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Trim26 tripartite motif-containing 26 [ Mus musculus (house mouse) ]

Gene ID: 22670, updated on 5-Mar-2024

Summary

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Official Symbol
Trim26provided by MGI
Official Full Name
tripartite motif-containing 26provided by MGI
Primary source
MGI:MGI:1337056
See related
Ensembl:ENSMUSG00000024457 AllianceGenome:MGI:1337056
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Zfp173; Zfp1736
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in several processes, including defense response to other organism; negative regulation of viral entry into host cell; and positive regulation of DNA-binding transcription factor activity. Predicted to act upstream of or within immune system process. Located in cytoplasm. Is expressed in genitourinary system. Orthologous to human TRIM26 (tripartite motif containing 26). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 19.3), spleen adult (RPKM 16.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
17 B1; 17 19.16 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (37148016..37170290)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (36837123..36859398)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene histocompatibility 2, M region locus 10.5 Neighboring gene histocompatibility 2, M region locus 10.6 Neighboring gene STARR-positive B cell enhancer ABC_E612 Neighboring gene predicted gene, 25973 Neighboring gene tripartite motif-containing 15 Neighboring gene tripartite motif-containing 10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Transforming Growth Factor β-Induced Proliferative Arrest Mediated by TRIM26-Dependent TAF7 Degradation and Its Antagonism by MYC. Nakagawa T, et al. Mol Cell Biol, 2018 Mar 1. PMID 29203640, Free PMC Article
  2. TRIM26 negatively regulates interferon-β production and antiviral response through polyubiquitination and degradation of nuclear IRF3. Wang P, et al. PLoS Pathog, 2015 Mar. PMID 25763818, Free PMC Article
  3. Jmjd3 inhibits reprogramming by upregulating expression of INK4a/Arf and targeting PHF20 for ubiquitination. Zhao W, et al. Cell, 2013 Feb 28. PMID 23452852, Free PMC Article
  4. BAC/YAC contigs from the H2-M region of mouse Chr 17 define gene order as Znf173-Tctex5-mog-D17Tu42-M3-M2. Yoshino M, et al. Immunogenetics, 1998 Apr. PMID 9510555
  5. The tripartite motif family identifies cell compartments. Reymond A, et al. EMBO J, 2001 May 1. PMID 11331580, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TRIM26 alleviates fatal immunopathology by regulating inflammatory neutrophil infiltration during Candida infection.
    Title: TRIM26 alleviates fatal immunopathology by regulating inflammatory neutrophil infiltration during Candida infection.
  2. Sustained exposure of cells to TGF-beta resulted in recovery from proliferative arrest in association with amplification of the Myc proto-oncogene, with MYC inhibiting TRIM26 induction by TGF-beta.
    Title: Transforming Growth Factor β-Induced Proliferative Arrest Mediated by TRIM26-Dependent TAF7 Degradation and Its Antagonism by MYC.
  3. Our findings delineate a novel mechanism for the termination of IRF3 activation in nucleus through TRIM26-mediated IRF3 ubiquitination and degradation.
    Title: TRIM26 negatively regulates interferon-β production and antiviral response through polyubiquitination and degradation of nuclear IRF3.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
  
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in innate immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of viral entry into host cell IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of viral entry into host cell ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of non-canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K11-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in suppression of viral release by host ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
tripartite motif-containing protein 26
Names
tripartite motif protein 26
tripartite motif protein TRIM26
zinc finger protein 173
NP_001020770.2
NP_001273655.1
NP_001273656.1
XP_006524276.1
XP_006524277.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025599.3 → NP_001020770.2  tripartite motif-containing protein 26

    See identical proteins and their annotated locations for NP_001020770.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) has an alternate splice site in the 5' UTR, compared to variant 3. Variants 1, 3 and 4 encode the same protein.
    Source sequence(s)
    BC037110, BQ176978, CF168373
    Consensus CDS
    CCDS37613.1
    UniProtKB/Swiss-Prot
    B8JJ55, Q8C9E9, Q8JZT7, Q99PN2, Q99PN3
    UniProtKB/TrEMBL
    Q3UFX3
    Related
    ENSMUSP00000060103.8, ENSMUST00000053434.15
    Conserved Domains (3) summary
    cd15826
    Location:320 → 544
    SPRY_PRY_TRIM15; PRY/SPRY domain in tripartite motif-binding protein 15 (TRIM15)
    cd16598
    Location:13 → 57
    RING-HC_TRIM26_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein 26 (TRIM26) and similar proteins
    cd19765
    Location:100 → 138
    Bbox2_TRIM10-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins, TRIM10, TRIM15, TRIM26, TRIM31 and similar proteins

  2. NM_001286726.1 → NP_001273655.1  tripartite motif-containing protein 26

    See identical proteins and their annotated locations for NP_001273655.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript. Variants 1, 3 and 4 encode the same protein.
    Source sequence(s)
    AK042252, BC037110, BQ176978, CF168373
    Consensus CDS
    CCDS37613.1
    UniProtKB/Swiss-Prot
    B8JJ55, Q8C9E9, Q8JZT7, Q99PN2, Q99PN3
    UniProtKB/TrEMBL
    Q3UFX3
    Conserved Domains (3) summary
    cd15826
    Location:320 → 544
    SPRY_PRY_TRIM15; PRY/SPRY domain in tripartite motif-binding protein 15 (TRIM15)
    cd16598
    Location:13 → 57
    RING-HC_TRIM26_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein 26 (TRIM26) and similar proteins
    cd19765
    Location:100 → 138
    Bbox2_TRIM10-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins, TRIM10, TRIM15, TRIM26, TRIM31 and similar proteins

  3. NM_001286727.1 → NP_001273656.1  tripartite motif-containing protein 26

    See identical proteins and their annotated locations for NP_001273656.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has an alternate splice junction in the 5' UTR, compared to variant 3. Variants 1, 3 and 4 encode the same protein.
    Source sequence(s)
    AK148247, BC037110, BQ176978, CF168373
    Consensus CDS
    CCDS37613.1
    UniProtKB/Swiss-Prot
    B8JJ55, Q8C9E9, Q8JZT7, Q99PN2, Q99PN3
    UniProtKB/TrEMBL
    Q3UFX3
    Related
    ENSMUSP00000114896.2, ENSMUST00000130367.8
    Conserved Domains (3) summary
    cd15826
    Location:320 → 544
    SPRY_PRY_TRIM15; PRY/SPRY domain in tripartite motif-binding protein 15 (TRIM15)
    cd16598
    Location:13 → 57
    RING-HC_TRIM26_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein 26 (TRIM26) and similar proteins
    cd19765
    Location:100 → 138
    Bbox2_TRIM10-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins, TRIM10, TRIM15, TRIM26, TRIM31 and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    37148016..37170290
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006524214.4 → XP_006524277.1  tripartite motif-containing protein 26 isoform X2

    See identical proteins and their annotated locations for XP_006524277.1

    UniProtKB/TrEMBL
    J3QN94, Q3UFX3
    Conserved Domains (3) summary
    cd15826
    Location:314 → 538
    SPRY_PRY_TRIM15; PRY/SPRY domain in tripartite motif-binding protein 15 (TRIM15)
    cd16598
    Location:13 → 57
    RING-HC_TRIM26_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein 26 (TRIM26) and similar proteins
    cd19765
    Location:100 → 138
    Bbox2_TRIM10-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins, TRIM10, TRIM15, TRIM26, TRIM31 and similar proteins

  2. XM_006524213.4 → XP_006524276.1  tripartite motif-containing protein 26 isoform X1

    See identical proteins and their annotated locations for XP_006524276.1

    UniProtKB/Swiss-Prot
    B8JJ55, Q8C9E9, Q8JZT7, Q99PN2, Q99PN3
    UniProtKB/TrEMBL
    Q3UFX3
    Conserved Domains (3) summary
    cd15826
    Location:320 → 544
    SPRY_PRY_TRIM15; PRY/SPRY domain in tripartite motif-binding protein 15 (TRIM15)
    cd16598
    Location:13 → 57
    RING-HC_TRIM26_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein 26 (TRIM26) and similar proteins
    cd19765
    Location:100 → 138
    Bbox2_TRIM10-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins, TRIM10, TRIM15, TRIM26, TRIM31 and similar proteins

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_030698.4: Suppressed sequence

    Description
    NM_030698.4: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99PN3.3 GenPept UniProtKB/Swiss-Prot:Q99PN3

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