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Nxt2 nuclear transport factor 2-like export factor 2 [ Mus musculus (house mouse) ]

Gene ID: 237082, updated on 5-Mar-2024

Summary

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Official Symbol
Nxt2provided by MGI
Official Full Name
nuclear transport factor 2-like export factor 2provided by MGI
Primary source
MGI:MGI:2147914
See related
Ensembl:ENSMUSG00000042271 AllianceGenome:MGI:2147914
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
P15-2; 6330587F24Rik
Summary
Predicted to be involved in protein import into nucleus. Predicted to act upstream of or within mRNA transport and protein transport. Located in nucleus and perinuclear region of cytoplasm. Orthologous to human NXT2 (nuclear transport factor 2 like export factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cerebellum adult (RPKM 8.0), bladder adult (RPKM 4.9) and 21 other tissues See more
Orthologs
human all
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Genomic context

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Location:
X F2; X 63.02 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (141009766..141022696)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (142226770..142239700)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene guanylate cyclase 2f Neighboring gene STARR-seq mESC enhancer starr_48017 Neighboring gene STARR-positive B cell enhancer mm9_chrX:138662261-138662562 Neighboring gene retinoblastoma binding protein 7 pseudogene Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene Neighboring gene potassium voltage-gated channel subfamily E regulatory subunit 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Genetic characterization of nuclear export factor NXT1 and its paralog NXT2 in primates and murine rodents. Hu J, et al. Zoology (Jena), 2022 Apr. PMID 35219094
  2. The fragile X mental retardation protein interacts with a distinct mRNA nuclear export factor NXF2. Lai D, et al. RNA, 2006 Aug. PMID 16790844, Free PMC Article
  3. The evolutionarily conserved genes: Tex37, Ccdc73, Prss55 and Nxt2 are dispensable for fertility in mice. Khan M, et al. Sci Rep, 2018 Mar 21. PMID 29563520, Free PMC Article
  4. Molecular cloning and functional characterization of mouse Nxf family gene products. Sasaki M, et al. Genomics, 2005 May. PMID 15820316
  5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Genetic characterization of nuclear export factor NXT1 and its paralog NXT2 in primates and murine rodents.
    Title: Genetic characterization of nuclear export factor NXT1 and its paralog NXT2 in primates and murine rodents.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within mRNA transport IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleocytoplasmic transport IEA
Inferred from Electronic Annotation
more info
  
involved_in poly(A)+ mRNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
part_of nuclear RNA export factor complex ISO
Inferred from Sequence Orthology
more info
  
part_of nuclear pore central transport channel IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
NTF2-related export protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001161430.2 → NP_001154902.1  NTF2-related export protein 2 isoform a

    See identical proteins and their annotated locations for NP_001154902.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    BB038253, BB857403, BC068166
    Consensus CDS
    CCDS41155.1
    UniProtKB/Swiss-Prot
    B1AVX3, B1AVX5, Q3UNA4, Q505F8, Q6NVE1, Q8C070
    Related
    ENSMUSP00000048221.6, ENSMUST00000042329.12
    Conserved Domains (1) summary
    cd00780
    Location:13 → 138
    NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...

  2. NM_001290532.1 → NP_001277461.1  NTF2-related export protein 2 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (b) has a longer N-terminus than isoform a.
    Source sequence(s)
    BB038253, BC068166, CJ148018
    Consensus CDS
    CCDS72440.1
    UniProtKB/TrEMBL
    Q6P250
    Related
    ENSMUSP00000108538.3, ENSMUST00000112916.9
    Conserved Domains (1) summary
    cd00780
    Location:69 → 194
    NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...

  3. NM_001290533.1 → NP_001277462.1  NTF2-related export protein 2 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) has a shorter N-terminus than isoform a.
    Source sequence(s)
    AL731672, BB038253, BC068166
    Consensus CDS
    CCDS72441.1
    UniProtKB/Swiss-Prot
    Q3UNA4
    Related
    ENSMUSP00000108535.2, ENSMUST00000112913.2
    Conserved Domains (1) summary
    cd00780
    Location:1 → 110
    NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...

  4. NM_172782.4 → NP_766370.2  NTF2-related export protein 2 isoform a

    See identical proteins and their annotated locations for NP_766370.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform a. Variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    BB038253, BB851047, BC068166
    Consensus CDS
    CCDS41155.1
    UniProtKB/Swiss-Prot
    B1AVX3, B1AVX5, Q3UNA4, Q505F8, Q6NVE1, Q8C070
    Related
    ENSMUSP00000108536.2, ENSMUST00000112914.8
    Conserved Domains (1) summary
    cd00780
    Location:13 → 138
    NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    141009766..141022696
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030251330.2 → XP_030107190.1  NTF2-related export protein 2 isoform X1

    UniProtKB/Swiss-Prot
    B1AVX3, B1AVX5, Q3UNA4, Q505F8, Q6NVE1, Q8C070
    Conserved Domains (1) summary
    cd00780
    Location:13 → 138
    NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...

  2. XM_030251331.2 → XP_030107191.1  NTF2-related export protein 2 isoform X1

    UniProtKB/Swiss-Prot
    B1AVX3, B1AVX5, Q3UNA4, Q505F8, Q6NVE1, Q8C070
    Conserved Domains (1) summary
    cd00780
    Location:13 → 138
    NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UNA4.1 GenPept UniProtKB/Swiss-Prot:Q3UNA4

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