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Lrrc14 leucine rich repeat containing 14 [ Mus musculus (house mouse) ]

Gene ID: 223664, updated on 5-Mar-2024

Summary

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Official Symbol
Lrrc14provided by MGI
Official Full Name
leucine rich repeat containing 14provided by MGI
Primary source
MGI:MGI:2445060
See related
Ensembl:ENSMUSG00000033728 AllianceGenome:MGI:2445060
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0014; E130306I01Rik
Summary
Predicted to enable kinase binding activity. Predicted to be involved in negative regulation of NF-kappaB transcription factor activity and negative regulation of toll-like receptor signaling pathway. Predicted to be active in cytoplasm. Is expressed in several structures, including branchial arch; genitourinary system; inner ear; lung; and nervous system. Orthologous to human LRRC14 (leucine rich repeat containing 14). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 9.8), adrenal adult (RPKM 7.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
15 D3; 15 36.28 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (76594820..76599297)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (76710615..76715097)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7385 Neighboring gene glutamic pyruvic transaminase, soluble Neighboring gene major facilitator superfamily domain containing 3 Neighboring gene RecQ protein-like 4 Neighboring gene RIKEN cDNA C030006K11 gene Neighboring gene leucine rich repeat containing 24 Neighboring gene Rho GTPase activating protein 39 Neighboring gene STARR-positive B cell enhancer mm9_chr15:76600695-76600996 Neighboring gene predicted gene, 17271

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The intergenic region between the Mouse Recql4 and Lrrc14 genes functions as an evolutionary conserved bidirectional promoter. Uwanogho DA, et al. Gene, 2010 Jan 1. PMID 19720120
  2. LRRC14 attenuates Toll-like receptor-mediated NF-κB signaling through disruption of IKK complex. Wu C, et al. Exp Cell Res, 2016 Sep 10. PMID 27426725
  3. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
  4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TLR signaling led to lower expression of LRRC14.
    Title: LRRC14 attenuates Toll-like receptor-mediated NF-κB signaling through disruption of IKK complex.
  2. we define a small core bidirectional promoter that drives expression of the mouse genes Recql4, on one strand, and Lrrc14; a novel member of the LRR gene family, on the opposite strand
    Title: The intergenic region between the Mouse Recql4 and Lrrc14 genes functions as an evolutionary conserved bidirectional promoter.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables kinase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of NF-kappaB transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of toll-like receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
leucine-rich repeat-containing protein 14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001358891.1 → NP_001345820.1  leucine-rich repeat-containing protein 14

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AC156550
    Consensus CDS
    CCDS27589.1
    UniProtKB/Swiss-Prot
    Q6A0E7, Q80WK3, Q8VC16
    Related
    ENSMUSP00000114921.2, ENSMUST00000127208.8
    Conserved Domains (3) summary
    sd00031
    Location:311 → 337
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:286 → 309
    LRR_RI; leucine-rich repeat [structural motif]
    cl39015
    Location:221 → 413
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

  2. NM_001358892.1 → NP_001345821.1  leucine-rich repeat-containing protein 14

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AC156550
    Consensus CDS
    CCDS27589.1
    UniProtKB/Swiss-Prot
    Q6A0E7, Q80WK3, Q8VC16
    Conserved Domains (3) summary
    sd00031
    Location:311 → 337
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:286 → 309
    LRR_RI; leucine-rich repeat [structural motif]
    cl39015
    Location:221 → 413
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

  3. NM_001358893.1 → NP_001345822.1  leucine-rich repeat-containing protein 14

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AC156550
    Consensus CDS
    CCDS27589.1
    UniProtKB/Swiss-Prot
    Q6A0E7, Q80WK3, Q8VC16
    Related
    ENSMUSP00000049466.9, ENSMUST00000036423.15
    Conserved Domains (3) summary
    sd00031
    Location:311 → 337
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:286 → 309
    LRR_RI; leucine-rich repeat [structural motif]
    cl39015
    Location:221 → 413
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

  4. NM_145471.3 → NP_663446.1  leucine-rich repeat-containing protein 14

    See identical proteins and their annotated locations for NP_663446.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AC156550
    Consensus CDS
    CCDS27589.1
    UniProtKB/Swiss-Prot
    Q6A0E7, Q80WK3, Q8VC16
    Related
    ENSMUSP00000115446.2, ENSMUST00000155735.2
    Conserved Domains (3) summary
    sd00031
    Location:311 → 337
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:286 → 309
    LRR_RI; leucine-rich repeat [structural motif]
    cl39015
    Location:221 → 413
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    76594820..76599297
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017316558.3 → XP_017172047.1  leucine-rich repeat-containing protein 14 isoform X1

    UniProtKB/Swiss-Prot
    Q6A0E7, Q80WK3, Q8VC16
    Related
    ENSMUSP00000121982.2, ENSMUST00000137649.8
    Conserved Domains (3) summary
    sd00031
    Location:311 → 337
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:286 → 309
    LRR_RI; leucine-rich repeat [structural motif]
    cl39015
    Location:221 → 413
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

  2. XM_006520789.5 → XP_006520852.1  leucine-rich repeat-containing protein 14 isoform X1

    See identical proteins and their annotated locations for XP_006520852.1

    UniProtKB/Swiss-Prot
    Q6A0E7, Q80WK3, Q8VC16
    Conserved Domains (3) summary
    sd00031
    Location:311 → 337
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:286 → 309
    LRR_RI; leucine-rich repeat [structural motif]
    cl39015
    Location:221 → 413
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

  3. XM_006520787.3 → XP_006520850.1  leucine-rich repeat-containing protein 14 isoform X1

    See identical proteins and their annotated locations for XP_006520850.1

    UniProtKB/Swiss-Prot
    Q6A0E7, Q80WK3, Q8VC16
    Related
    ENSMUST00000154531.8
    Conserved Domains (3) summary
    sd00031
    Location:311 → 337
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:286 → 309
    LRR_RI; leucine-rich repeat [structural motif]
    cl39015
    Location:221 → 413
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

  4. XM_030248489.2 → XP_030104349.1  leucine-rich repeat-containing protein 14 isoform X1

    UniProtKB/Swiss-Prot
    Q6A0E7, Q80WK3, Q8VC16
    Conserved Domains (3) summary
    sd00031
    Location:311 → 337
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:286 → 309
    LRR_RI; leucine-rich repeat [structural motif]
    cl39015
    Location:221 → 413
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

  5. XM_030248490.1 → XP_030104350.1  leucine-rich repeat-containing protein 14 isoform X2

    Conserved Domains (2) summary
    sd00031
    Location:116 → 142
    LRR_1; leucine-rich repeat [structural motif]
    cd21340
    Location:113 → 211
    PPP1R42; protein phosphatase 1 regulatory subunit 42

  6. XM_030248488.2 → XP_030104348.1  leucine-rich repeat-containing protein 14 isoform X1

    UniProtKB/Swiss-Prot
    Q6A0E7, Q80WK3, Q8VC16
    Conserved Domains (3) summary
    sd00031
    Location:311 → 337
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:286 → 309
    LRR_RI; leucine-rich repeat [structural motif]
    cl39015
    Location:221 → 413
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

  7. XM_030248491.1 → XP_030104351.1  leucine-rich repeat-containing protein 14 isoform X2

    Conserved Domains (2) summary
    sd00031
    Location:116 → 142
    LRR_1; leucine-rich repeat [structural motif]
    cd21340
    Location:113 → 211
    PPP1R42; protein phosphatase 1 regulatory subunit 42

  8. XM_036159346.1 → XP_036015239.1  leucine-rich repeat-containing protein 14 isoform X2

    Conserved Domains (2) summary
    sd00031
    Location:116 → 142
    LRR_1; leucine-rich repeat [structural motif]
    cd21340
    Location:113 → 211
    PPP1R42; protein phosphatase 1 regulatory subunit 42
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VC16.1 GenPept UniProtKB/Swiss-Prot:Q8VC16

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