GPRC5A G protein-coupled receptor class C group 5 member A [Homo sapiens (human)] - Gene

Summary

Official Symbol: GPRC5Aprovided by HGNC
Official Full Name: G protein-coupled receptor class C group 5 member Aprovided by HGNC
Primary source: HGNC:HGNC:9836
See related: Ensembl:ENSG00000013588 MIM:604138; AllianceGenome:HGNC:9836
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: RAI3; TIG1; RAIG1; GPCR5A; PEIG-1
Summary: This gene encodes a member of the type 3 G protein-coupling receptor family, characterized by the signature 7-transmembrane domain motif. The encoded protein may be involved in interaction between retinoid acid and G protein signalling pathways. Retinoic acid plays a critical role in development, cellular growth, and differentiation. This gene may play a role in embryonic development and epithelial cell differentiation. [provided by RefSeq, Jul 2008]
Expression: Biased expression in lung (RPKM 125.2), colon (RPKM 33.4) and 9 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 12p13.1

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	12	NC_000012.12 (12891562..12917937)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	12	NC_060936.1 (12765164..12791546)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	12	NC_000012.11 (13044496..13070871)

Chromosome 12 - NC_000012.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Influence of GPRC5A-Regulated ABCB1 Expression on Lung Adenocarcinoma Proliferation.
Title: Influence of GPRC5A-Regulated ABCB1 Expression on Lung Adenocarcinoma Proliferation.
[Inhibitory effect of downregulating G protein-coupled receptor class C group 5 member A expression on lipopolysaccharide-induced inflammatory response in human gingival fibroblasts].
Title: [Inhibitory effect of downregulating G protein-coupled receptor class C group 5 member A expression on lipopolysaccharide-induced inflammatory response in human gingival fibroblasts].
Deciphering the molecular regulatory of RAB32/GPRC5A axis in chronic obstructive pulmonary disease.
Title: Deciphering the molecular regulatory of RAB32/GPRC5A axis in chronic obstructive pulmonary disease.
The G protein-coupled receptor GPRC5A-a phorbol ester and retinoic acid-induced orphan receptor with roles in cancer, inflammation, and immunity.
Title: The G protein-coupled receptor GPRC5A-a phorbol ester and retinoic acid-induced orphan receptor with roles in cancer, inflammation, and immunity.
RAI3 expression is not associated with clinical outcomes of patients with non-small cell lung cancer.
Title: RAI3 expression is not associated with clinical outcomes of patients with non-small cell lung cancer.
Knockdown of GPRC5A inhibits cell proliferation, migration and invasion in osteosarcoma.
Title: Knockdown of GPRC5A inhibits cell proliferation, migration and invasion in osteosarcoma.
Prognostic and clinicopathological significance of GPRC5A in various cancers: A systematic review and meta-analysis.
Title: Prognostic and clinicopathological significance of GPRC5A in various cancers: A systematic review and meta-analysis.
GPRC5a suppresses the proliferation of non-small cell lung cancer under wild type p53 background.
Title: GPRC5a suppresses the proliferation of non-small cell lung cancer under wild type p53 background.
Adaptive RSK-EphA2-GPRC5A signaling switch triggers chemotherapy resistance in ovarian cancer.
Title: Adaptive RSK-EphA2-GPRC5A signaling switch triggers chemotherapy resistance in ovarian cancer.
RhoA/C inhibits proliferation by inducing the synthesis of GPRC5A.
Title: RhoA/C inhibits proliferation by inducing the synthesis of GPRC5A.

Submit: New GeneRIF Correction See all GeneRIFs (43)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Gprc5a (e-PCR), detects polymorphism
- UniSTS:536578

D12S2123 (e-PCR)
- UniSTS:67885

RH99002 (e-PCR)
- UniSTS:86602

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables cadherin binding	HDA more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of epidermal growth factor-activated receptor activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in signal transduction	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasmic vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in extracellular exosome	HDA more info	PubMed
is_active_in extracellular exosome	IBA Inferred from Biological aspect of Ancestor more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
located_in intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info
located_in nucleolus	IDA Inferred from Direct Assay more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info
located_in vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: retinoic acid-induced protein 3

Names: G-protein coupled receptor family C group 5 member A; TPA induced gene 1; orphan G-protein-coupling receptor PEIG-1; phorbol ester induced gene 1; phorbol ester induced protein-1; retinoic acid induced 3; retinoic acid responsive; retinoic acid-induced gene 1 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_003979.4 → NP_003970.1 retinoic acid-induced protein 3

See identical proteins and their annotated locations for NP_003970.1

Status: REVIEWED

Source sequence(s)

AC007688, AF095448, AI587426, AK122672

Consensus CDS

CCDS8657.1

UniProtKB/Swiss-Prot

B3KV45, O95357, Q8NFJ5

UniProtKB/TrEMBL

A8K556

Related

ENSP00000014914.6, ENST00000014914.6

Conserved Domains (1) summary

cd15279
Location:26 → 270

7tmC_RAIG1_4_GPRC5A_D; retinoic acid-inducible orphan G-protein-coupled receptors 1 and 4; class C family of seven-transmembrane G protein-coupled receptors, group 5, member A and D