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    ZNF536 zinc finger protein 536 [ Homo sapiens (human) ]

    Gene ID: 9745, updated on 3-Apr-2024

    Summary

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    Official Symbol
    ZNF536provided by HGNC
    Official Full Name
    zinc finger protein 536provided by HGNC
    Primary source
    HGNC:HGNC:29025
    See related
    Ensembl:ENSG00000198597 MIM:618037; AllianceGenome:HGNC:29025
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    The protein encoded by this gene is a highly conserved zinc finger protein. The encoded protein is most abundant in brain, where it negatively regulates neuronal differentiation. [provided by RefSeq, Sep 2015]
    Expression
    Biased expression in brain (RPKM 2.6), thyroid (RPKM 0.8) and 11 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    19q12
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (30225592..30713586)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (32746044..33234121)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (30716499..31204493)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14426 Neighboring gene VISTA enhancer hs382 Neighboring gene uncharacterized LOC107985271 Neighboring gene VISTA enhancer hs721 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14427 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:30583442-30583972 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:30583973-30584501 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:30589624-30589867 Neighboring gene TATA-box binding protein associated factor 9 pseudogene 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:30607607-30608158 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:30608159-30608708 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:30648008-30648968 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10475 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:30714014-30714514 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:30714515-30715015 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10476 Neighboring gene VISTA enhancer hs858 Neighboring gene VISTA enhancer hs383 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:30811773-30812272 Neighboring gene VISTA enhancer hs430 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr19:30864335-30864836 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:30866004-30866504 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:30875860-30876360 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:30948561-30949071 Neighboring gene VISTA enhancer hs384 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:31042441-31042941 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:31044111-31044612 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:31055005-31055756 Neighboring gene uncharacterized LOC124904685 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:31182908-31183532 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:31183533-31184155 Neighboring gene MPRA-validated peak3430 silencer Neighboring gene uncharacterized LOC105372354 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:31210807-31211306 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr19:31224870-31226069 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:31297953-31298452 Neighboring gene long intergenic non-protein coding RNA 1834

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Identification of the DNA binding specificity of the human ZNF219 protein and its function as a transcriptional repressor. Sakai T, et al. DNA Res, 2003 Aug 31. PMID 14621294
    2. ZNF536, a novel zinc finger protein specifically expressed in the brain, negatively regulates neuron differentiation by repressing retinoic acid-induced gene transcription. Qin Z, et al. Mol Cell Biol, 2009 Jul. PMID 19398580, Free PMC Article
    3. Functional genomic analysis of oligodendrocyte differentiation. Dugas JC, et al. J Neurosci, 2006 Oct 25. PMID 17065439, Free PMC Article
    4. Genome-wide association analysis demonstrates the highly polygenic character of age-related hearing impairment. Fransen E, et al. Eur J Hum Genet, 2015 Jan. PMID 24939585, Free PMC Article
    5. Genome-wide association with select biomarker traits in the Framingham Heart Study. Benjamin EJ, et al. BMC Med Genet, 2007 Sep 19. PMID 17903293, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ZFP536 promotes the late phase of oligodendrocyte differentiation.
      Title: Functional genomic analysis of oligodendrocyte differentiation.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide association study provides evidence for association of chromosome 8p23 (MYP10) and 10q21.1 (MYP15) with high myopia in the French Population.
    EBI GWAS Catalog
    Biological insights from 108 schizophrenia-associated genetic loci.
    EBI GWAS Catalog
    Genome-wide association analysis demonstrates the highly polygenic character of age-related hearing impairment.
    EBI GWAS Catalog
    Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan.
    EBI GWAS Catalog
    Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality.
    EBI GWAS Catalog
    Genome-wide association with select biomarker traits in the Framingham Heart Study.
    EBI GWAS Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of zinc finger protein 536 (ZNF536) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0390

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables retinoic acid-responsive element binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of retinoic acid receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 536

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001352260.2 → NP_001339189.1  zinc finger protein 536 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC011454, AC011478, AC011504, AC011532, DA205038, DT215826, HY151164, HY309977
      Consensus CDS
      CCDS92576.1
      UniProtKB/TrEMBL
      A0A994J7Z0, A7E228
      Related
      ENSP00000516233.1, ENST00000706150.1
      Conserved Domains (6) summary
      COG5048
      Location:103 → 180
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:753 → 773
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:753 → 773
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:765 → 787
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:779 → 802
      zf-H2C2_5; C2H2-type zinc-finger domain
      pfam16606
      Location:657 → 737
      zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers

    2. NM_001376110.1 → NP_001363039.1  zinc finger protein 536 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC005597, AC006506, AC011454, AC011504, AC011532
      Consensus CDS
      CCDS92577.1
      UniProtKB/TrEMBL
      A7E228, K7EQN6
      Conserved Domains (6) summary
      COG5048
      Location:103 → 180
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:753 → 773
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:753 → 773
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:765 → 787
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:779 → 802
      zf-H2C2_5; C2H2-type zinc-finger domain
      pfam16606
      Location:657 → 737
      zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers

    3. NM_001376111.1 → NP_001363040.1  zinc finger protein 536 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC005597, AC006506, AC011454, AC011504, AC011532
      Consensus CDS
      CCDS92577.1
      UniProtKB/TrEMBL
      A7E228, K7EQN6
      Conserved Domains (6) summary
      COG5048
      Location:103 → 180
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:753 → 773
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:753 → 773
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:765 → 787
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:779 → 802
      zf-H2C2_5; C2H2-type zinc-finger domain
      pfam16606
      Location:657 → 737
      zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers

    4. NM_014717.3 → NP_055532.1  zinc finger protein 536 isoform 1

      See identical proteins and their annotated locations for NP_055532.1

      Status: REVIEWED

      Source sequence(s)
      AC011454, BC146757, HY151164
      Consensus CDS
      CCDS32984.1
      UniProtKB/Swiss-Prot
      A2RU18, O15090
      UniProtKB/TrEMBL
      A7E228
      Related
      ENSP00000347730.1, ENST00000355537.4
      Conserved Domains (6) summary
      COG5048
      Location:103 → 180
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:753 → 773
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:753 → 773
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:765 → 787
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:779 → 802
      zf-H2C2_5; C2H2-type zinc-finger domain
      pfam16606
      Location:657 → 737
      zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      30225592..30713586
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047439770.1 → XP_047295726.1  zinc finger protein 536 isoform X2

      UniProtKB/TrEMBL
      K7EQN6

    2. XM_011527554.3 → XP_011525856.1  zinc finger protein 536 isoform X1

      See identical proteins and their annotated locations for XP_011525856.1

      UniProtKB/TrEMBL
      A7E228
      Conserved Domains (6) summary
      COG5048
      Location:103 → 180
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:132 → 152
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:753 → 773
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:145 → 169
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:808 → 831
      zf-H2C2_5; C2H2-type zinc-finger domain
      pfam16606
      Location:657 → 737
      zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers

    3. XM_047439763.1 → XP_047295719.1  zinc finger protein 536 isoform X1

    4. XM_047439779.1 → XP_047295735.1  zinc finger protein 536 isoform X5

      UniProtKB/Swiss-Prot
      A2RU18, O15090

    5. XM_047439781.1 → XP_047295737.1  zinc finger protein 536 isoform X5

      UniProtKB/Swiss-Prot
      A2RU18, O15090

    6. XM_047439774.1 → XP_047295730.1  zinc finger protein 536 isoform X4

    7. XM_047439775.1 → XP_047295731.1  zinc finger protein 536 isoform X5

      UniProtKB/Swiss-Prot
      A2RU18, O15090
      Related
      ENSP00000516228.1, ENST00000706144.1

    8. XM_047439776.1 → XP_047295732.1  zinc finger protein 536 isoform X5

      UniProtKB/Swiss-Prot
      A2RU18, O15090

    9. XM_017027532.2 → XP_016883021.1  zinc finger protein 536 isoform X1

      UniProtKB/TrEMBL
      A7E228
      Conserved Domains (6) summary
      COG5048
      Location:103 → 180
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:132 → 152
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:753 → 773
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:145 → 169
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:808 → 831
      zf-H2C2_5; C2H2-type zinc-finger domain
      pfam16606
      Location:657 → 737
      zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers

    10. XM_047439765.1 → XP_047295721.1  zinc finger protein 536 isoform X1

    11. XM_017027531.2 → XP_016883020.1  zinc finger protein 536 isoform X1

      UniProtKB/TrEMBL
      A7E228
      Conserved Domains (6) summary
      COG5048
      Location:103 → 180
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:132 → 152
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:753 → 773
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:145 → 169
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:808 → 831
      zf-H2C2_5; C2H2-type zinc-finger domain
      pfam16606
      Location:657 → 737
      zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers

    12. XM_047439764.1 → XP_047295720.1  zinc finger protein 536 isoform X1

    13. XM_047439767.1 → XP_047295723.1  zinc finger protein 536 isoform X2

      UniProtKB/TrEMBL
      K7EQN6

    14. XM_047439769.1 → XP_047295725.1  zinc finger protein 536 isoform X2

      UniProtKB/TrEMBL
      K7EQN6

    15. XM_047439778.1 → XP_047295734.1  zinc finger protein 536 isoform X5

      UniProtKB/Swiss-Prot
      A2RU18, O15090

    16. XM_047439780.1 → XP_047295736.1  zinc finger protein 536 isoform X5

      UniProtKB/Swiss-Prot
      A2RU18, O15090

    17. XM_047439785.1 → XP_047295741.1  zinc finger protein 536 isoform X5

      UniProtKB/Swiss-Prot
      A2RU18, O15090

    18. XM_017027533.2 → XP_016883022.1  zinc finger protein 536 isoform X1

      UniProtKB/TrEMBL
      A7E228
      Conserved Domains (6) summary
      COG5048
      Location:103 → 180
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:132 → 152
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:753 → 773
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:145 → 169
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:808 → 831
      zf-H2C2_5; C2H2-type zinc-finger domain
      pfam16606
      Location:657 → 737
      zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers

    19. XM_047439772.1 → XP_047295728.1  zinc finger protein 536 isoform X2

      UniProtKB/TrEMBL
      K7EQN6
      Related
      ENSP00000467909.3, ENST00000592773.3

    20. XM_017027535.2 → XP_016883024.1  zinc finger protein 536 isoform X1

      UniProtKB/TrEMBL
      A7E228
      Conserved Domains (6) summary
      COG5048
      Location:103 → 180
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:132 → 152
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:753 → 773
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:145 → 169
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:808 → 831
      zf-H2C2_5; C2H2-type zinc-finger domain
      pfam16606
      Location:657 → 737
      zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers

    21. XM_047439783.1 → XP_047295739.1  zinc finger protein 536 isoform X5

      UniProtKB/Swiss-Prot
      A2RU18, O15090
      Related
      ENSP00000516229.1, ENST00000706146.1

    22. XM_047439784.1 → XP_047295740.1  zinc finger protein 536 isoform X5

      UniProtKB/Swiss-Prot
      A2RU18, O15090

    23. XM_047439773.1 → XP_047295729.1  zinc finger protein 536 isoform X2

      UniProtKB/TrEMBL
      K7EQN6

    24. XM_047439766.1 → XP_047295722.1  zinc finger protein 536 isoform X1

    25. XM_017027530.2 → XP_016883019.1  zinc finger protein 536 isoform X1

      UniProtKB/TrEMBL
      A7E228
      Conserved Domains (6) summary
      COG5048
      Location:103 → 180
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:132 → 152
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:753 → 773
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:145 → 169
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:808 → 831
      zf-H2C2_5; C2H2-type zinc-finger domain
      pfam16606
      Location:657 → 737
      zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers

    26. XM_024451807.2 → XP_024307575.1  zinc finger protein 536 isoform X1

      UniProtKB/TrEMBL
      A7E228
      Conserved Domains (6) summary
      COG5048
      Location:103 → 180
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:132 → 152
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:753 → 773
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:145 → 169
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:808 → 831
      zf-H2C2_5; C2H2-type zinc-finger domain
      pfam16606
      Location:657 → 737
      zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers

    27. XM_017027529.2 → XP_016883018.1  zinc finger protein 536 isoform X1

      UniProtKB/TrEMBL
      A7E228
      Conserved Domains (6) summary
      COG5048
      Location:103 → 180
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:132 → 152
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:753 → 773
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:145 → 169
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:808 → 831
      zf-H2C2_5; C2H2-type zinc-finger domain
      pfam16606
      Location:657 → 737
      zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers

    28. XM_047439768.1 → XP_047295724.1  zinc finger protein 536 isoform X2

      UniProtKB/TrEMBL
      K7EQN6

    29. XM_017027534.2 → XP_016883023.1  zinc finger protein 536 isoform X1

      UniProtKB/TrEMBL
      A7E228
      Conserved Domains (6) summary
      COG5048
      Location:103 → 180
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:132 → 152
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:753 → 773
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:145 → 169
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:808 → 831
      zf-H2C2_5; C2H2-type zinc-finger domain
      pfam16606
      Location:657 → 737
      zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers

    30. XM_017027527.2 → XP_016883016.1  zinc finger protein 536 isoform X1

      UniProtKB/TrEMBL
      A7E228
      Conserved Domains (6) summary
      COG5048
      Location:103 → 180
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:132 → 152
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:753 → 773
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:145 → 169
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:808 → 831
      zf-H2C2_5; C2H2-type zinc-finger domain
      pfam16606
      Location:657 → 737
      zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers

    31. XM_017027537.2 → XP_016883026.1  zinc finger protein 536 isoform X2

      UniProtKB/TrEMBL
      A7E228, K7EQN6
      Conserved Domains (6) summary
      COG5048
      Location:103 → 180
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:753 → 773
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:753 → 773
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:765 → 787
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:779 → 802
      zf-H2C2_5; C2H2-type zinc-finger domain
      pfam16606
      Location:657 → 737
      zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers

    32. XM_017027528.2 → XP_016883017.1  zinc finger protein 536 isoform X1

      UniProtKB/TrEMBL
      A7E228
      Conserved Domains (6) summary
      COG5048
      Location:103 → 180
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:132 → 152
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:753 → 773
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:145 → 169
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:808 → 831
      zf-H2C2_5; C2H2-type zinc-finger domain
      pfam16606
      Location:657 → 737
      zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers

    33. XM_017027536.2 → XP_016883025.1  zinc finger protein 536 isoform X1

      UniProtKB/TrEMBL
      A7E228
      Conserved Domains (6) summary
      COG5048
      Location:103 → 180
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:132 → 152
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:753 → 773
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:145 → 169
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:808 → 831
      zf-H2C2_5; C2H2-type zinc-finger domain
      pfam16606
      Location:657 → 737
      zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers

    34. XM_011527558.3 → XP_011525860.1  zinc finger protein 536 isoform X1

      See identical proteins and their annotated locations for XP_011525860.1

      UniProtKB/TrEMBL
      A7E228
      Conserved Domains (6) summary
      COG5048
      Location:103 → 180
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:132 → 152
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:753 → 773
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:145 → 169
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:808 → 831
      zf-H2C2_5; C2H2-type zinc-finger domain
      pfam16606
      Location:657 → 737
      zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers

    35. XM_047439771.1 → XP_047295727.1  zinc finger protein 536 isoform X2

      UniProtKB/TrEMBL
      K7EQN6

    36. XM_047439782.1 → XP_047295738.1  zinc finger protein 536 isoform X5

      UniProtKB/Swiss-Prot
      A2RU18, O15090

    37. XM_017027539.2 → XP_016883028.1  zinc finger protein 536 isoform X3

      UniProtKB/TrEMBL
      A7E228
      Conserved Domains (6) summary
      COG5048
      Location:103 → 180
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:132 → 152
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:753 → 773
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:145 → 169
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:808 → 831
      zf-H2C2_5; C2H2-type zinc-finger domain
      pfam16606
      Location:657 → 737
      zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers

    38. XM_017027542.2 → XP_016883031.1  zinc finger protein 536 isoform X5

      UniProtKB/Swiss-Prot
      A2RU18, O15090
      UniProtKB/TrEMBL
      A7E228
      Conserved Domains (6) summary
      COG5048
      Location:103 → 180
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:753 → 773
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:753 → 773
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:765 → 787
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:779 → 802
      zf-H2C2_5; C2H2-type zinc-finger domain
      pfam16606
      Location:657 → 737
      zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers

    39. XM_047439777.1 → XP_047295733.1  zinc finger protein 536 isoform X5

      UniProtKB/Swiss-Prot
      A2RU18, O15090

    40. XM_047439786.1 → XP_047295742.1  zinc finger protein 536 isoform X5

      UniProtKB/Swiss-Prot
      A2RU18, O15090

    41. XM_011527557.3 → XP_011525859.1  zinc finger protein 536 isoform X1

      See identical proteins and their annotated locations for XP_011525859.1

      UniProtKB/TrEMBL
      A7E228
      Conserved Domains (6) summary
      COG5048
      Location:103 → 180
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:132 → 152
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:753 → 773
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:145 → 169
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:808 → 831
      zf-H2C2_5; C2H2-type zinc-finger domain
      pfam16606
      Location:657 → 737
      zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers

    42. XM_011527560.3 → XP_011525862.1  zinc finger protein 536 isoform X2

      UniProtKB/TrEMBL
      A7E228, K7EQN6
      Conserved Domains (6) summary
      COG5048
      Location:103 → 180
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:753 → 773
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:753 → 773
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:765 → 787
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:779 → 802
      zf-H2C2_5; C2H2-type zinc-finger domain
      pfam16606
      Location:657 → 737
      zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers

    43. XM_017027543.3 → XP_016883032.1  zinc finger protein 536 isoform X6

      UniProtKB/TrEMBL
      A0A994J5Q4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      32746044..33234121
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054322774.1 → XP_054178749.1  zinc finger protein 536 isoform X2

      UniProtKB/TrEMBL
      K7EQN6

    2. XM_054322754.1 → XP_054178729.1  zinc finger protein 536 isoform X1

    3. XM_054322753.1 → XP_054178728.1  zinc finger protein 536 isoform X1

    4. XM_054322786.1 → XP_054178761.1  zinc finger protein 536 isoform X5

      UniProtKB/Swiss-Prot
      A2RU18, O15090

    5. XM_054322788.1 → XP_054178763.1  zinc finger protein 536 isoform X5

      UniProtKB/Swiss-Prot
      A2RU18, O15090

    6. XM_054322780.1 → XP_054178755.1  zinc finger protein 536 isoform X4

    7. XM_054322782.1 → XP_054178757.1  zinc finger protein 536 isoform X5

      UniProtKB/Swiss-Prot
      A2RU18, O15090

    8. XM_054322783.1 → XP_054178758.1  zinc finger protein 536 isoform X5

      UniProtKB/Swiss-Prot
      A2RU18, O15090

    9. XM_054322765.1 → XP_054178740.1  zinc finger protein 536 isoform X1

    10. XM_054322760.1 → XP_054178735.1  zinc finger protein 536 isoform X1

    11. XM_054322756.1 → XP_054178731.1  zinc finger protein 536 isoform X1

    12. XM_054322758.1 → XP_054178733.1  zinc finger protein 536 isoform X1

    13. XM_054322771.1 → XP_054178746.1  zinc finger protein 536 isoform X2

      UniProtKB/TrEMBL
      K7EQN6

    14. XM_054322773.1 → XP_054178748.1  zinc finger protein 536 isoform X2

      UniProtKB/TrEMBL
      K7EQN6

    15. XM_054322785.1 → XP_054178760.1  zinc finger protein 536 isoform X5

      UniProtKB/Swiss-Prot
      A2RU18, O15090

    16. XM_054322787.1 → XP_054178762.1  zinc finger protein 536 isoform X5

      UniProtKB/Swiss-Prot
      A2RU18, O15090

    17. XM_054322792.1 → XP_054178767.1  zinc finger protein 536 isoform X5

      UniProtKB/Swiss-Prot
      A2RU18, O15090

    18. XM_054322766.1 → XP_054178741.1  zinc finger protein 536 isoform X1

    19. XM_054322777.1 → XP_054178752.1  zinc finger protein 536 isoform X2

      UniProtKB/TrEMBL
      K7EQN6

    20. XM_054322762.1 → XP_054178737.1  zinc finger protein 536 isoform X1

    21. XM_054322790.1 → XP_054178765.1  zinc finger protein 536 isoform X5

      UniProtKB/Swiss-Prot
      A2RU18, O15090

    22. XM_054322791.1 → XP_054178766.1  zinc finger protein 536 isoform X5

      UniProtKB/Swiss-Prot
      A2RU18, O15090

    23. XM_054322778.1 → XP_054178753.1  zinc finger protein 536 isoform X2

      UniProtKB/TrEMBL
      K7EQN6

    24. XM_054322768.1 → XP_054178743.1  zinc finger protein 536 isoform X1

    25. XM_054322757.1 → XP_054178732.1  zinc finger protein 536 isoform X1

    26. XM_054322764.1 → XP_054178739.1  zinc finger protein 536 isoform X1

    27. XM_054322759.1 → XP_054178734.1  zinc finger protein 536 isoform X1

    28. XM_054322772.1 → XP_054178747.1  zinc finger protein 536 isoform X2

      UniProtKB/TrEMBL
      K7EQN6

    29. XM_054322767.1 → XP_054178742.1  zinc finger protein 536 isoform X1

    30. XM_054322755.1 → XP_054178730.1  zinc finger protein 536 isoform X1

    31. XM_054322770.1 → XP_054178745.1  zinc finger protein 536 isoform X2

      UniProtKB/TrEMBL
      K7EQN6

    32. XM_054322752.1 → XP_054178727.1  zinc finger protein 536 isoform X1

    33. XM_054322769.1 → XP_054178744.1  zinc finger protein 536 isoform X1

    34. XM_054322763.1 → XP_054178738.1  zinc finger protein 536 isoform X1

    35. XM_054322775.1 → XP_054178750.1  zinc finger protein 536 isoform X2

      UniProtKB/TrEMBL
      K7EQN6

    36. XM_054322789.1 → XP_054178764.1  zinc finger protein 536 isoform X5

      UniProtKB/Swiss-Prot
      A2RU18, O15090

    37. XM_054322779.1 → XP_054178754.1  zinc finger protein 536 isoform X3

    38. XM_054322781.1 → XP_054178756.1  zinc finger protein 536 isoform X5

      UniProtKB/Swiss-Prot
      A2RU18, O15090

    39. XM_054322784.1 → XP_054178759.1  zinc finger protein 536 isoform X5

      UniProtKB/Swiss-Prot
      A2RU18, O15090

    40. XM_054322793.1 → XP_054178768.1  zinc finger protein 536 isoform X5

      UniProtKB/Swiss-Prot
      A2RU18, O15090

    41. XM_054322761.1 → XP_054178736.1  zinc finger protein 536 isoform X1

    42. XM_054322776.1 → XP_054178751.1  zinc finger protein 536 isoform X2

      UniProtKB/TrEMBL
      K7EQN6

    43. XM_054322794.1 → XP_054178769.1  zinc finger protein 536 isoform X6

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O15090.3 GenPept UniProtKB/Swiss-Prot:O15090

    Gene LinkOut

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