLLASGSDDGTVR 187

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487149 258 VIDRDGFEVMecikgdqyivdmANTKGHTAMLHTGSWHPKikGEFM-TCSNDATVRLWEVENPKKqksvfkPRTMQGKKV 336
Cdd:COG2319  188 LWDLATGKLL------------RTLTGHTGAVRSVAFSPD--GKLLaSGSADGTVRLWDLATGKL------LRTLTGHSG 247

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487149 337 IPTTCTYSRDGNLVAAACQNGSIQIWDRNltvHPKFHYKQAHDPGTDTScVAFSYDGNVLASRGGDDTLKLWDVRQfNKP 416
Cdd:COG2319  248 SVRSVAFSPDGRLLASGSADGTVRLWDLA---TGELLRTLTGHSGGVNS-VAFSPDGKLLASGSDDGTVRLWDLAT-GKL 322

                        250       260       270
                 ....*....|....*....|....*....|
gi 124487149 417 LFSASDLPTlfPMTDCCFSPDDKLIVTGTS 446
Cdd:COG2319  323 LRTLTGHTG--AVRSVAFSPDGKTLASGSD 350
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 180-409 4.77e-26

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 108.58  E-value: 4.77e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487149 180 TLRHGTKTVSALGLDPSGARLVTGGYDYDVKFWDFAgmdasfkAFRSLQPCECHQ--IKSLQYSNTGDMILVVSGSSQAK 257
Cdd:cd00200   88 TLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVE-------TGKCLTTLRGHTdwVNSVAFSPDGTFVASSSQDGTIK 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487149 258 VIDrdgFEVMECIKgdqyivdmaNTKGHTAMLHTGSWHPKiKGEFMTCSNDATVRLWEVENPKKQKsvfkprTMQGKKVI 337
Cdd:cd00200  161 LWD---LRTGKCVA---------TLTGHTGEVNSVAFSPD-GEKLLSSSSDGTIKLWDLSTGKCLG------TLRGHENG 221

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 124487149 338 PTTCTYSRDGNLVAAACQNGSIQIWD-RNLTVHPKFhykQAHDPGTdtSCVAFSYDGNVLASRGGDDTLKLWD 409
Cdd:cd00200  222 VNSVAFSPDGYLLASGSEDGTIRVWDlRTGECVQTL---SGHTNSV--TSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
180-411 6.15e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 110.77  E-value: 6.15e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487149 180 TLRHGTKTVSALGLDPSGARLVTGGYDYDVKFWDFAGMdasfKAFRSLQPCEcHQIKSLQYSNTGDMILVVSGSSQAKVI 259
Cdd:COG2319  199 TLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATG----KLLRTLTGHS-GSVRSVAFSPDGRLLASGSADGTVRLW 273

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487149 260 DRDGFEVMECIKGdqyivdmantkgHTAMLHTGSWHPKikGEFM-TCSNDATVRLWEVENPKKqksvfkPRTMQGKKVIP 338
Cdd:COG2319  274 DLATGELLRTLTG------------HSGGVNSVAFSPD--GKLLaSGSDDGTVRLWDLATGKL------LRTLTGHTGAV 333

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 124487149 339 TTCTYSRDGNLVAAACQNGSIQIWDRNlTVHPKFHYKQAHDPGTDtscVAFSYDGNVLASRGGDDTLKLWDVR 411
Cdd:COG2319  334 RSVAFSPDGKTLASGSDDGTVRLWDLA-TGELLRTLTGHTGAVTS---VAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
171-501 1.20e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 100.76  E-value: 1.20e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487149 171 QRIPDSHEITLRHGTKTVSALGLDPSGARLVTGGYDYDVKFWDFAGMDASFKAFRSLQPcechqIKSLQYSNTGDMILVV 250
Cdd:COG2319   22 AAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA-----VLSVAFSPDGRLLASA 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487149 251 SGSSQAKVIDRDGFEVMecikgdqyivdmANTKGHTAMLHTGSWHPKikGEFM-TCSNDATVRLWEVENPKKqksvfkPR 329
Cdd:COG2319   97 SADGTVRLWDLATGLLL------------RTLTGHTGAVRSVAFSPD--GKTLaSGSADGTVRLWDLATGKL------LR 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487149 330 TMQGKKVIPTTCTYSRDGNLVAAACQNGSIQIWD-------RNLTVHPKFHYkqahdpgtdtsCVAFSYDGNVLASRGGD 402
Cdd:COG2319  157 TLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDlatgkllRTLTGHTGAVR-----------SVAFSPDGKLLASGSAD 225

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487149 403 DTLKLWDVRQfNKPLFSASDLPtlFPMTDCCFSPDDKLIVTGTsvqrgcGSGKLVFLERRTFQRVYEIHITDASVVRCLW 482
Cdd:COG2319  226 GTVRLWDLAT-GKLLRTLTGHS--GSVRSVAFSPDGRLLASGS------ADGTVRLWDLATGELLRTLTGHSGGVNSVAF 296

                        330
                 ....*....|....*....
gi 124487149 483 HPKLNQIMVGTGNGLAKVY 501
Cdd:COG2319  297 SPDGKLLASGSDDGTVRLW 315
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 329-501 9.18e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 69.29  E-value: 9.18e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487149 329 RTMQGKKVIPTTCTYSRDGNLVAAACQNGSIQIWDRNlTVHPKFHYKQAHDPGTDTSCVAfsyDGNVLASRGGDDTLKLW 408
Cdd:cd00200    3 RTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLE-TGELLRTLKGHTGPVRDVAASA---DGTYLASGSSDKTIRLW 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487149 409 DVRQfNKPLFsasdlpTLF----PMTDCCFSPDDKLIVTGTSvqrgcgSGKLVFLERRTFQRVYEIHITDASVVRCLWHP 484
Cdd:cd00200   79 DLET-GECVR------TLTghtsYVSSVAFSPDGRILSSSSR------DKTIKVWDVETGKCLTTLRGHTDWVNSVAFSP 145

                        170
                 ....*....|....*..
gi 124487149 485 KLNQIMVGTGNGLAKVY 501
Cdd:cd00200  146 DGTFVASSSQDGTIKLW 162
WD40 COG2319
WD40 repeat [General function prediction only];
180-318 2.56e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 63.01  E-value: 2.56e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487149 180 TLRHGTKTVSALGLDPSGARLVTGGYDYDVKFWDFAgmdaSFKAFRSLQPcECHQIKSLQYSNTGDMILVVSGSSQAKVI 259
Cdd:COG2319  283 TLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA----TGKLLRTLTG-HTGAVRSVAFSPDGKTLASGSDDGTVRLW 357

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487149 260 DRDGFEVMecikgdqyivdmANTKGHTAMLHTGSWHPKikGEFM-TCSNDATVRLWEVEN 318
Cdd:COG2319  358 DLATGELL------------RTLTGHTGAVTSVAFSPD--GRTLaSGSADGTVRLWDLAT 403
PTZ00420 PTZ00420
coronin; Provisional
 283-421 4.42e-09

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 59.58  E-value: 4.42e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487149 283 KGHTAMLHTGSWHPKikGEFMTCSN--DATVRLWEVENPKKQKSVFKPRTMQGKKvipttctYSRDGNLVAAACQNGSIQ 360
Cdd:PTZ00420 122 KGHKKKISIIDWNPM--NYYIMCSSgfDSFVNIWDIENEKRAFQINMPKKLSSLK-------WNIKGNLLSGTCVGKHMH 192

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 124487149 361 IWD-RNLTVHPKFHykqAHDPGTDTSCV---AFSYDGNVLASRGGDDT----LKLWDVRQFNKPLFSAS 421
Cdd:PTZ00420 193 IIDpRKQEIASSFH---IHDGGKNTKNIwidGLGGDDNYILSTGFSKNnmreMKLWDLKNTTSALVTMS 258
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 180-213 8.17e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 8.17e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 124487149   180 TLRHGTKTVSALGLDPSGARLVTGGYDYDVKFWD 213
Cdd:smart00320   7 TLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
CDC55 COG5170
Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms];
301-445 1.13e-03

Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms];


Pssm-ID: 227498 [Multi-domain]  Cd Length: 460  Bit Score: 41.94  E-value: 1.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487149 301 EFMTCSNDATVRLWEVENPKKQKSV--FKPRTMQG-KKVIPTTCTYSRDGNLVAAACQNGSIQIWD---RNLTVHPKFHY 374
Cdd:COG5170  185 ETLLSADDLRINLWNLEIIDGSFNIvdIKPHNMEElTEVITSAEFHPEMCNVFMYSSSKGEIKLNDlrqSALCDNSKKLF 264

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487149 375 KQAHDPG---------TDTSCVAFSYDGNVLASRGGDdTLKLWDVRQFNKPLFSASDLPTL-------------FPMTDC 432
Cdd:COG5170  265 ELTIDGVdvdffeeivSSISDFKFSDNGRYILSRDYL-TVKIWDVNMAKNPIKTIPMHCDLmdelndvyendaiFDKFEI 343

                        170
                 ....*....|...
gi 124487149 433 CFSPDDKLIVTGT 445
Cdd:COG5170  344 SFSGDDKHVLSGS 356
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 385-409 2.15e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.14  E-value: 2.15e-03
                           10        20
                   ....*....|....*....|....*
gi 124487149   385 SCVAFSYDGNVLASRGGDDTLKLWD 409
Cdd:smart00320  16 TSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
385-409 3.49e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.78  E-value: 3.49e-03
                          10        20
                  ....*....|....*....|....*
gi 124487149  385 SCVAFSYDGNVLASRGGDDTLKLWD 409
Cdd:pfam00400  15 TSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
180-213 4.88e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.01  E-value: 4.88e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 124487149  180 TLRHGTKTVSALGLDPSGARLVTGGYDYDVKFWD 213
Cdd:pfam00400   6 TLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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