4E4W


Conserved Protein Domain Family
Mlh1_C
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pfam16413: Mlh1_C (this model, PSSM-Id:293022 is obsolete and has been replaced by 465109)
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DNA mismatch repair protein Mlh1 C-terminus
This is the C-terminal domain of DNA mismatch repair protein Mlh1, these proteins belong to the MutL family. This domain forms part of the endonuclease active site.
Links
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Statistics
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PSSM-Id: 293022
Aligned: 189 rows
Threshold Bit Score: 127.599
Created: 25-Jul-2015
Updated: 5-Aug-2015
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4E4W_A         24 NVNLTSIKKLREKVDDSIH-RELTDIFANLNYVGVVDEerRLAAIQHDLKLFLIDYGSVCYELFYQIGLTDF-----A-- 95   Saccharomyces...
Q57TS9        621 flLLTSVSTIVSNIRAGTS-QTAQSLFQNLAYVGVLKG--HLFFAQSGTTLYVVDSLRLVRHVVYQRIFLRWatpslS-- 695  Trypanosoma b...
Q8IIJ0        708 adEISSIKKLKMICEEKEK-KELTECLKNSIYVGPVDN--MHSLIQYKEKLLLIKMPLIIKEVTYQSILNRL-----G-- 777  Plasmodium fa...
Q4Y1V0         27 cdEISSIKKLRKICEEKEK-KELTDCLKNSIYVGPVDN--IHSLIQYKEKLLMIKMPLIIKEIIYQSILNRI-----G-- 96   Plasmodium ch...
Q5CRJ3        546 FLTEIEIMNDNTEASKMEYlKSLTKNIINGIYIGQIKS--SWSIIQAKNQILLINIEQMSKIALKQSLICRL-----G-- 616  Cryptosporidi...
CCD76365      630 TVYLMSILALKRNLECDLD-QSIKNTLRSCKFIGFIDE--TRCLAQHHTELLLIRLKPLSQALFYQLLLTNF-----G-- 699  Schistosoma m...
GAA54102      580 iVRLNSVLQMRERIAANAD-EQAKRLLRSSKFVGLIDE--TRCLIQNSTDLLLARLVPLSTALFYQLMVFNF-----A-- 649  Clonorchis si...
XP_002259179  558 cdDISSIRKLKRICEEKEK-KELTECLKNSIYVGAVDN--LHSLIQYKDKLLMIKMPLIIKEITYQSILNRI-----G-- 627  Plasmodium kn...
EKG07438      475 DLLLTSVSTIVSQIRQTTS-PTVQSLFEKLVYVGVING--HMFLAQSGTTLYAVDTLRLVRLVVYQRIFMRW-----Sia 546  Trypanosoma c...
XP_002139205  541 lVTQRIIKNYWNNISEGIE-DDLARSLSNSIYIGLVKH--PICLVQAENELLLVNTKKMANLAIIQSIIDRL-----G-- 610  Cryptosporidi...

4E4W_A         96 ---NFGKINLqstnvsDD-IVLYNLLsefDELNDDA-------------------------SKEK----IISKI----WD 138  Saccharomyces...
Q57TS9        696 ---AVPQLSF------EEpIHLSDLL---SFALQNDvqlppsqk---------radggpgsLLSR----LGRRL----CN 746  Trypanosoma b...
Q8IIJ0        778 ---KIPPFEF------DPpIPLYDLL---LVAVNNSysgfyenpn--------yankniekVCNE----LEQIF----YT 829  Plasmodium fa...
Q4Y1V0         97 ---KIPPFKF------DPpIPLYDLL---LVGLNNSysgffenpk--------yanknverVCNE----LEQIF----YS 148  Plasmodium ch...
Q5CRJ3        617 ---YIPLLKL------NPpVSLGELS-----LFGTEsvk-------------------nykLNENdqiqLKDFI----NS 659  Cryptosporidi...
CCD76365      700 ---NHGEIIL------REpAPLADLL---SIGHEYLrkssryl-----------snlssieFIKE----ATATL----VK 748  Schistosoma m...
GAA54102      650 ---NHGEMIL------SEpAPVKELL---IM---SQsfgptsf-----------ksedpsaVVQN----AIQTL----QS 695  Clonorchis si...
XP_002259179  628 ---RIPPFKF------DPpIPLYDLL---LVAMNNsqsgyfe------------npdyvtkNIER----ICNELeqvfYS 679  Plasmodium kn...
EKG07438      547 slpAPPQMLL------EEpVRVTDLL---CFALQHDvppqtdvs----------laestqrTVRR----MDRCL----RQ 599  Trypanosoma c...
XP_002139205  611 ---RLPTLRF------NPpIDLREIF-----SLMENhynsksqfkyndnlfskytnsnlriNLEK----SVILL----NH 668  Cryptosporidi...

4E4W_A        139 MSSMLNEY---YSIELvndglD-NDlksVK--LKSLPLLLK-G-------------YIPSLVKLPFFIYRLGKEvDW-E- 196  Saccharomyces...
Q57TS9        747 WRYMLQDY---FAVEI-----S-AD---GH--LIALPLSMG-Ts------------WPPPLRAVPLFIWRLAAEvPY-Na 798  Trypanosoma b...
Q8IIJ0        830 YNEMYSDY---FSIII-------ED---GC--IVTFPACCG-E-------------YFPGQEFLPFLFLRLATQiDY-S- 878  Plasmodium fa...
Q4Y1V0        149 YEEMYADY---FSLVI-------ED---GH--IVTFPSCCG-E-------------YFPGQEFLPLLFLRLASQiDY-E- 197  Plasmodium ch...
Q5CRJ3        660 QAYLYFDIlkvLGIDF-----DsSN---NS--FSTLPLFFG-N-------------FVPNIDFLPELFEHVIFA-CW-Nf 713  Cryptosporidi...
CCD76365      749 HASMLWDY---FSIKIt---tD-SN---GNqvLTGIPLIIA-D-------------YIPELNQLPIYVTKLATQvSW-S- 802  Schistosoma m...
GAA54102      696 NSAMLWDY---FSMKF-----E-PD--------TA-----N-GdlmlvslplllqkYIPDLTRLPIYVMRLATEvNW-N- 750  Clonorchis si...
XP_002259179  680 YEEMYADY---FSIII-------ED---GC--VCTFPACCG-E-------------YFPGQEFLPLLFLRLATQvDY-E- 728  Plasmodium kn...
EKG07438      600 WRCMLLEY---FSIEI-----T-HD---GH--LLALPFGLNsS-------------WPPSPRVVPLFIWRLAAEvPYrE- 651  Trypanosoma c...
XP_002139205  669 YSSYISSI---FGIYI-----NvKN---MQ--LETFPLCFG-D-------------YLPNIDMLPNTLYQIISL------ 715  Cryptosporidi...

4E4W_A        197 -DEQECLDGILREIA-LLY---------------Ipdmvpkvdtsdasl------------------------------- 228  Saccharomyces...
Q57TS9        799 -GEIECFTAIARHIAeTLY---------------Gvqlhsswlpnvi--------------------------------- 829  Trypanosoma b...
Q8IIJ0        879 -KEINCINGICYLLA-NFY---------------Skitllndkewtyqddllmiqekekeiqmllnksnkhi-nnsnhhn 940  Plasmodium fa...
Q4Y1V0        198 -NEINCINGICYLLA-NFY---------------Skitltsdtewtyqdelkmikereigmlqnlkkgnnskndgqtegn 260  Plasmodium ch...
Q5CRJ3        714 hIAHACKQKLLNTGSaQIL---------------Nphfneennclsdk-------------------------------- 746  Cryptosporidi...
CCD76365      803 -VESICFENICCITA-NFY---------------Avssslfndcssspisssts-------------------------- 839  Schistosoma m...
GAA54102      751 -EEINCFEDICRITA-EFY---------------Apvpklsslstsekqaervski------------------------ 789  Clonorchis si...
XP_002259179  729 -NELNCINGICYLIA-NFY---------------Skvtllddkewtfqnellmlkeke---------------------- 769  Plasmodium kn...
EKG07438      652 -DEVACFTAIARHIAdTLYglrlhdawveprvspSpgveppgdgr----------------------------------- 695  Trypanosoma c...
XP_002139205  716 ------LDTFYDSIS-NLY---------------Qnilennlkpe----------------------------------- 738  Cryptosporidi...

4E4W_A        229 ---------------sedekaqfinrkehISSLLE-----------------HVL------------------------- 251  Saccharomyces...
Q57TS9        830 ------------------kdgirqddvppFCDAIR-----------------FGL------------------------- 849  Trypanosoma b...
Q8IIJ0        941 qhydetnldyilgdesvvdinkhlsvsrnINLVFE-----------------KYF------------------------- 978  Plasmodium fa...
Q4Y1V0        261 aqndninfdsilgdetvidvnkhlpvsknINLVFE-----------------KYF------------------------- 298  Plasmodium ch...
Q5CRJ3        747 -----------------isedyiiklyelFIELIEilvdyyl----fgiednELL------------------------- 780  Cryptosporidi...
CCD76365      840 ----------iiddksdkentvsssslspREWMIQ-----------------HIL------------------------- 867  Schistosoma m...
GAA54102      790 ---------dgdvegassyssseqtpevpVRWMIE-----------------HVL------------------------- 818  Clonorchis si...
XP_002259179  770 ------iqmlqgqattdgsgeasplanddQTYHFE-----------------NILgdetvidvnrhlaaskninlvfeky 826  Plasmodium kn...
EKG07438      696 --------------------geeggsvpsLFDAIR-----------------FAL------------------------- 713  Trypanosoma c...
XP_002139205  739 --------------------ilesnldnfANSLLEivkvislcyisgpecnsEHL------------------------- 773  Cryptosporidi...

4E4W_A        252 -FPCI---KR---RFLAP---------------RH-I-LKd-------------------VVEIANLPDLYKVFERC 285  Saccharomyces ce...
Q57TS9        850 -LPCAt-nST---FFVPP---------------CD-A-LVdg-----------------tVQAVVSVDELYKVFERC 887  Trypanosoma brucei
Q8IIJ0        979 -FPMIq-lNN---IMKIP---------------TT-F-SNng-----------------yIIELTSLNQLYKIFERC 1016 Plasmodium falci...
Q4Y1V0        299 -FPMIq-lNN---SMKIP---------------NI-F-STng-----------------yIIELTSLNQLYKIFERC 336  Plasmodium chabaudi
Q5CRJ3        781 -FQAIrnnNN---LILVE---------------DQ-I-SQn-------------------IIELSSLEKLYRVFERC 817  Cryptosporidium ...
CCD76365      868 -WPIL---CS---SLLPSrrypnfdldhnendnKS-FsLQs------------------cFIRLTSLTDLYKVFERC 918  Schistosoma mansoni
GAA54102      819 -WPAL---SS---SLIPG---------------HG-L-LYeapplsqlssqpqpasspcaFFRLTRLSDLYKVFERC 871  Clonorchis sinensis
XP_002259179  827 fFPMIq-lNT---IMRVP---------------RT-F-STng-----------------yIIELTSLNQLYKIFERC 865  Plasmodium knowl...
EKG07438      714 -LPCAt-sSK---LFVPP---------------ADaL-IDg------------------tIQTVVSVEELYKVFERC 751  Trypanosoma cruzi
XP_002139205  774 -FQAI---KRnncLVIPS---------------SS-L-DSt------------------tVIHVTSLEKLYRVFERC 811  Cryptosporidium ...
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