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Nup188 nucleoporin 188 [ Mus musculus (house mouse) ]

Gene ID: 227699, updated on 9-Dec-2024

Summary

Official Symbol
Nup188provided by MGI
Official Full Name
nucleoporin 188provided by MGI
Primary source
MGI:MGI:2446190
See related
Ensembl:ENSMUSG00000052533 AllianceGenome:MGI:2446190
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to be a structural constituent of nuclear pore. Predicted to be involved in RNA export from nucleus and protein import into nucleus. Predicted to be located in nuclear envelope. Predicted to be part of nuclear pore inner ring. Human ortholog(s) of this gene implicated in Sandestig-Stefanova syndrome and respiratory failure. Orthologous to human NUP188 (nucleoporin 188). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in testis adult (RPKM 50.6), thymus adult (RPKM 23.1) and 27 other tissues See more
Orthologs
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Genomic context

See Nup188 in Genome Data Viewer
Location:
2 B; 2 21.49 cM
Exon count:
46
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (30176419..30234278)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (30286407..30344266)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene phytanoyl-CoA dioxygenase domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E7805 Neighboring gene dolichol kinase Neighboring gene predicted gene, 39780 Neighboring gene SH3-domain GRB2-like endophilin B2 Neighboring gene mitoguardin 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Pathways from PubChem

Interactions

General gene information

Clone Names

  • KIAA0169

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in RNA export from nucleus  
involved_in mRNA transport  
involved_in nucleocytoplasmic transport PubMed 
involved_in protein import into nucleus  
involved_in protein import into nucleus  
involved_in protein import into nucleus  
Component Evidence Code Pubs
located_in nuclear envelope  
part_of nuclear pore PubMed 
part_of nuclear pore inner ring  

General protein information

Preferred Names
nucleoporin NUP188
Names
nucleoporin NUP188 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001410239.1NP_001397168.1  nucleoporin NUP188 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL954388
  2. NM_001410240.1NP_001397169.1  nucleoporin NUP188 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL954388
  3. NM_001410241.1NP_001397170.1  nucleoporin NUP188 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL954388
  4. NM_001410242.1NP_001397171.1  nucleoporin NUP188 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL954388
    UniProtKB/TrEMBL
    A2AWI5
    Related
    ENSMUSP00000109264.3, ENSMUST00000113634.3
  5. NM_001410243.1NP_001397172.1  nucleoporin NUP188 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL954388
    UniProtKB/TrEMBL
    F2Z4A7, J3JSA4
    Related
    ENSMUSP00000122398.2, ENSMUST00000138666.8
  6. NM_198304.4NP_938046.2  nucleoporin NUP188 isoform 1

    See identical proteins and their annotated locations for NP_938046.2

    Status: VALIDATED

    Source sequence(s)
    AL954388
    Consensus CDS
    CCDS15878.1
    UniProtKB/Swiss-Prot
    Q4VA15, Q6ZQH8, Q80UL4, Q8C7A1, Q8R3F1
    Related
    ENSMUSP00000065836.6, ENSMUST00000064447.12
    Conserved Domains (1) summary
    pfam10487
    Location:31941
    Nup188; Nucleoporin subcomplex protein binding to Pom34

RNA

  1. NR_156132.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL954388

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    30176419..30234278
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030249849.1XP_030105709.1  nucleoporin NUP188 isoform X1

    Conserved Domains (1) summary
    pfam10487
    Location:4828
    Nup188; Nucleoporin subcomplex protein binding to Pom34
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