Conserved Protein Domain Family
RING-H2_Rapsyn
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cd16478: RING-H2_Rapsyn 
RING finger, H2 subclass, found in 43 kDa receptor-associated protein of the synapse (Rapsyn) and similar proteins
Rapsyn, also known as acetylcholine receptor (AChR)-associated 43 kDa protein or RING finger protein 205 (RNF205), is a 43 kDa postsynaptic protein that plays an essential role in the clustering and maintenance of AChR in the postsynaptic membrane of the motor endplate. AChRs enable the transport of rapsyn from the Golgi complex to the plasma membrane through a molecule-specific interaction. Rapsyn also mediates subsynaptic anchoring of protein kinase A (PKA) type I in close proximity to the postsynaptic membrane, which is essential for synapse maintenance. Its mutations in humans cause endplate AChR deficiency and myasthenic syndrome. Rapsyn contains an N-terminal myristoylation signal required for membrane association, seven tetratricopeptide repeats (TPRs) that subserve rapsyn self-association, a coiled-coil domain responsible for the binding of determinants within the long cytoplasmic loop of each AChR subunit, a C3H2C3-type RING-H2 finger that binds to the cytoplasmic domain of beta-dystroglycan and to S-NRAP and links rapsyn to the subsynaptic cytoskeleton, and a serine phosphorylation site.
Links
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Statistics
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PSSM-Id: 438141
Aligned: 11 rows
Threshold Bit Score: 70.5668
Created: 2-May-2013
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H H C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structures of other RING-H2 fingers with bound zinc
  • Comment:C3H2C3-type RING-H2 finger consensus motif: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-H-X2-C-X(4-48)-C-X2-C, where X is any amino acid and the number of X residues varies in different fingers
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1           #  #               # #  #  #                 #  #  
Q13702       360 ELYCGLCGEsIGEKNSRLQALPCSHIFHLRCLQnn---------gtRSCPNCRR 404 human
O42393       360 ELYCGMCGEsIGEKNNQLQALPCSHFFHLKCLQtn---------gtRGCPNCRR 404 chicken
NP_001005667 360 ELYCGMCGEsIGEKNCQLQALPCSHVFHLRCLQtn---------gtRGCPNCRR 404 western clawed frog
NP_840090    360 ELYCGMCGEsIGEKNQQLQALPCSHIFHLKCLQtn---------gtKGCPKCHR 404 zebrafish
NP_001071936 407 ELFCGICAEpMAEKNEQLEALPCSHFFHLKCVSnnda------lemRMCPSCQK 454 Ciona intestinalis
NP_651928    452 GLNCGACGElLGLRPENLEALPCAHILHARCAYeilrrr--eknapRSCPACNK 503 fruit fly
XP_005987008 314 ELYCGMCGEsIGDKNHQLQALPCSHLFHLKCLQtn---------gtRGCPNCRR 358 coelacanth
XP_007883141 358 ELYCGMCGEsIGDKNAPLQALPCSHIFHLKCLQkn---------gtNGCPNCKR 402 elephant shark
XP_006814328 118 ALSCGVCNEvISEKPESLESLQCSHLFHASCLEeyta------gdsRGCPDCRR 165 Saccoglossus kowalevskii
Q09485       371 QLFCNFCGQrYGLKDESLQALRCSHIFHEKCLHtyll-----qrtdQTCPKCRC 419 Caenorhabditis elegans
XP_013095227  36 DLFCGVCGEvVGQVPERLEPLTCGHFVHARCAVhlarstmgrsgkrRPCPACRK 89  Biomphalaria glabrata

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