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    ZNF217 zinc finger protein 217 [ Homo sapiens (human) ]

    Gene ID: 7764, updated on 5-May-2024

    Summary

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    Official Symbol
    ZNF217provided by HGNC
    Official Full Name
    zinc finger protein 217provided by HGNC
    Primary source
    HGNC:HGNC:13009
    See related
    Ensembl:ENSG00000171940 MIM:602967; AllianceGenome:HGNC:13009
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZABC1
    Summary
    Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in mitochondrion and nuclear speck. Part of histone deacetylase complex. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in urinary bladder (RPKM 14.5), spleen (RPKM 14.3) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    20q13.2
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (53567071..53597702, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (55339255..55382109, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (52183610..52210378, complement)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene teashirt zinc finger homeobox 2 Neighboring gene uncharacterized LOC105372669 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:52077141-52077719 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:52077720-52078297 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:52089451-52090068 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:52120609-52121259 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:52126933-52127434 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:52127435-52127934 Neighboring gene uncharacterized LOC105372671 Neighboring gene reporter assay-validated silencer 6 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:52173455-52173955 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:52175886-52176069 Neighboring gene ZNF217 antisense RNA 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:52189693-52189843 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:52198379-52199170 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13051 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13050 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13049 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13048 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18121 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:52214839-52215339 Neighboring gene uncharacterized LOC105372672 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18122 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18123 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:52238084-52238848 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:52243436-52243628 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18124 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18125 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18126 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18127 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18128 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18129 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18130 Neighboring gene RNA, U7 small nuclear 14 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Implication of ZNF217 in Accelerating Tumor Development and Therapeutically Targeting ZNF217-Induced PI3K-AKT Signaling for the Treatment of Metastatic Osteosarcoma. Smeester BA, et al. Mol Cancer Ther, 2020 Dec. PMID 32999043, Free PMC Article
    2. Stiff stroma increases breast cancer risk by inducing the oncogene ZNF217. Northey JJ, et al. J Clin Invest, 2020 Nov 2. PMID 32721948, Free PMC Article
    3. Zinc finger gene 217 (ZNF217) Promoted Ovarian Hyperstimulation Syndrome (OHSS) through Regulating E(2) Synthesis and Inhibiting Thrombospondin-1 (TSP-1). Zhai J, et al. Sci Rep, 2017 Jun 12. PMID 28607476, Free PMC Article
    4. The critical role of the ZNF217 oncogene in promoting breast cancer metastasis to the bone. Bellanger A, et al. J Pathol, 2017 May. PMID 28207159
    5. Elevated expression of ZNF217 promotes prostate cancer growth by restraining ferroportin-conducted iron egress. Jiang X, et al. Oncotarget, 2016 Dec 20. PMID 27768596, Free PMC Article

    See all (92) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Frequent ZNF217 mutations lead to transcriptional deregulation of interferon signal transduction via altered chromatin accessibility in B cell lymphoma.
      Title: Frequent ZNF217 mutations lead to transcriptional deregulation of interferon signal transduction via altered chromatin accessibility in B cell lymphoma.
    2. FTO-stabilized miR-139-5p targets ZNF217 to suppress prostate cancer cell malignancies by inactivating the PI3K/Akt/mTOR signal pathway.
      Title: FTO-stabilized miR-139-5p targets ZNF217 to suppress prostate cancer cell malignancies by inactivating the PI3K/Akt/mTOR signal pathway.
    3. Hsa_circ_0069094 positively regulates the expression of oncogenic ZNF217 by competitively targeting miR-758-3p to promote the development of breast cancer.
      Title: Hsa_circ_0069094 positively regulates the expression of oncogenic ZNF217 by competitively targeting miR-758-3p to promote the development of breast cancer.
    4. MicroRNA-135 inhibits initiation of epithelial-mesenchymal transition in breast cancer by targeting ZNF217 and promoting m6A modification of NANOG.
      Title: MicroRNA-135 inhibits initiation of epithelial-mesenchymal transition in breast cancer by targeting ZNF217 and promoting m6A modification of NANOG.
    5. Interferon regulatory factor 5induced upregulation of zincfinger protein 217 promotes pancreatic carcinoma progression.
      Title: Interferon regulatory factor 5‑induced upregulation of zinc‑finger protein 217 promotes pancreatic carcinoma progression.
    6. lncRNA SNHG1 Knockdown Alleviates Amyloid-beta-Induced Neuronal Injury by Regulating ZNF217 via Sponging miR-361-3p in Alzheimer's Disease.
      Title: lncRNA SNHG1 Knockdown Alleviates Amyloid-β-Induced Neuronal Injury by Regulating ZNF217 via Sponging miR-361-3p in Alzheimer's Disease.
    7. Implication of ZNF217 in Accelerating Tumor Development and Therapeutically Targeting ZNF217-Induced PI3K-AKT Signaling for the Treatment of Metastatic Osteosarcoma.
      Title: Implication of ZNF217 in Accelerating Tumor Development and Therapeutically Targeting ZNF217-Induced PI3K-AKT Signaling for the Treatment of Metastatic Osteosarcoma.
    8. Stiff stroma increases breast cancer risk by inducing the oncogene ZNF217.
      Title: Stiff stroma increases breast cancer risk by inducing the oncogene ZNF217.
    9. Indicated ZNF217 could recruit LSD1 to affect CDH1 epigenetic expression from transcription level.
      Title: The coordination between ZNF217 and LSD1 contributes to hepatocellular carcinoma progress and is negatively regulated by miR-101.
    10. ZNF217 inhibited both COX2 and PGE2 synthesis through estradiol in KGN cells. ZNF217 and aromatase were decreased, whereas COX2 and PGE2 were increased in the GC of women with PCOS
      Title: A candidate pathogenic gene, zinc finger gene 217 (ZNF217), may contribute to polycystic ovary syndrome through prostaglandin E2.
    Submit: New GeneRIF Correction See all GeneRIFs (46)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of histone deacetylase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 217

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001385034.1 → NP_001371963.1  zinc finger protein 217 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL157838
      UniProtKB/TrEMBL
      A8K2T5
      Conserved Domains (7) summary
      PHA03247
      Location:750 → 970
      PHA03247; large tegument protein UL36; Provisional
      COG5048
      Location:468 → 733
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:130 → 150
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:473 → 493
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:472 → 493
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:485 → 510
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:499 → 523
      zf-H2C2_5; C2H2-type zinc-finger domain

    2. NM_006526.3 → NP_006517.1  zinc finger protein 217 isoform 2

      See identical proteins and their annotated locations for NP_006517.1

      Status: REVIEWED

      Source sequence(s)
      AL157838
      Consensus CDS
      CCDS13443.1
      UniProtKB/Swiss-Prot
      E1P5Y6, O75362, Q14DB8
      UniProtKB/TrEMBL
      A8K2T5
      Related
      ENSP00000360526.2, ENST00000371471.7
      Conserved Domains (5) summary
      sd00017
      Location:130 → 150
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:473 → 493
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:472 → 493
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:485 → 510
      zf-H2C2_2; Zinc-finger double domain
      cl26464
      Location:750 → 938
      Atrophin-1; Atrophin-1 family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      53567071..53597702 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011529036.2 → XP_011527338.1  zinc finger protein 217 isoform X1

      See identical proteins and their annotated locations for XP_011527338.1

      UniProtKB/TrEMBL
      A8K2T5
      Conserved Domains (7) summary
      PHA03247
      Location:750 → 970
      PHA03247; large tegument protein UL36; Provisional
      COG5048
      Location:468 → 733
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:130 → 150
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:473 → 493
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:472 → 493
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:485 → 510
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:499 → 523
      zf-H2C2_5; C2H2-type zinc-finger domain

    2. XM_047440462.1 → XP_047296418.1  zinc finger protein 217 isoform X1

    3. XM_005260545.5 → XP_005260602.1  zinc finger protein 217 isoform X1

      See identical proteins and their annotated locations for XP_005260602.1

      UniProtKB/TrEMBL
      A8K2T5
      Conserved Domains (7) summary
      PHA03247
      Location:750 → 970
      PHA03247; large tegument protein UL36; Provisional
      COG5048
      Location:468 → 733
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:130 → 150
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:473 → 493
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:472 → 493
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:485 → 510
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:499 → 523
      zf-H2C2_5; C2H2-type zinc-finger domain

    4. XM_047440459.1 → XP_047296415.1  zinc finger protein 217 isoform X1

    5. XM_024451997.2 → XP_024307765.1  zinc finger protein 217 isoform X1

      UniProtKB/TrEMBL
      A8K2T5
      Conserved Domains (7) summary
      PHA03247
      Location:750 → 970
      PHA03247; large tegument protein UL36; Provisional
      COG5048
      Location:468 → 733
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:130 → 150
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:473 → 493
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:472 → 493
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:485 → 510
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:499 → 523
      zf-H2C2_5; C2H2-type zinc-finger domain

    6. XM_047440461.1 → XP_047296417.1  zinc finger protein 217 isoform X1

    7. XM_024451998.2 → XP_024307766.1  zinc finger protein 217 isoform X1

      UniProtKB/TrEMBL
      A8K2T5
      Conserved Domains (7) summary
      PHA03247
      Location:750 → 970
      PHA03247; large tegument protein UL36; Provisional
      COG5048
      Location:468 → 733
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:130 → 150
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:473 → 493
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:472 → 493
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:485 → 510
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:499 → 523
      zf-H2C2_5; C2H2-type zinc-finger domain

    8. XM_047440460.1 → XP_047296416.1  zinc finger protein 217 isoform X1

    9. XM_047440464.1 → XP_047296420.1  zinc finger protein 217 isoform X2

      UniProtKB/Swiss-Prot
      E1P5Y6, O75362, Q14DB8

    10. XM_047440463.1 → XP_047296419.1  zinc finger protein 217 isoform X2

      UniProtKB/Swiss-Prot
      E1P5Y6, O75362, Q14DB8

    11. XM_047440465.1 → XP_047296421.1  zinc finger protein 217 isoform X2

      UniProtKB/Swiss-Prot
      E1P5Y6, O75362, Q14DB8

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      55339255..55382109 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054323963.1 → XP_054179938.1  zinc finger protein 217 isoform X1

    2. XM_054323969.1 → XP_054179944.1  zinc finger protein 217 isoform X1

    3. XM_054323965.1 → XP_054179940.1  zinc finger protein 217 isoform X1

    4. XM_054323964.1 → XP_054179939.1  zinc finger protein 217 isoform X1

    5. XM_054323967.1 → XP_054179942.1  zinc finger protein 217 isoform X1

    6. XM_054323968.1 → XP_054179943.1  zinc finger protein 217 isoform X1

    7. XM_054323966.1 → XP_054179941.1  zinc finger protein 217 isoform X1

    8. XM_054323971.1 → XP_054179946.1  zinc finger protein 217 isoform X2

    9. XM_054323970.1 → XP_054179945.1  zinc finger protein 217 isoform X2

    10. XM_054323972.1 → XP_054179947.1  zinc finger protein 217 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O75362.1 GenPept UniProtKB/Swiss-Prot:O75362

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