Conserved Protein Domain Family
Dickkopf_N
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pfam04706: Dickkopf_N 
Dickkopf N-terminal cysteine-rich region
Dickkopf proteins are a class of Wnt antagonists. They possess two conserved cysteine-rich regions. This family represents the N-terminal one. The C-terminal region has been found to share significant sequence similarity to the colipase fold, pfam01114, pfam02740.
Links
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Statistics
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PSSM-Id: 461401
Aligned: 45 rows
Threshold Bit Score: 31.578
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_007478408 251 LCVDDKDCGLEEYCDAGSRGGgggagsigvqICLPCRKRRRRCQRSVMCCPGNYCSNGICV 311
EDO42240       1 -CRKDKHCGQGKYCHRHYG------------TCHDVKPLGEHCRRDHVCAAGMECVFGKCR 48 
EFX74373      95 KCMEDKQCGKGRFCDLHYG------------VCRTEKSPGFACRRDRMCGKGLACMFGRCQ 143
XP_017548588  99 ACEHDRACGKGFSCDRHFG------------LCVPLRQEGKYCRRDAQCVRGLSCMFGKCI 147
EGC31774     144 PCSSDRECAYGNFCNITSEPDqd-------nTCLPVLASSSVCTRDAQCPYNQICVKMAFD 197
Q54KK1       152 ECYMDEDCPSGNFCYWGSNKN----------LCKPLNKIGSNCTYGNDFTLGSICRNNKCI 202 Dictyostelium discoideum AX4
XP_003294997 121 ICYSDNNCPYNYYCFLVGVSSsgnn---gdgVCVP--KTSRNCESSNECSTGYTCIYGICV 176
XP_014344262 126 GCLVDEDCDVGFYCDSALFVS----------ECRGCKTKAMECAGDGECCSGYLCVWGHCA 176
XP_003224232 146 ECIIDEDCVNGKYCEFSGLEY----------KCRDCKIEHKRCSRDVECCGHQLCVWGECM 196
PNI79262     118 ECIIDEDCGPSKYCQFASFQY----------TCQPCRGQRMLCTRDSECCGDQLCVWGHCT 168
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