4FMO


Conserved Protein Domain Family
Mlh1_C

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pfam16413: Mlh1_C 
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DNA mismatch repair protein Mlh1 C-terminus
This is the C-terminal domain of DNA mismatch repair protein Mlh1, these proteins belong to the MutL family. This domain forms part of the endonuclease active site.
Statistics
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PSSM-Id: 465109
Aligned: 164 rows
Threshold Bit Score: 133.818
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4FMO_A         29 NLTSIKKLREKVDDSIH-RELTDIFANLNYVGVVDEerRLAAIQHDLKLFLIDYGSVCYELFYQIGLTDF-----ANFGK 102  Saccharomyces...
Q57TS9        623 LLTSVSTIVSNIRAGTS-QTAQSLFQNLAYVGVLKG--HLFFAQSGTTLYVVDSLRLVRHVVYQRIFLRWatpslSAVPQ 699  Trypanosoma b...
XP_001016280  505 RIQVQQQLLSLRNQDIH-DTTSSFFKNLTYVGCISSnhFLA--QFRDDLYLINSIPLCQEIFKFEILRNF-----GQIKP 576 
Q8IIJ0        710 EISSIKKLKMICEEKEK-KELTECLKNSIYVGPVDN--MHSLIQYKEKLLLIKMPLIIKEVTYQSILNRL-----GKIPP 781  Plasmodium fa...
CAQ39952      560 dISSIRKLKRICEEKEK-KELTECLKNSIYVGAVDN--LHSLIQYKDKLLMIKMPLIIKEITYQSILNRI-----GRIPP 631 
Q5CRJ3        548 TEIEIMNDNTEASKMEYlKSLTKNIINGIYIGQIKS--SWSIIQAKNQILLINIEQMSKIALKQSLICRL-----GYIPL 620  Cryptosporidi...
1_pfamImport    1 EFESLEFLRRQIVNESS-LSLRNLFKTCIFVGSIDP--QTILVQFGTSLYQIDFAAVLREFFYQISIFSF-----GNYGS 72  
Q9XU10        501 HFESIEVLRKEIIANSS-QSLREMFKTSTFVGSINV--KQVLIQFGTSLYHLDFSTVLREFFYQISVFSF-----GNYGS 572  Caenorhabditi...
EGT60154      500 DFESLDIIRRQIVSTTS-LSLREMIKTSTFVGSIDC--EQVLFQFGTSLYIMNFKAVLREFFYQISIFSF-----GNFGS 571 
CAP33641      500 EFESLEILRHQIASSAS-LSLRELIKTSTFVGSIDP--ETVLIQFGTSLYMLKFSEILREFFYQISILSF-----GNYGS 571 
4FMO_A        103 INLqstnvsDD-IVLYNLLse----fD----ELNDDA-----------------SKEK----IISKIWDMSSMLNEY--- 149  Saccharomyces...
Q57TS9        700 LSF------EEpIHLSDLL-------S----FALQNDvqlppsqk-radggpgsLLSR----LGRRLCNWRYMLQDY--- 754  Trypanosoma b...
XP_001016280  577 VEL------NQaIGLKDILeyfllnfD-----EIPNEkkef----------hlsNMDT----YIEQFGLLSDFLRDS--- 628 
Q8IIJ0        782 FEF------DPpIPLYDLL-------L----VAVNNSysgfyenpnyankniekVCNE----LEQIFYTYNEMYSDY--- 837  Plasmodium fa...
CAQ39952      632 FKF------DPpIPLYDLL-------L----VAMNNSqsgyfenpdyvtknierICNE----LEQVFYSYEEMYADY--- 687 
Q5CRJ3        621 LKL------NPpVSLGELS-------------LFGTEsvk-----------nykLNENdqiqLKDFINSQAYLYFDIlkv 670  Cryptosporidi...
1_pfamImport   73 YRLe-----EDpPAIQELL-------EllgeLSASDEnyaafevf---------agaekrkeAEAMLAEHAELLNDY--- 128 
Q9XU10        573 YRLd-----EEpPAIIEIL-------EllgeLSTREPnyaafevf---------anvenrfaAEKLLAEHADLLHDY--- 628  Caenorhabditi...
EGT60154      572 YRLe-----QEpPSILEML-------EligeLSENDErykgfgvf---------kqeekrveAENLLGEQAELLHDY--- 627 
CAP33641      572 YRLe-----EEtPLIIDML-------EligeLSETDEnykafsif---------rdpttreeAEFLLGEHVELLYDY--- 627 
4FMO_A        150 YSIELvnd--glD-NDlksVKLKSLPLLLKG-Y--IPSLVKLPFFIYRLGKEVDWE--DEQECLDGILREIA-LLYIpdm 220  Saccharomyces...
Q57TS9        755 FAVEI-------S-AD---GHLIALPLSMGTsW--PPPLRAVPLFIWRLAAEVPYNa-GEIECFTAIARHIAeTLYGv-- 818  Trypanosoma b...
XP_001016280  629 VGIVI---------KD---QKLLAFPNLFNL-FenDNNFKDISYILLRIITKVNFS--EILQSGMGLANELS-FYFAw-- 690 
Q8IIJ0        838 FSIII---------ED---GCIVTFPACCGE-Y--FPGQEFLPFLFLRLATQIDYS--KEINCINGICYLLA-NFYSkit 899  Plasmodium fa...
CAQ39952      688 FSIII---------ED---GCVCTFPACCGE-Y--FPGQEFLPLLFLRLATQVDYE--NELNCINGICYLIA-NFYSkvt 749 
Q5CRJ3        671 LGIDF-------DsSN---NSFSTLPLFFGN-F--VPNIDFLPELFEHVIFA-CWNfhIAHACKQKLLNTGSaQILNph- 735  Cryptosporidi...
1_pfamImport  129 FAIKLewsdenlGeKK---LILTGIPSLVHY-Y--VPQLEKLPFLIAELVLEVDYD--DEKSCFESICRALG-RLFS--- 196 
Q9XU10        629 FAIKLdq----lEnGR---LHITEIPSLVHY-F--VPQLEKLPFLIATLVLNVDYD--DEQNTFRTICRAIG-DLFT--- 692  Caenorhabditi...
EGT60154      628 FAIKMewfgeeeDqRR---LHLTEIPSLVHY-Y--VPQLEKLPFLIAALILDVDYD--DEQKCFESVSRAIG-DLFT--- 695 
CAP33641      628 FAIKMewmclegEkRR---LHITEIPSLVHH-Y--VPQLEKLPFLVASLILDVEYD--DEQKCFQSICRAIA-ELFT--- 695 
4FMO_A        221 vp------------------------------------------kvdtSD---ASLsEDEKAQFINRKEHISSLLE---- 251  Saccharomyces...
Q57TS9        819 ------------------------------------------------QLhssWLPnVIKDGIRQDDVPPFCDAIR---- 846  Trypanosoma b...
XP_001016280  691 ------------------------------------------------QLeksFKNqLQRQHFQETQKQKWDDFFE---- 718 
Q8IIJ0        900 llndkewtyqddllmiqekekeiqmllnksnkhinnsnhhnqhydetnLDyilGDEsVVDINKHLSVSRNINLVFE---- 975  Plasmodium fa...
CAQ39952      750 llddkewtfqnellmlkekeiq-mlqgqattdgsgeasplanddqtyhFEnilGDEtVIDVNRHLAASKNINLVFE---- 824 
Q5CRJ3        736 -----------------------------------------------fNEennCLSdKISEDYIIKLYELFIELIEilvd 768  Cryptosporidi...
1_pfamImport  197 -------------------------------------------------LhtgFVTaDKLVSKFST--MRWKPMVK---- 221 
Q9XU10        693 -------------------------------------------------LdtnFITlDKKISAFSA--TPWKTLIK---- 717  Caenorhabditi...
EGT60154      696 -------------------------------------------------LhkhFVTdEKKVSRFST--MYWKPLIK---- 720 
CAP33641      696 -------------------------------------------------LhspFITaEKKVSAFCG--THWKPLIK---- 720 
4FMO_A        252 ---------HVLFPCI---KRRFLAPRHILK--DVVEIANLPDLYKVFERC 288  Saccharomyces cerevisiae S288C
Q57TS9        847 ---------FGLLPCAt-nSTFFVPPCDALVdgTVQAVVSVDELYKVFERC 887  Trypanosoma brucei
XP_001016280  719 ---------QKMLPMI---KKKLSLPKLDISe-FTVKLFKQEDAYKIFERC 756 
Q8IIJ0        976 ---------KYFFPMIq-lNNIMKIPTTFSNngYIIELTSLNQLYKIFERC 1016 Plasmodium falciparum 3D7
CAQ39952      825 ---------KYFFPMIq-lNTIMRVPRTFSTngYIIELTSLNQLYKIFERC 865 
Q5CRJ3        769 yylfgiednELLFQAIrnnNNLILVEDQISQn--IIELSSLEKLYRVFERC 817  Cryptosporidium parvum
1_pfamImport  222 ---------HILFPLV---KRKLIPPESFKQqnVIKQLADAHDLYKVFERC 260 
Q9XU10        718 ---------EVLMPLV---KRKFIPPEHFKQagVIRQLADSHDLYKVFERC 756  Caenorhabditis elegans
EGT60154      721 ---------QILMPLV---KRKFIPPEHFKEkqIIKQLADSHDLYKVFERC 759 
CAP33641      721 ---------QVLMPLV---KRKFIPPEHFKSadIFVQLADSHDLYKVFERC 759 
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