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Structure-guided optimization of a novel class of ASK1 inhibitors with increased sp3 character and an exquisite selectivity profile[METAL BINDING PROTEIN]
View in iCn3D Similar StructuresPubMedProteinsConserved DomainsPubChem Compound
Structure of ASK1 bound to BIO-1772961[TRANSFERASE]
ASK1 kinase domain in complex with Compound 11[TRANSFERASE]
ASK1 kinase domain in complex with GS-4997[Transferase/Transferase Inhibitor]
Structure of 14-3-3 zeta in complex with ASK1 14-3-3 binding motif[SIGNALING PROTEIN]
View in iCn3D Similar StructuresProteinsConserved DomainsPubChem Compound
Structure-Based Design of ASK1 Inhibitors as Potential First-in-Class Agents for Heart Failure[TRANSFERASE/TRANSFERASE INHIBITOR]
Structure-based drug design of novel ASK1 inhibitors using a fully integrated lead optimization strategy[TRANSFERASE/TRANSFERASE INHIBITOR]
Crystal Structures of Ask1-inhibitor Complexes[TRANSFERASE]
Crystal structure of human apoptosis signal-regulating kinase 1 (ASK1) with imidazopyridine inhibitor[TRANSFERASE/TRANSFERASE INHIBITOR]
Structure of mitogen-activated protein kinase kinase kinase 5[TRANSFERASE]
View in iCn3D Similar StructuresPubMedProteinsConserved DomainsPubChem CompoundBioAssay
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