Conserved Protein Domain Family
Upf2
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pfam04050: Upf2 (this model, PSSM-Id:367784 is obsolete and has been replaced by 461146)
Up-frameshift suppressor 2
Transcripts harbouring premature signals for translation termination are recognized and rapidly degraded by eukaryotic cells through a pathway known as nonsense-mediated mRNA decay. In Saccharomyces cerevisiae, three trans-acting factors (Upf1 to Upf3) are required for nonsense-mediated mRNA decay.
Links
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Statistics
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PSSM-Id: 367784
Aligned: 122 rows
Threshold Bit Score: 64.7143
Created: 5-May-2019
Updated: 18-Jul-2019
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
GAC73050 1038 EE-----LAARR-------------EADDEFDRELARMMVESSapgtataqssagaST---SQRPHQ-----FfsRAALP 1091 Moesziomyces anta...
EDV25348  909 GEne-dvTILSGglka------mpcEEDDDFQKEYEKALADDL-------------LT---RRQHGPkv-psL--DAPLP 962  Trichoplax adhaerens
EEH57589 1130 NAansapVELAPeervkrvvpkvskEVEADFDREMSKFLGPGI----------------------VAaktpvVasYGQTP 1187 Micromonas pusill...
CAP25938  940 egeqefedsdeerqrglsmsnavtkEEDDDFQRELDRMMGEGF------------------RQSAAPaaavqY--DVTLP 999  Caenorhabditis br...
EGT55990  940 dgdldeedsdeeqqklyiatntvtkEEDEDFQRELDRMMGEGF------------------RQSGAPvtapqY--DVTLP 999  Caenorhabditis br...
ESS34235 1222 DEaedlrDYVREhv---------qkEEELRFGADFAQMMLASLn------------EAktlRRPTSS--------EMKIP 1272 Toxoplasma gondii...
CBZ55880 1285 AEdedlrDYVREhvqkeeasrpqriYTELQFDADFAQMMLASLn------------DAktlRRPTGS--------EMKIP 1344 Neospora caninum ...
CBN74240 1458 DDgedeqEVVLNgwgvgverteedgEAEDEFEALLSKTMSESV------------------EKTKIArattqVmgHMAVP 1519 Ectocarpus silicu...
EEC43505 1247 EEeeefde-----------eaymrqLEEEAFERELRRVTIEAL-------------EK---GKNTSR------------- 1286 Phaeodactylum tri...
EED93559  935 DEeesdnEEEDGideaaaeaayirqLQDEAFESELRKLTMDAL-------------ER---GKMSARtgaggKv-SSQMP 997  Thalassiosira pse...

GAC73050 1092 SGGAsygpahs---hahahaSGSSlseiGlPIKKKAAEQANGgveaEagSHMKFSLLSK-KGSKQVTHEVYVPATASIAI 1167 Moesziomyces anta...
EDV25348  963 FNRIc---------------NFSV---------SFISNIYFNvgenLqtDDINFVLLTR-KSNKLQYKEVNIPVSDAVAA 1017 Trichoplax adhaerens
EEH57589 1188 ------------------------------STVARAAPTTRGpgmnGpgPTVAFKMLVK-KDGKPASRTLDVPAEAEFVA 1236 Micromonas pusill...
CAP25938 1000 AAAKnrfsrni--kfaedtkARSSpsrsSeMDFDDEPSSSTGvaasGrqKQGRVTLMVRgKANKPALKTVNI-DDGELQR 1076 Caenorhabditis br...
EGT55990 1000 AAVKnrfnrni--kfaentkVESSsnsrLyEVNDDDEPSTSHtsasGrpKQSRVTLMVRgKANKPSLKTVNI-DDDELQK 1076 Caenorhabditis br...
ESS34235 1273 ANVLketesls--eaprpssEEASsrevLtSGDADDGDLDPDgplpRptTAMRLVLRRPdKRNRFVVRPLAVPTDASLAE 1350 Toxoplasma gondii...
CBZ55880 1345 PNVLkeaaespsegasgkrpQGEEsptaSdRLAADEGELDFEgplaRptTVMRLVLRRPdKRNRFVVRPLAVPTDAVLAE 1424 Neospora caninum ...
CBN74240 1520 r-----------------------------VLKNTNVRTATHqaplTggSGVAFKLLKRgNKGKMEAQEVVVPESTSLAA 1570 Ectocarpus silicu...
EEC43505 1287 KLVAenmv---------sgsQTFKkkptDlSKPVGASSAVAPtfglAgtPGITFQLLKKgNKGKVEAKEIVVPSDTNFAK 1357 Phaeodactylum tri...
EED93559  998 AA-------------------PQFakkpGvAEPKQESEVDPTtnpfGgsEGMSFKLLKKgNKGKMEEKQFLVPTSTNLAR 1058 Thalassiosira pse...

GAC73050 1168 NTRTKQLK---EEAERRQLKQQILA 1189 Moesziomyces antarcticus T-34
EDV25348 1018 NIREKIAQ---EKADKEEMKRLVLS 1039 Trichoplax adhaerens
EEH57589 1237 RVKEQAEA---EQRERAELKRLVLM 1258 Micromonas pusilla CCMP1545
CAP25938 1077 RWKEEKAR---EEEERADMKRLTLG 1098 Caenorhabditis briggsae
EGT55990 1077 RWKEEKAR---EEEERAEVKRLTLG 1098 Caenorhabditis brenneri
ESS34235 1351 HSRRKDQQarqEKAERADLKKFVIE 1375 Toxoplasma gondii VEG
CBZ55880 1425 SSRRKDQQaqqEEAERANLKRFVMD 1449 Neospora caninum Liverpool
CBN74240 1571 QVNRNEEA---SREESFIIKARVLA 1592 Ectocarpus siliculosus
EEC43505 1358 VASKQDDA---AARERNFIKQRVLQ 1379 Phaeodactylum tricornutum CCAP 1055/1
EED93559 1059 RATKVDDE---AVKEKEMIKARVLQ 1080 Thalassiosira pseudonana CCMP1335
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