Conserved Protein Domain Family
Dickkopf_N
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pfam04706: Dickkopf_N (this model, PSSM-Id:282549 is obsolete and has been replaced by 461401)
Dickkopf N-terminal cysteine-rich region
Dickkopf proteins are a class of Wnt antagonizts. They possess two conserved cysteine-rich regions. This family represents the N-terminal one. The C-terminal region has been found to share significant sequence similarity to the colipase fold, pfam01114, pfam02740.
Links
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Statistics
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PSSM-Id: 282549
Aligned: 52 rows
Threshold Bit Score: 36.151
Created: 14-Jul-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q9PWH3        68 CESDEECGGEEFCFQSRG---------VCLQCKKRRKRCIRDAMCCPGNHCSNGVCI 115 zebrafish
Q54KK1       153 CYMDEDCPSGNFCYWGSNk-------nLCKPLNKIGSNCTYGNDFTLGSICRNNKCI 202 Dictyostelium discoideum AX4
XP_006001038 152 CILDEDCGAGTYCLSTILe-------tKCLPCKPEDMNCTRDGECCEEHLCVWGQCA 201 coelacanth
XP_005796296 124 CMVDEDCGDLKYCLYEIEn-------sRCLPCIATDMPCSKDEECCSDQMCVWGQCT 173 southern platyfish
NP_001116948  45 CIVDEDCKSGNYCYFADSe-------yKCLPCKAT-EPCTRDGECCEG-LCVWGQCA 92  western clawed frog
ABF55256      69 CRKDKHCGQGKYCHRHYG---------TCHDVKPLGAHCRRDHVCAAGMECVFGKCr 116 starlet sea anemone
EFX74373      96 CMEDKQCGKGRFCDLHYG---------VCRTEKSPGFACRRDRMCGKGLACMFGRCQ 143 common water flea
XP_003288255 122 CYSDSECGYNSYCKVSSPggpvgipmsICTS-KNAMGTCTSPNECSSG-VCVNGNCA 176 Dictyostelium purpureum
XP_003294997 122 CYSDNNCPYNYYCFLVGVsssgnngdgVCVP--KTSRNCESSNECSTGYTCIYGICV 176 Dictyostelium purpureum
XP_003291697 145 CSSDRECAYGNFCNITSEpdq----dnTCLPVLASSSVCTRDAQCPYNQICVKmafd 197 Dictyostelium purpureum
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