Table 8.

Recommended Additional Surveillance for Symptomatic Individuals with AIP-FIPA

System/ConcernEvaluationFrequency
History of pituitary
adenoma
  • Clinical assessment
  • Serum IGF-1, spot growth hormone, prolactin, estradiol/testosterone, LH, FSH, TSH, free T4, morning cortisol
  • If necessary dynamic testing (e.g., glucose tolerance test, insulin tolerance test) to evaluate for hormone excess or deficiency
Annually
Pituitary MRIFrequency depends on clinical status, previous extent of tumor, & treatment modality.
Osteoporosis in those
w/hypogonadism 		DXA evalPer established guidelines
Complications of
acromegaly 		Monitor for diabetes mellitus, hypertension, hypogonadism, & osteoarthritis.Per established guidelines
Colonoscopy
  • At age 40 yrs
  • Repeat every 3 to 10 yrs depending on # of colorectal lesions on initial colonoscopy & IGF-1 levels. 1

From: AIP Familial Isolated Pituitary Adenomas

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