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    RAB27B RAB27B, member RAS oncogene family [ Homo sapiens (human) ]

    Gene ID: 5874, updated on 11-Apr-2024

    Summary

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    Official Symbol
    RAB27Bprovided by HGNC
    Official Full Name
    RAB27B, member RAS oncogene familyprovided by HGNC
    Primary source
    HGNC:HGNC:9767
    See related
    Ensembl:ENSG00000041353 MIM:603869; AllianceGenome:HGNC:9767
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C25KG
    Summary
    Enables guanyl ribonucleotide binding activity; myosin V binding activity; and protein domain specific binding activity. Involved in multivesicular body sorting pathway and positive regulation of exocytosis. Located in Golgi stack and cytoplasmic vesicle. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in stomach (RPKM 15.0), prostate (RPKM 9.9) and 13 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    18q21.2
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (54717857..54895516)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (54920965..55098601)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (52385088..52562747)

    Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904308 Neighboring gene DYNAP pseuodgene 3 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:52274507-52275298 Neighboring gene dynactin associated protein Neighboring gene Sharpr-MPRA regulatory region 14135 Neighboring gene Sharpr-MPRA regulatory region 5858 Neighboring gene ribosomal protein SA pseudogene 57 Neighboring gene Sharpr-MPRA regulatory region 14713 Neighboring gene ReSE screen-validated silencer GRCh37_chr18:52573135-52573366 Neighboring gene coiled-coil domain containing 68 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr18:52635171-52636370 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr18:52642293-52643492 Neighboring gene microtubule associated protein 1 light chain 3 pseudogene Neighboring gene uncharacterized LOC107985125

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Rab27b, a Regulator of Exosome Secretion, Is Associated With Peritoneal Metastases in Gastric Cancer. Nambara S, et al. Cancer Genomics Proteomics, 2023 Jan-Feb. PMID 36581340, Free PMC Article
    2. Human multipotent mesenchymal stromal cells cytokine priming promotes RAB27B-regulated secretion of small extracellular vesicles with immunomodulatory cargo. Cheng A, et al. Stem Cell Res Ther, 2020 Dec 14. PMID 33317598, Free PMC Article
    3. Abnormal expression of Rab27B in prostatic epithelial cells of benign prostatic hyperplasia alters intercellular communication. Dai Y, et al. Int J Biochem Cell Biol, 2021 Feb. PMID 33285290
    4. Rab27B enhances drug resistance in hepatocellular carcinoma by promoting exosome-mediated drug efflux. Li R, et al. Carcinogenesis, 2020 Nov 13. PMID 32390047
    5. Oncogenic effects of RAB27B through exosome independent function in renal cell carcinoma including sunitinib-resistant. Tsuruda M, et al. PLoS One, 2020. PMID 32379831, Free PMC Article

    See all (75) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RAB27B-regulated exosomes mediate LSC maintenance via resistance to senescence and crosstalk with the microenvironment.
      Title: RAB27B-regulated exosomes mediate LSC maintenance via resistance to senescence and crosstalk with the microenvironment.
    2. Rab27b promotes endometriosis by enhancing invasiveness of ESCs and promoting angiogenesis.
      Title: Rab27b promotes endometriosis by enhancing invasiveness of ESCs and promoting angiogenesis.
    3. RAB27B controls palmitoylation-dependent NRAS trafficking and signaling in myeloid leukemia.
      Title: RAB27B controls palmitoylation-dependent NRAS trafficking and signaling in myeloid leukemia.
    4. RAB27B Drives a Cancer Stem Cell Phenotype in NSCLC Cells Through Enhanced Extracellular Vesicle Secretion.
      Title: RAB27B Drives a Cancer Stem Cell Phenotype in NSCLC Cells Through Enhanced Extracellular Vesicle Secretion.
    5. Rab27b, a Regulator of Exosome Secretion, Is Associated With Peritoneal Metastases in Gastric Cancer.
      Title: Rab27b, a Regulator of Exosome Secretion, Is Associated With Peritoneal Metastases in Gastric Cancer.
    6. RAB27A and RAB27B Expression May Predict Lymph Node Metastasis and Survival in Patients With Gastric Cancer.
      Title: RAB27A and RAB27B Expression May Predict Lymph Node Metastasis and Survival in Patients With Gastric Cancer.
    7. NRF2 promotes urothelial cell response to bacterial infection by regulating reactive oxygen species and RAB27B expression.
      Title: NRF2 promotes urothelial cell response to bacterial infection by regulating reactive oxygen species and RAB27B expression.
    8. Abnormal expression of Rab27B in prostatic epithelial cells of benign prostatic hyperplasia alters intercellular communication.
      Title: Abnormal expression of Rab27B in prostatic epithelial cells of benign prostatic hyperplasia alters intercellular communication.
    9. Human multipotent mesenchymal stromal cells cytokine priming promotes RAB27B-regulated secretion of small extracellular vesicles with immunomodulatory cargo.
      Title: Human multipotent mesenchymal stromal cells cytokine priming promotes RAB27B-regulated secretion of small extracellular vesicles with immunomodulatory cargo.
    10. Rab27B enhances drug resistance in hepatocellular carcinoma by promoting exosome-mediated drug efflux.
      Title: Rab27B enhances drug resistance in hepatocellular carcinoma by promoting exosome-mediated drug efflux.
    Submit: New GeneRIF Correction See all GeneRIFs (40)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GDP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables myosin V binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in anterograde axonal protein transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in multivesicular body sorting pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptic vesicle endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi stack IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in apical plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in axon cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in exocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    located_in late endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in melanosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in melanosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in multivesicular body membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in platelet dense granule membrane TAS
    Traceable Author Statement
    more info
    		  
    is_active_in secretory granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synaptic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in trans-Golgi network transport vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in zymogen granule membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ras-related protein Rab-27B
    NP_001362256.1
    NP_004154.2
    XP_006722581.1
    XP_016881402.1
    XP_016881403.1
    XP_024307000.1
    XP_047293681.1
    XP_047293682.1
    XP_054174925.1
    XP_054174926.1
    XP_054174927.1
    XP_054174928.1
    XP_054174929.1
    XP_054174930.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001375327.1 → NP_001362256.1  ras-related protein Rab-27B

      Status: VALIDATED

      Source sequence(s)
      AC007673, AC098848, AC100776
      Consensus CDS
      CCDS11958.1
      UniProtKB/Swiss-Prot
      B2RAB0, O00194, Q9BZB6
      Conserved Domains (1) summary
      cd04127
      Location:6 → 185
      Rab27A; Rab GTPase family 27a (Rab27a)

    2. NM_004163.4 → NP_004154.2  ras-related protein Rab-27B

      See identical proteins and their annotated locations for NP_004154.2

      Status: VALIDATED

      Source sequence(s)
      AC098848, AF329499
      Consensus CDS
      CCDS11958.1
      UniProtKB/Swiss-Prot
      B2RAB0, O00194, Q9BZB6
      Related
      ENSP00000262094.4, ENST00000262094.10
      Conserved Domains (1) summary
      cd04127
      Location:6 → 185
      Rab27A; Rab GTPase family 27a (Rab27a)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

      Range
      54717857..54895516
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017025913.2 → XP_016881402.1  ras-related protein Rab-27B isoform X1

      UniProtKB/Swiss-Prot
      B2RAB0, O00194, Q9BZB6
      Conserved Domains (1) summary
      cd04127
      Location:6 → 185
      Rab27A; Rab GTPase family 27a (Rab27a)

    2. XM_006722518.2 → XP_006722581.1  ras-related protein Rab-27B isoform X2

      See identical proteins and their annotated locations for XP_006722581.1

      Conserved Domains (2) summary
      smart00174
      Location:12 → 170
      RHO; Rho (Ras homology) subfamily of Ras-like small GTPases
      cl21455
      Location:6 → 156
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    3. XM_017025914.2 → XP_016881403.1  ras-related protein Rab-27B isoform X1

      UniProtKB/Swiss-Prot
      B2RAB0, O00194, Q9BZB6
      Conserved Domains (1) summary
      cd04127
      Location:6 → 185
      Rab27A; Rab GTPase family 27a (Rab27a)

    4. XM_047437725.1 → XP_047293681.1  ras-related protein Rab-27B isoform X1

      UniProtKB/Swiss-Prot
      B2RAB0, O00194, Q9BZB6

    5. XM_047437726.1 → XP_047293682.1  ras-related protein Rab-27B isoform X1

      UniProtKB/Swiss-Prot
      B2RAB0, O00194, Q9BZB6

    6. XM_024451232.2 → XP_024307000.1  ras-related protein Rab-27B isoform X1

      UniProtKB/Swiss-Prot
      B2RAB0, O00194, Q9BZB6
      Conserved Domains (1) summary
      cd04127
      Location:6 → 185
      Rab27A; Rab GTPase family 27a (Rab27a)

    RNA

    1. XR_007066208.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060942.1 Alternate T2T-CHM13v2.0

      Range
      54920965..55098601
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054318951.1 → XP_054174926.1  ras-related protein Rab-27B isoform X1

      UniProtKB/Swiss-Prot
      B2RAB0, O00194, Q9BZB6

    2. XM_054318950.1 → XP_054174925.1  ras-related protein Rab-27B isoform X1

      UniProtKB/Swiss-Prot
      B2RAB0, O00194, Q9BZB6

    3. XM_054318955.1 → XP_054174930.1  ras-related protein Rab-27B isoform X2

    4. XM_054318953.1 → XP_054174928.1  ras-related protein Rab-27B isoform X1

      UniProtKB/Swiss-Prot
      B2RAB0, O00194, Q9BZB6

    5. XM_054318952.1 → XP_054174927.1  ras-related protein Rab-27B isoform X1

      UniProtKB/Swiss-Prot
      B2RAB0, O00194, Q9BZB6

    6. XM_054318954.1 → XP_054174929.1  ras-related protein Rab-27B isoform X1

      UniProtKB/Swiss-Prot
      B2RAB0, O00194, Q9BZB6

    RNA

    1. XR_008485020.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O00194.4 GenPept UniProtKB/Swiss-Prot:O00194

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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