CDD Conserved Protein Domain Family: RING-H2

cd16478: RING-H2_Rapsyn (this model, PSSM-Id:319392 is obsolete and has been replaced by 438141)

RING finger, H2 subclass, found in 43 kDa receptor-associated protein of the synapse (Rapsyn) and similar proteins

Rapsyn, also known as acetylcholine receptor-associated 43 kDa protein or RING finger protein 205 (RNF205), is a 43 kDa postsynaptic protein that plays an essential role in the clustering and maintenance of acetylcholine receptor (AChR) in the postsynaptic membrane of the motor endplate (EP). AChRs enable the transport of rapsyn from the Golgi complex to the plasma membrane through a molecule-specific interaction. Rapsyn also mediates subsynaptic anchoring of protein kinase A (PKA) type I in close proximity to the postsynaptic membrane, which is essential for synapse maintenance. Its mutations in humans cause endplate acetylcholine-receptor deficiency and myasthenic syndrome. Rapsyn contains an N-terminal myristoylation signal required for membrane association, seven tetratricopeptide repeats (TPRs) that subserve rapsyn self-association, a coiled-coil domain responsible for the binding of determinants within the long cytoplasmic loop of each AChR subunit, a C3H2C3-type RING-H2 finger that binds to the cytoplasmic domain of beta-dystroglycan and to S-NRAP and links rapsyn to the subsynaptic cytoskeleton, and a serine phosphorylation site.

Feature 1 # # # # # # # # Q13702 360 ELYCGLCGEsIGEKNSRLQALPCSHIFHLRCLQnn-------gtRSCPNCRR 404 human O42393 360 ELYCGMCGEsIGEKNNQLQALPCSHFFHLKCLQtn-------gtRGCPNCRR 404 chicken NP_001005667 360 ELYCGMCGEsIGEKNCQLQALPCSHVFHLRCLQtn-------gtRGCPNCRR 404 western clawed frog NP_840090 360 ELYCGMCGEsIGEKNQQLQALPCSHIFHLKCLQtn-------gtKGCPKCHR 404 zebrafish NP_001071936 407 ELFCGICAEpMAEKNEQLEALPCSHFFHLKCVSnnda----lemRMCPSCQK 454 Ciona intestinalis XP_002587259 361 ELYCGACGDtYGEKPDRIEALPCSHIFHSRCVEttl-----qktTGCPDCRR 407 Florida lancelet NP_651928 452 GLNCGACGElLGLRPENLEALPCAHILHARCAYeilrrreknapRSCPACNK 503 fruit fly XP_005987008 314 ELYCGMCGEsIGDKNHQLQALPCSHLFHLKCLQtn-------gtRGCPNCRR 358 coelacanth XP_007883141 358 ELYCGMCGEsIGDKNAPLQALPCSHIFHLKCLQkn-------gtNGCPNCKR 402 elephant shark XP_003729649 361 ELYCGVCHEvMGNRENSLNSLTCFHIFHSRCVEnst-----fktRGCPNCKK 407 purple sea urchin XP_006814328 118 ALSCGVCNEvISEKPESLESLQCSHLFHASCLEeyta----gdsRGCPDCRR 165 Saccoglossus kowalevskii Q09485 371 QLFCNFCGQrYGLKDESLQALRCSHIFHEKCLHtyll---qrtdQTCPKCRC 419 Caenorhabditis elegans

Conserved Protein Domain FamilyRING-H2_Rapsyn

Conserved Protein Domain Family
RING-H2_Rapsyn