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Kif7 kinesin family member 7 [ Mus musculus (house mouse) ]

Gene ID: 16576, updated on 21-Apr-2024

Summary

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Official Symbol
Kif7provided by MGI
Official Full Name
kinesin family member 7provided by MGI
Primary source
MGI:MGI:1098239
See related
Ensembl:ENSMUSG00000050382 AllianceGenome:MGI:1098239
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables identical protein binding activity. Involved in negative regulation of smoothened signaling pathway and positive regulation of smoothened signaling pathway. Acts upstream of or within aorta development; cardiac septum development; and coronary vasculature development. Located in ciliary basal body. Is expressed in metanephros and testis. Used to study acrocallosal syndrome; ciliopathy; congenital diaphragmatic hernia; and hydrolethalus syndrome. Human ortholog(s) of this gene implicated in acrocallosal syndrome; cleft lip; and hydrolethalus syndrome 2. Orthologous to human KIF7 (kinesin family member 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in limb E14.5 (RPKM 4.8), CNS E11.5 (RPKM 4.8) and 25 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 45.09 cM; 7 D2
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (79347846..79365520, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (79698098..79715772, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene Rhesus blood group-associated C glycoprotein Neighboring gene cullin 4B pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E10444 Neighboring gene STARR-seq mESC enhancer starr_19286 Neighboring gene STARR-positive B cell enhancer ABC_E551 Neighboring gene TOPBP1-interacting checkpoint and replication regulator Neighboring gene uncharacterized LOC118567517 Neighboring gene STARR-positive B cell enhancer mm9_chr7:86873152-86873453 Neighboring gene perilipin 1 Neighboring gene peroxisomal biogenesis factor 11 alpha

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Hedgehog-induced ciliary trafficking of kinesin-4 motor KIF7 requires intraflagellar transport but not KIF7's microtubule binding. Yue Y, et al. Mol Biol Cell, 2022 Jan 1. PMID 34705483, Free PMC Article
  2. The kinesin motor protein Kif7 is required for T-cell development and normal MHC expression on thymic epithelial cells (TEC) in the thymus. Lau CI, et al. Oncotarget, 2017 Apr 11. PMID 28445929, Free PMC Article
  3. Functional Assessment of Kinesin-7 CENP-E in Spermatocytes using In Vivo Inhibition, Immunofluorescence and Flow Cytometry. Xu MF, et al. J Vis Exp, 2021 Dec 28. PMID 35037651
  4. Altered chemomechanical coupling causes impaired motility of the kinesin-4 motors KIF27 and KIF7. Yue Y, et al. J Cell Biol, 2018 Apr 2. PMID 29351996, Free PMC Article
  5. TALPID3 controls centrosome and cell polarity and the human ortholog KIAA0586 is mutated in Joubert syndrome (JBTS23). Stephen LA, et al. Elife, 2015 Sep 19. PMID 26386247, Free PMC Article

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Functional Assessment of Kinesin-7 CENP-E in Spermatocytes using In Vivo Inhibition, Immunofluorescence and Flow Cytometry.
    Title: Functional Assessment of Kinesin-7 CENP-E in Spermatocytes using In Vivo Inhibition, Immunofluorescence and Flow Cytometry.
  2. Hedgehog-induced ciliary trafficking of kinesin-4 motor KIF7 requires intraflagellar transport but not KIF7's microtubule binding.
    Title: Hedgehog-induced ciliary trafficking of kinesin-4 motor KIF7 requires intraflagellar transport but not KIF7's microtubule binding.
  3. Evolutionarily selected sequence differences enable immotile KIF7 motors to function not as transporters but as microtubule-based tethers of signaling complexes.
    Title: Altered chemomechanical coupling causes impaired motility of the kinesin-4 motors KIF27 and KIF7.
  4. Kif7-deficient thymocytes were unable to interpret changes in the Hedgehog signal. In addition, Kif7-deficiency reduced cell-surface MHCII expression on thymic epithelial cells.
    Title: The kinesin motor protein Kif7 is required for T-cell development and normal MHC expression on thymic epithelial cells (TEC) in the thymus.
  5. Mouse UBR3 poly-ubiquitinates Kif7, the mammalian homologue of Cos2. Finally, loss of UBR3 up-regulates Kif7 protein levels and decreases Hh signaling in cultured cells.
    Title: Ubr3, a Novel Modulator of Hh Signaling Affects the Degradation of Costal-2 and Kif7 through Poly-ubiquitination.
  6. Our data suggest that Kif7 may function to regulate the maintenance of the respiratory airway architecture by controlling cellular density, cell proliferation, and cycle exit through its role as a microtubule associated protein.
    Title: KIF7 Controls the Proliferation of Cells of the Respiratory Airway through Distinct Microtubule Dependent Mechanisms.
  7. findings demonstrate that perturbations of Sufu and Kif7 affect Gli activity and recapitulate the full spectrum of vertebrate limb defects, ranging from severe truncation to polydactyly.
    Title: Sufu and Kif7 in limb patterning and development.
  8. results suggested that PPFIA1 functioned with PP2A to promote the dephosphorylation of Kif7, triggering Kif7 localization to the tips of primary cilia and promoting Gli transcriptional activity.
    Title: The PPFIA1-PP2A protein complex promotes trafficking of Kif7 to the ciliary tip and Hedgehog signaling.
  9. Kif7 localizes to the cilium tip, the site of microtubule plus ends, where it limits cilium length and controls cilium structure
    Title: The kinesin-4 protein Kif7 regulates mammalian Hedgehog signalling by organizing the cilium tip compartment.
  10. Knockdown of Kif7, and retinoic acid receptors alpha (Rara), beta (Rarb), and gamma (Rarg) indicated that RA signaling is dependent on these genes to promote tendonogenesis within the embryonic diaphragm.
    Title: Kif7 is required for the patterning and differentiation of the diaphragm in a model of syndromic congenital diaphragmatic hernia.
Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC176006

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule motor activity ISO
Inferred from Sequence Orthology
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within aorta development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cardiac septum development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within coronary vasculature development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of smoothened signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of smoothened signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in ciliary basal body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in ciliary tip IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cilium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cilium ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
part_of kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
kinesin-like protein KIF7
Names
kinesin 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291222.2 → NP_001278151.1  kinesin-like protein KIF7 isoform 1

    See identical proteins and their annotated locations for NP_001278151.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC158582
    Consensus CDS
    CCDS80739.1
    UniProtKB/Swiss-Prot
    B2RUB1, B7ZNG0
    UniProtKB/TrEMBL
    J3QNW9
    Related
    ENSMUSP00000139359.2, ENSMUST00000183846.8
    Conserved Domains (3) summary
    COG1196
    Location:734 → 1063
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    PRK11281
    Location:949 → 1202
    PRK11281; mechanosensitive channel MscK
    cd01372
    Location:15 → 350
    KISc_KIF4; Kinesin motor domain, KIF4-like subfamily

  2. NM_001412613.1 → NP_001399542.1  kinesin-like protein KIF7 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC158582

  3. NM_001412614.1 → NP_001399543.1  kinesin-like protein KIF7 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC158582

  4. NM_010626.3 → NP_034756.2  kinesin-like protein KIF7 isoform 2

    See identical proteins and their annotated locations for NP_034756.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.
    Source sequence(s)
    AC158582
    Consensus CDS
    CCDS52278.1
    UniProtKB/Swiss-Prot
    B2RUB1, B7ZNG0
    UniProtKB/TrEMBL
    E9QMU1
    Related
    ENSMUSP00000061806.7, ENSMUST00000059836.13
    Conserved Domains (3) summary
    COG1196
    Location:734 → 1062
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    PRK11281
    Location:948 → 1201
    PRK11281; mechanosensitive channel MscK
    cd01372
    Location:15 → 350
    KISc_KIF4; Kinesin motor domain, KIF4-like subfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    79347846..79365520 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006540666.1 → XP_006540729.1  kinesin-like protein KIF7 isoform X3

    UniProtKB/Swiss-Prot
    B2RUB1, B7ZNG0
    Conserved Domains (3) summary
    COG1196
    Location:733 → 1062
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    PRK11281
    Location:948 → 1201
    PRK11281; mechanosensitive channel MscK
    cd01372
    Location:15 → 350
    KISc_KIF4; Kinesin motor domain, KIF4-like subfamily

  2. XM_006540667.1 → XP_006540730.1  kinesin-like protein KIF7 isoform X2

    UniProtKB/Swiss-Prot
    B2RUB1, B7ZNG0
    Conserved Domains (3) summary
    COG1196
    Location:733 → 1062
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    PRK11281
    Location:948 → 1201
    PRK11281; mechanosensitive channel MscK
    cd01372
    Location:15 → 350
    KISc_KIF4; Kinesin motor domain, KIF4-like subfamily

  3. XM_006540668.1 → XP_006540731.1  kinesin-like protein KIF7 isoform X4

    See identical proteins and their annotated locations for XP_006540731.1

    UniProtKB/Swiss-Prot
    B2RUB1, B7ZNG0
    UniProtKB/TrEMBL
    E9QMU1
    Related
    ENSMUSP00000139224.2, ENSMUST00000184137.2
    Conserved Domains (3) summary
    COG1196
    Location:734 → 1062
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    PRK11281
    Location:948 → 1201
    PRK11281; mechanosensitive channel MscK
    cd01372
    Location:15 → 350
    KISc_KIF4; Kinesin motor domain, KIF4-like subfamily

  4. XM_006540665.4 → XP_006540728.1  kinesin-like protein KIF7 isoform X1

    See identical proteins and their annotated locations for XP_006540728.1

    UniProtKB/Swiss-Prot
    B2RUB1, B7ZNG0
    UniProtKB/TrEMBL
    J3QNW9
    Conserved Domains (3) summary
    COG1196
    Location:734 → 1063
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    PRK11281
    Location:949 → 1202
    PRK11281; mechanosensitive channel MscK
    cd01372
    Location:15 → 350
    KISc_KIF4; Kinesin motor domain, KIF4-like subfamily

  5. XM_006540670.5 → XP_006540733.1  kinesin-like protein KIF7 isoform X5

    Conserved Domains (2) summary
    COG1196
    Location:268 → 597
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    PRK11281
    Location:483 → 736
    PRK11281; mechanosensitive channel MscK

RNA

  1. XR_003946403.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B7ZNG0.1 GenPept UniProtKB/Swiss-Prot:B7ZNG0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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