Conserved Protein Domain Family
Cyclin_D1_bind

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pfam12014: Cyclin_D1_bind 
Cyclin D1 binding domain
Ubiquitin-dependent proteolysis of cyclin D1 is associated with normal and tumour cell proliferation and survival. The best characterized member of this family is the SCF FBXO31 (Skp1-Cul1-Rbx1-FBXO31) ubiquitin ligase complex mediates genotoxic stress-induced cyclin D1 degradation. FBXO31 possesses a unique substrate-binding beta barrel domain, whereas cyclin D1 binds to FBXO31 by tucking its free C-terminal carboxylate tail into an open cavity of the C-terminal FBXO31 beta-barrel. Biophysical and functional studies demonstrated that SCFFBXO31 is capable of recruiting and ubiquitinating cyclin D1 in a phosphorylation-independent manner.
Statistics
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PSSM-Id: 463431
Aligned: 97 rows
Threshold Bit Score: 99.989
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
OCT84536            281 YRRIYhP----PNrpddLLNP--GFFKGTYGSHGLEIVMFSF-------------------------------------- 316
ELR09885            324 YATLD-PalytPT----YTRPfrGIWVGDYSAHGCEFILLHQpdddepfdesaivkrs--------desqeqflarkkda 390
EDO02100            330 WSTLD-FglytPT----EDKPfrGIFVGDYSGHGCEYLLLDQrdgfqkndepnilerk--------detpevweakkrha 396
Q5B2M1              301 YSTLD-PslytPT----KEKPyqGIWVGDYSAHGCEFLLFLQrdkesdedda---------------------rdprndd 354 Aspergil...
CAP94818            282 YSTLN-PalytPT----AEKPyqGIWVGDYSAHGCEFLLVLQketeaeahsdek----------------qskitdaqed 340
GAD93436            325 YATLE-PelyiPT----REKPyqGIWVGDYSDHGCEFLLFLQrgkgsvsssssieqaggeghthaaenevaeegeiqgdg 399
KJF60847            305 FGTLR-PdlytPT----KDKPyqGIWIGDYSGHGSEYLLILQqdydpastghsaagatven--aasssqatssqnvepgn 377
EEH04107            330 FASLQ-PelytPT----PEKPyqGIWVGDYSGHGSEFLLVLQrddpfehslgtkqqgaeg-----dssgsiysslagsss 399
WGS:ABKI:PADG_01292 279 FATLQ-PelytPT----PEKPyrGVWVGDYSGHGSEFLLVMQrdgpvidflddehpdted----kssistssstegpsps 349
EGZ69627            480 YSTLD-EklytPT----PEKPyrGIFVGHYGPHGCEFILMHQpdddpniqdaeierre--------netdeefqkrtqes 546
OCT84536            317 --HGTIAKATKITGDPNVPAGQQTLEVDltrpvqlpDv------EHLRNFDE-ISRLILdvqsqiqreqrqtgneeddgk 387
ELR09885            391 qiYRGRLEAIKLTGDPNIPRGEYTFIAE--------DigddglvRIAKEDQFkGARIVK--------------------- 441
EDO02100            397 kiYKGSLCAIKLTGDPNIPRGQISWIAD--------Disdn-glvRHGEQAWpGARIVK--------------------- 446
Q5B2M1              355 iiQKGSLEAVKLTGDPNVPRGQFSFVSD--------DigpggtvRIATEALFqGARVVR--------------------- 405 Aspergil...
CAP94818            341 igQRGSLQAVKLTGDPNVPRGQFSFVAE--------DigsrgliSVEMEEPFvGARIVR--------------------- 391
GAD93436            400 liQKGSLEAIKLTGDPNVPRGEISWISE--------DigpgglvRIAEEDPFrGARMVR--------------------- 450
KJF60847            378 vpYRG-LKAIKLTGDPNVPRGEITFKAD--------DigpngtiRIADEEMFrGARVVN--------------------- 427
EEH04107            400 qtPRGRLEAIKLTGDPNVPRGQITFFAE--------DigpegliRIADEDLFkGARVVR--------------------- 450
WGS:ABKI:PADG_01292 350 spPRQRLEAVKLTGDTNVPRGEISFLSE--------DigaggliRVADEDLFkGARVVR--------------------- 400
EGZ69627            547 kiYKGGLAGIKLTGDPNVPRGEYTFVAK--------DigeegfvKVADEEEFrGARVVK--------------------- 597
OCT84536            388 gagpdraehsqqpapvhrpakedvngvdnaddreqkppnvqsfvlpagvmarneeyprsckmcFYGtgLIAGHGFSSPER 467
ELR09885            442 ---------------------------------------------------------------SKG--QLANRNFMNPEY 456
EDO02100            447 ---------------------------------------------------------------SRG--QIANQGYRNSKF 461
Q5B2M1              406 ---------------------------------------------------------------SRG--HVAGLGFRDDTF 420 Aspergil...
CAP94818            392 ---------------------------------------------------------------CRG--HVAGLGFRDDTY 406
GAD93436            451 ---------------------------------------------------------------SRG--HVAHLGFRDDKF 465
KJF60847            428 ---------------------------------------------------------------SWG--HIAATNFARDTY 442
EEH04107            451 ---------------------------------------------------------------SQG--HIASTNFRDDKF 465
WGS:ABKI:PADG_01292 401 ---------------------------------------------------------------AQG--HIAWTNFRDDKF 415
EGZ69627            598 ---------------------------------------------------------------AKG--HVAEHNFRDDDW 612
OCT84536            468 TPGLFILFDEDRFGFIWLELKSFSLYSRM-RDR 499
ELR09885            457 FESQLILISPNKIAHYWKSLGIICFHERVkLDD 489
EDO02100            462 IETELIMISHDVLAQHWLPFGHISFFHRVnIDD 494
Q5B2M1              421 ITSQLILVSPDCVAHYWESMGHITYYRRLdIDA 453 Aspergillus nidulans
CAP94818            407 IDSQLILISPDHMAHYWKEMGHVSYFRRVdIDA 439
GAD93436            466 LSSQLILISRDCIAHYWEDLDHISYFYRVdIDE 498
KJF60847            443 IPSQLILISNDCIAHYWTELGHISYYRRIdIDQ 475
EEH04107            466 IPAQLFLLSYDCMALFWEELKHVSYYRRVdIDG 498
WGS:ABKI:PADG_01292 416 IPAQLFLISNDCMALFWEELKHISYYRRVdVDE 448
EGZ69627            613 IDCDLFLASHNTLALHWHRWDMTSVFERVdIDK 645
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