Conserved Protein Domain Family
Upf2

?
pfam04050: Upf2 
Up-frameshift suppressor 2
Transcripts harbouring premature signals for translation termination are recognized and rapidly degraded by eukaryotic cells through a pathway known as nonsense-mediated mRNA decay. In Saccharomyces cerevisiae, three trans-acting factors (Upf1 to Upf3) are required for nonsense-mediated mRNA decay.
Statistics
?
PSSM-Id: 461146
Aligned: 108 rows
Threshold Bit Score: 58.5207
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
GAC73050     1038 EE-----LAARR-------------EADDEFDRELARMMVESSapgtataqssagaST---SQRPHQ-----FfsRAALP 1091
ESS34235     1222 DEaedlrDYVREhv---------qkEEELRFGADFAQMMLASLn------------EAktlRRPTSS--------EMKIP 1272
CBN74240     1458 DDgedeqEVVLNgwgvgverteedgEAEDEFEALLSKTMSESV------------------EKTKIArattqVmgHMAVP 1519
EED93559      935 DEeesdnEEEDGideaaaeaayirqLQDEAFESELRKLTMDAL-------------ER---GKMSARtgaggKv-SSQMP 997 
EEC43505     1247 EEeeefde-----------eaymrqLEEEAFERELRRVTIEAL-------------EK---GKNTSR------------- 1286
EGV95423      357 DEenaevMIKGGglkh------vpcVEDEDFIQALDKMMLENL-------------QQ---RSGESVkv-hqL--DVAIP 411 
XP_015207795 1082 DEentevTIMGGglkh------vacAEDEEFIQALDKMMLENL-------------QQ---RSGESVkv-hqL--DVAIP 1136
ESN94504      981 DEdddnhVTLDVgpkf------ikcQEDDDFLSALDKMMSDSV-------------QA---RQQEIVki-pvV--EIAVP 1035
EDV25348      909 GEne-dvTILSGglka------mpcEEDDDFQKEYEKALADDL-------------LT---RRQHGPkv-psL--DAPLP 962 
CAF92436     1116 DEennevTIRGGglkh------vacAEDEDFIQALDKMMLENLq------------Q----RSGETVkv-hqL--DVAIP 1170 spotted green...
GAC73050     1092 SGGAsygpah-shahahASGSSlseiGlPIKKKAAEQANGgveaEagSHMKFSLLSK-KGSKQVTHEVYVPATASIAINT 1169
ESS34235     1273 ANVLketeslseaprpsSEEASsrevLtSGDADDGDLDPDgplpRptTAMRLVLRRPdKRNRFVVRPLAVPTDASLAEHS 1352
CBN74240     1520 r---------------------------VLKNTNVRTATHqaplTggSGVAFKLLKRgNKGKMEAQEVVVPESTSLAAQV 1572
EED93559      998 AA-----------------PQFakkpGvAEPKQESEVDPTtnpfGgsEGMSFKLLKKgNKGKMEEKQFLVPTSTNLARRA 1060
EEC43505     1287 KLVAenm-------vsgSQTFKkkptDlSKPVGASSAVAPtfglAgtPGITFQLLKKgNKGKVEAKEIVVPSDTNFAKVA 1359
EGV95423      412 LHLK-------------SQLRK-----------GPPLGGGegetEsaDTMPFVMLTR-KGNKQQFKILNVPMSSQLAANH 466 
XP_015207795 1137 LQLK-------------SQLKK----------GPPPVVGGegdtEmvDTMQFVMLTR-KGNKQQFKILNVPLSSHLAANH 1192
ESN94504     1036 MAQK-------------NNLNGk---IiGPNSKSQTYVTDeeedEkvSLIPFTVLTR-KGNKPQLSTLSIPLSENFASKF 1098
EDV25348      963 FNRI-------------CNFSV---------SFISNIYFNvgenLqtDDINFVLLTR-KSNKLQYKEVNIPVSDAVAANI 1019
CAF92436     1171 LQLK-------------SQLRK---------GGSAQPCISegdaDvsNTMQFVMLTR-KGNKQQYKILNVPLSSHLAANH 1227 spotted green...
GAC73050     1170 RTKQLK---EEAERRQLKQQILA 1189
ESS34235     1353 RRKDQQarqEKAERADLKKFVIE 1375
CBN74240     1573 NRNEEA---SREESFIIKARVLA 1592
EED93559     1061 TKVDDE---AVKEKEMIKARVLQ 1080
EEC43505     1360 SKQDDA---AARERNFIKQRVLQ 1379
EGV95423      467 WNQQQA---EQEERMRMKKLTLD 486 
XP_015207795 1193 FNQQQA---EQEERMRMKKLTLD 1212
ESN94504     1099 KEQIKH---DQEEKERMKRMVLE 1118
EDV25348     1020 REKIAQ---EKADKEEMKRLVLS 1039
CAF92436     1228 FNQQQA---EQEERMRMKKLTLD 1247 spotted green pufferfish
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap