Exoc8 exocyst complex component 8 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Exoc8provided by MGI
Official Full Name: exocyst complex component 8provided by MGI
Primary source: MGI:MGI:2142527
See related: Ensembl:ENSMUSG00000074030 AllianceGenome:MGI:2142527
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: EXO84; SEC84; Exo84p
Summary: Predicted to enable phosphatidylinositol binding activity and small GTPase binding activity. Predicted to be involved in several processes, including Golgi to plasma membrane transport; endosome organization; and extracellular matrix disassembly. Predicted to act upstream of or within exocytosis. Predicted to be located in cell leading edge and late endosome. Predicted to be part of exocyst. Is expressed in several structures, including adrenal gland; genitourinary system; lung; nervous system; and pancreas. Orthologous to human EXOC8 (exocyst complex component 8). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human all
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Genomic context

Location:: 8 E2; 8 72.82 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (125617038..125624444, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (124890299..124897705, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that TBK1 directly interacts with Exo84 through the coiled-coil domain of TBK1 and helical domain of Exo84, and knockdown of TBK1 blocked insulin-stimulated glucose uptake and GLUT4 translocation.
Title: Phosphorylation of the exocyst protein Exo84 by TBK1 promotes insulin-stimulated GLUT4 trafficking.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI414418 (e-PCR)
- UniSTS:159836

RH125106 (e-PCR)
- UniSTS:161928

NoName (e-PCR)
- UniSTS:224697

NoName (e-PCR)
- UniSTS:236028

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables phosphatidylinositol binding	ISO Inferred from Sequence Orthology more info
enables small GTPase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Golgi to plasma membrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in endosome organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within exocytosis	ISO Inferred from Sequence Orthology more info
involved_in extracellular matrix disassembly	ISO Inferred from Sequence Orthology more info
involved_in membrane fission	NAS Non-traceable Author Statement more info	PubMed
involved_in mitotic cytokinesis	NAS Non-traceable Author Statement more info	PubMed
involved_in protein localization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info
involved_in vesicle docking involved in exocytosis	NAS Non-traceable Author Statement more info	PubMed
involved_in vesicle tethering involved in exocytosis	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cell leading edge	ISO Inferred from Sequence Orthology more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of exocyst	IBA Inferred from Biological aspect of Ancestor more info
part_of exocyst	ISO Inferred from Sequence Orthology more info
part_of exocyst	NAS Non-traceable Author Statement more info	PubMed
located_in late endosome	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: exocyst complex component 8

Names: exocyst complex 84 kDa subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_198103.2 → NP_932771.1 exocyst complex component 8

See identical proteins and their annotated locations for NP_932771.1

Status: VALIDATED

Source sequence(s)

AC151736, AK054047, BC057052, BC094378

Consensus CDS

CCDS22777.1

UniProtKB/Swiss-Prot

Q6PGF7

Related

ENSMUSP00000095915.3, ENSMUST00000098312.4

Conserved Domains (4) summary

cd01226
Location:167 → 279

PH_RalBD_exo84; Exocyst complex 84-kDa subunit Ral-binding domain/Pleckstrin Homology (PH) domain

pfam00169
Location:174 → 273

PH; PH domain

pfam08700
Location:13 → 97

Vps51; Vps51/Vps67

pfam16528
Location:326 → 531

Exo84_C; Exocyst component 84 C-terminal