Conserved Protein Domain Family
Dickkopf_N
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pfam04706: Dickkopf_N (this model, PSSM-Id:309719 is obsolete and has been replaced by 461401)
Dickkopf N-terminal cysteine-rich region
Dickkopf proteins are a class of Wnt antagonists. They possess two conserved cysteine-rich regions. This family represents the N-terminal one. The C-terminal region has been found to share significant sequence similarity to the colipase fold, pfam01114, pfam02740.
Links
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Statistics
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PSSM-Id: 309719
Aligned: 49 rows
Threshold Bit Score: 37.3149
Created: 21-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q9PWH3        68 CESDEECGGEEFCFQSRG---------VCLQCKKRRKRCIRDAMCCPGNHCSNGVCI 115 zebrafish
Q54KK1       153 CYMDEDCPSGNFCYWGSNk-------nLCKPLNKIGSNCTYGNDFTLGSICRNNKCI 202 Dictyostelium discoideum AX4
NP_001083014 137 CMIDEDCGDGSFCLYEIVt-------sKCVPCQTTNMECTKDVECCGDQLCVWGVCA 186 zebrafish
ABF55256      69 CRKDKHCGQGKYCHRHYG---------TCHDVKPLGAHCRRDHVCAAGMECVFGKCr 116 starlet sea anemone
KZS15626      89 CMEDKQCGKGRFCDLHYG---------VCRTEKSPGFACRRDRMCGKGLACMFGRCQ 136 Daphnia magna
XP_003288255 122 CYSDSECGYNSYCKVSSPggpvgipmsICTS-KNAMGTCTSPNECSSG-VCVNGNCA 176 Dictyostelium purpureum
XP_003294997 122 CYSDNNCPYNYYCFLVGVsssgnngdgVCVP--KTSRNCESSNECSTGYTCIYGICV 176 Dictyostelium purpureum
XP_003291697 145 CSSDRECAYGNFCNITSEpdq----dnTCLPVLASSSVCTRDAQCPYNQICVKmafd 197 Dictyostelium purpureum
XP_007228393 125 CLIDEDCEQDSYCLYNISs-------sNCVPCKFTNMECVKDEECCGEQLCVWGLCV 174 Mexican tetra
XP_008409937 122 CMVDEDCGDLKYCLYEIEn-------sRCLPCIATDMPCSKDEECCSDQMCVWGQCT 171 guppy
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