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    ZNF264 zinc finger protein 264 [ Homo sapiens (human) ]

    Gene ID: 9422, updated on 23-Mar-2024

    Summary

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    Official Symbol
    ZNF264provided by HGNC
    Official Full Name
    zinc finger protein 264provided by HGNC
    Primary source
    HGNC:HGNC:13057
    See related
    Ensembl:ENSG00000083844 MIM:604668; AllianceGenome:HGNC:13057
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene encodes a zinc finger protein and belongs to the krueppel C2H2-type zinc-finger protein family. Zinc finger proteins are often localized in the nucleus, bind nucleic acids, and regulate transcription. [provided by RefSeq, Jan 2010]
    Expression
    Ubiquitous expression in thyroid (RPKM 2.8), testis (RPKM 2.6) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZNF264 in Genome Data Viewer
    Location:
    19q13.43
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (57191500..57222846)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (60288010..60319383)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (57702868..57734214)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene double homeobox A Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11071 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15123 Neighboring gene uncharacterized LOC124904780 Neighboring gene pentatricopeptide repeat domain 3 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15124 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15125 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15126 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11072 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15127 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15128 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11073 Neighboring gene aurora kinase C Neighboring gene Sharpr-MPRA regulatory region 2652 Neighboring gene zinc finger protein 805

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Imprinting and evolution of two Kruppel-type zinc-finger genes, ZIM3 and ZNF264, located in the PEG3/USP29 imprinted domain. Kim J, et al. Genomics, 2001 Sep. PMID 11543637
    2. Wnt signaling and Dupuytren's disease. Dolmans GH, et al. N Engl J Med, 2011 Jul 28. PMID 21732829
    3. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. Ishikawa K, et al. DNA Res, 1997 Oct 31. PMID 9455477
    4. Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation. Nozawa RS, et al. Nat Cell Biol, 2010 Jul. PMID 20562864
    5. The DNA sequence and biology of human chromosome 19. Grimwood J, et al. Nature, 2004 Apr 1. PMID 15057824

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Copy number response

    Description
    Copy number response
    Haploinsufficency

    No evidence available (Last evaluated 2012-05-10)

    ClinGen Genome Curation Page
    Triplosensitivity

    No evidence available (Last evaluated 2012-05-10)

    ClinGen Genome Curation Page

    EBI GWAS Catalog

    Description
    Wnt signaling and Dupuytren's disease.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 264

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016432.1 RefSeqGene

      Range
      5001..36347
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_003417.5 → NP_003408.1  zinc finger protein 264

      See identical proteins and their annotated locations for NP_003408.1

      Status: REVIEWED

      Source sequence(s)
      AB007872, AC005261, AK292504, BF063192
      Consensus CDS
      CCDS33127.1
      UniProtKB/Swiss-Prot
      A8K8Y9, O43296, Q9P1V0
      Related
      ENSP00000263095.5, ENST00000263095.10
      Conserved Domains (6) summary
      smart00349
      Location:14 → 74
      KRAB; krueppel associated box
      COG5048
      Location:184 → 568
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:485 → 505
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:399 → 421
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:14 → 53
      KRAB; KRAB box
      pfam13465
      Location:413 → 438
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      57191500..57222846
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011527522.3 → XP_011525824.1  zinc finger protein 264 isoform X2

      Conserved Domains (6) summary
      smart00349
      Location:14 → 56
      KRAB; krueppel associated box
      COG5048
      Location:152 → 536
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:453 → 473
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:367 → 389
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:14 → 53
      KRAB; KRAB box
      pfam13465
      Location:381 → 406
      zf-H2C2_2; Zinc-finger double domain

    2. XM_047439724.1 → XP_047295680.1  zinc finger protein 264 isoform X1

      UniProtKB/Swiss-Prot
      A8K8Y9, O43296, Q9P1V0

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      60288010..60319383
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054322684.1 → XP_054178659.1  zinc finger protein 264 isoform X1

      UniProtKB/TrEMBL
      Q14C61, Q14C62

    2. XM_054322685.1 → XP_054178660.1  zinc finger protein 264 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O43296.1 GenPept UniProtKB/Swiss-Prot:O43296

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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