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Gspt1 G1 to S phase transition 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24420, updated on 5-Mar-2024

Summary

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Symbol
Gspt1provided by RGD
Full Name
G1 to S phase transition 1provided by RGD
Primary source
RGD:2751
See related
Ensembl:ENSRNOG00000046271 AllianceGenome:RGD:2751
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable GTPase activity and translation release factor activity. Predicted to be involved in cytoplasmic translational termination and regulation of translational termination. Predicted to act upstream of or within protein methylation. Predicted to be located in cytosol. Predicted to be part of translation release factor complex. Orthologous to human GSPT1 (G1 to S phase transition 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 355.4), Adrenal (RPKM 354.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
10q11
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (4867687..4904186)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (4362528..4397215)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (4313100..4347661)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene sorting nexin 29 Neighboring gene uncharacterized LOC134480744 Neighboring gene TNF receptor superfamily member 17 Neighboring gene uncharacterized LOC120095016 Neighboring gene uncharacterized LOC100911627 Neighboring gene ribosomal L1 domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. [Human transmissible dementia: prion diseases?]. Dreux C, et al. Bull Acad Natl Med, 1992 Nov. PMID 1300226
  2. The effect of eukaryotic release factor depletion on translation termination in human cell lines. Janzen DM, et al. Nucleic Acids Res, 2004. PMID 15326224, Free PMC Article
  3. Regulation of HIV-1 Gag-Pol Expression by Shiftless, an Inhibitor of Programmed -1 Ribosomal Frameshifting. Wang X, et al. Cell, 2019 Jan 24. PMID 30682371, Free PMC Article
  4. Molecular cloning of a novel member of the eukaryotic polypeptide chain-releasing factors (eRF). Its identification as eRF3 interacting with eRF1. Hoshino S, et al. J Biol Chem, 1998 Aug 28. PMID 9712840
  5. The polypeptide chain-releasing factor GSPT1/eRF3 is proteolytically processed into an IAP-binding protein. Hegde R, et al. J Biol Chem, 2003 Oct 3. PMID 12865429

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC94063

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
  
enables translation release factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation release factor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in regulation of translational termination ISO
Inferred from Sequence Orthology
more info
  
involved_in translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translational termination ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytosolic ribosome ISO
Inferred from Sequence Orthology
more info
  
part_of translation release factor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of translation release factor complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
eukaryotic peptide chain release factor GTP-binding subunit ERF3A
Names
G1 to S phase transition protein 1
G1 to phase transition 1
eukaryotic peptide chain release factor GTP-binding subunit ERF3B-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003978.1 → NP_001003978.1  eukaryotic peptide chain release factor GTP-binding subunit ERF3A

    See identical proteins and their annotated locations for NP_001003978.1

    Status: PROVISIONAL

    Source sequence(s)
    BC079092
    UniProtKB/TrEMBL
    F7F6J0, M0RC00, Q6AYD5
    Related
    ENSRNOP00000067103.1, ENSRNOT00000074487.3
    Conserved Domains (5) summary
    cd01883
    Location:213 → 429
    EF1_alpha; Elongation Factor 1-alpha (EF1-alpha) protein family
    COG5256
    Location:209 → 633
    TEF1; Translation elongation factor EF-1alpha (GTPase) [Translation, ribosomal structure and biogenesis]
    pfam07145
    Location:62 → 79
    PAM2; Ataxin-2 C-terminal region
    cd04089
    Location:438 → 519
    eRF3_II; Domain II of the eukaryotic class II release factor
    cd03704
    Location:525 → 631
    eRF3_C_III; C-terminal domain of eRF3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    4867687..4904186
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017596996.3 → XP_017452485.1  eukaryotic peptide chain release factor GTP-binding subunit ERF3A isoform X1

    UniProtKB/TrEMBL
    F7F6J0
    Conserved Domains (5) summary
    cd01883
    Location:212 → 428
    EF1_alpha; Elongation Factor 1-alpha (EF1-alpha) protein family
    COG5256
    Location:208 → 632
    TEF1; Translation elongation factor EF-1alpha (GTPase) [Translation, ribosomal structure and biogenesis]
    pfam07145
    Location:62 → 79
    PAM2; Ataxin-2 C-terminal region
    cd04089
    Location:437 → 518
    eRF3_II; Domain II of the eukaryotic class II release factor
    cd03704
    Location:524 → 630
    eRF3_C_III; C-terminal domain of eRF3
Nucleotide Protein Strain
Heading Accession and Version

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