U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    GRK4 G protein-coupled receptor kinase 4 [ Homo sapiens (human) ]

    Gene ID: 2868, updated on 2-May-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    GRK4provided by HGNC
    Official Full Name
    G protein-coupled receptor kinase 4provided by HGNC
    Primary source
    HGNC:HGNC:4543
    See related
    Ensembl:ENSG00000125388 MIM:137026; AllianceGenome:HGNC:4543
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IT11; GPRK4; GRK4a; GPRK2L
    Summary
    This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating its deactivation. This gene has been linked to both genetic and acquired hypertension. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
    Expression
    Biased expression in testis (RPKM 14.6) and brain (RPKM 0.7) See more
    Orthologs
    mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    4p16.3
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (2963571..3040760)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (2962247..3039448)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (2965298..3042487)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21199 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21200 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21201 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21202 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:2935265-2936132 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15193 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15194 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr4:2937390-2938589 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21204 Neighboring gene NOP14 antisense RNA 1 Neighboring gene major facilitator superfamily domain containing 10 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr4:2948362-2949561 Neighboring gene NOP14 nucleolar protein Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21205 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:2964791-2965324 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:2965325-2965858 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15196 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr4:3011160-3012359 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21206 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:3022951-3023451 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21208 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21209 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21210 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21211 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15197 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21212 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21213 Neighboring gene RNA, U6 small nuclear 204, pseudogene Neighboring gene HTT antisense RNA Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21214 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15198 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15199

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Comprehensive insights in GRK4 and hypertension: From mechanisms to potential therapeutics. Yang J, et al. Pharmacol Ther, 2022 Nov. PMID 35487286, Free PMC Article
    2. Genetic variants of GRK4 influence circadian rhythm of blood pressure and response to candesartan in hypertensive patients. Cao N, et al. Clin Exp Hypertens, 2021 Oct 3. PMID 33899625, Free PMC Article
    3. The role of G protein-coupled receptor kinase 4 in cardiomyocyte injury after myocardial infarction. Li L, et al. Eur Heart J, 2021 Apr 7. PMID 33280021, Free PMC Article
    4. Renal Dopamine Receptors and Oxidative Stress: Role in Hypertension. Yang J, et al. Antioxid Redox Signal, 2021 Mar 20. PMID 32349533, Free PMC Article
    5. Proteomics analysis of G protein-coupled receptor kinase 4-inhibited cellular growth of HEK293 cells. Luo Y, et al. J Proteomics, 2019 Sep 15. PMID 31349021

    See all (73) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Downregulation of G protein-coupled receptor kinase 4 protects against kidney ischemia-reperfusion injury.
      Title: Downregulation of G protein-coupled receptor kinase 4 protects against kidney ischemia-reperfusion injury.
    2. Comprehensive insights in GRK4 and hypertension: From mechanisms to potential therapeutics.
      Title: Comprehensive insights in GRK4 and hypertension: From mechanisms to potential therapeutics.
    3. Genetic variants of GRK4 influence circadian rhythm of blood pressure and response to candesartan in hypertensive patients.
      Title: Genetic variants of GRK4 influence circadian rhythm of blood pressure and response to candesartan in hypertensive patients.
    4. Associations of SUCNR1, GRK4, CAMK1D gene polymorphisms and the susceptibility of type 2 diabetes mellitus and essential hypertension in a northern Chinese Han population.
      Title: Associations of SUCNR1, GRK4, CAMK1D gene polymorphisms and the susceptibility of type 2 diabetes mellitus and essential hypertension in a northern Chinese Han population.
    5. Renal Dopamine Receptors and Oxidative Stress: Role in Hypertension.
      Title: Renal Dopamine Receptors and Oxidative Stress: Role in Hypertension.
    6. Targeted capture sequencing identifies genetic variations of GRK4 and RDH8 in Han Chinese with essential hypertension in Xinjiang.
      Title: Targeted capture sequencing identifies genetic variations of GRK4 and RDH8 in Han Chinese with essential hypertension in Xinjiang.
    7. The role of G protein-coupled receptor kinase 4 in cardiomyocyte injury after myocardial infarction.
      Title: The role of G protein-coupled receptor kinase 4 in cardiomyocyte injury after myocardial infarction.
    8. Proteomics analysis of G protein-coupled receptor kinase 4-inhibited cellular growth of HEK293 cells.
      Title: Proteomics analysis of G protein-coupled receptor kinase 4-inhibited cellular growth of HEK293 cells.
    9. GRK4 gene variants in humans (GRK4 A>65L, A>142V, and A>486V) are associated with Hypertension in several but not all ethnic groups. GRK4 gene variants impair the function of D1R and D3R and abet the function of AT1R. These lead to enhancement of renal sodium reabsorption and impaired ability to excrete a sodium load that eventually leads to hypertension. Acknowledgments
      Title: Gastrorenal Axis.
    10. On normal salt diet, renal CuZnSOD and ECSOD proteins were similar but renal MnSOD was lower in hGRK4g486V than Non-T mice and remained low on high salt diet. hGRK4gammawild-type mice were normotensive and hGRK4g142V mice were hypertensive but both were salt-resistant and in normal redox balance. Chronic tempol treatment partially prevented the salt-sensitivity of hGRK4g486V mice.
      Title: Increased renal oxidative stress in salt-sensitive human GRK4γ486V transgenic mice.
    Submit: New GeneRIF Correction See all GeneRIFs (46)

    Phenotypes

    Go to the top of the page Help

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

    Go to the top of the page Help

    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables rhodopsin kinase activity TAS
    Traceable Author Statement
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in receptor internalization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of opsin-mediated signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    involved_in regulation of signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in photoreceptor disc membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    G protein-coupled receptor kinase 4
    Names
    G protein-coupled receptor kinase 2-like
    NP_001004056.1
    NP_001004057.1
    NP_001337102.1
    NP_005298.2
    NP_892027.2
    XP_005248019.1
    XP_011511749.1
    XP_011511750.1
    XP_011511751.1
    XP_011511752.1
    XP_011511753.1
    XP_011511754.1
    XP_011511755.1
    XP_011511756.1
    XP_011511757.1
    XP_011511758.1
    XP_011511759.1
    XP_016863541.1
    XP_016863542.1
    XP_016863543.1
    XP_016863544.1
    XP_016863545.1
    XP_047306080.1
    XP_047306081.1
    XP_047306082.1
    XP_047306083.1
    XP_047306084.1
    XP_054205768.1
    XP_054205769.1
    XP_054205770.1
    XP_054205771.1
    XP_054205772.1
    XP_054205773.1
    XP_054205774.1
    XP_054205775.1
    XP_054205776.1
    XP_054205777.1
    XP_054205778.1
    XP_054205779.1
    XP_054205780.1
    XP_054205781.1
    XP_054205782.1
    XP_054205783.1
    XP_054205784.1
    XP_054205785.1
    XP_054205786.1
    XP_054205787.1
    XP_054205788.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029102.1 RefSeqGene

      Range
      4956..82145
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001004056.2 → NP_001004056.1  G protein-coupled receptor kinase 4 isoform beta

      See identical proteins and their annotated locations for NP_001004056.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (beta) has the same N- and C-termini but is shorter compared to isoform alpha.
      Source sequence(s)
      AL390065, BC027597, BI465220, BM725978, U33054
      Consensus CDS
      CCDS47002.1
      UniProtKB/TrEMBL
      A8K8M5
      Related
      ENSP00000264764.8, ENST00000345167.10
      Conserved Domains (3) summary
      cd05631
      Location:154 → 438
      STKc_GRK4; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 4
      smart00220
      Location:155 → 417
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl02565
      Location:20 → 152
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    2. NM_001004057.2 → NP_001004057.1  G protein-coupled receptor kinase 4 isoform gamma

      See identical proteins and their annotated locations for NP_001004057.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (gamma) has the same N- and C-termini but is shorter compared to isoform alpha.
      Source sequence(s)
      AL390065, BC027597, BI465220, BM725978
      Consensus CDS
      CCDS33947.1
      UniProtKB/TrEMBL
      A8K8M5
      Related
      ENSP00000427445.1, ENST00000504933.1
      Conserved Domains (3) summary
      cd05631
      Location:186 → 470
      STKc_GRK4; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 4
      smart00220
      Location:187 → 449
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl02565
      Location:52 → 184
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    3. NM_001350173.2 → NP_001337102.1  G protein-coupled receptor kinase 4 isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at an alternate start codon, compared to variant 1. It encodes isoform 5, which has a shorter and distinct N-terminus, compared to isoform alpha.
      Source sequence(s)
      AK223581, AK292390, AL390065, BI792406, N23898, X97881
      Conserved Domains (1) summary
      cl21453
      Location:5 → 276
      PKc_like; Protein Kinases, catalytic domain

    4. NM_005307.3 → NP_005298.2  G protein-coupled receptor kinase 4 isoform delta

      See identical proteins and their annotated locations for NP_005298.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (delta) has the same N- and C-termini but is shorter compared to isoform alpha.
      Source sequence(s)
      AK223581, AL390065, X97879
      Consensus CDS
      CCDS68656.1
      UniProtKB/TrEMBL
      A8K8M5
      Related
      ENSP00000381128.4, ENST00000398051.8
      Conserved Domains (3) summary
      cd05631
      Location:154 → 438
      STKc_GRK4; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 4
      smart00220
      Location:155 → 417
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl02565
      Location:20 → 152
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    5. NM_182982.3 → NP_892027.2  G protein-coupled receptor kinase 4 isoform alpha

      See identical proteins and their annotated locations for NP_892027.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (alpha).
      Source sequence(s)
      AL390065, BC027597, BI465220, BM725978, U33054
      Consensus CDS
      CCDS33946.1
      UniProtKB/Swiss-Prot
      O00641, O00642, P32298, Q13293, Q13294, Q13295, Q14453, Q14725, Q15313, Q15314, Q15315, Q15316, Q17RH6, Q53EQ8
      UniProtKB/TrEMBL
      A8K8M5
      Related
      ENSP00000381129.4, ENST00000398052.9
      Conserved Domains (3) summary
      cd05631
      Location:186 → 470
      STKc_GRK4; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 4
      smart00220
      Location:187 → 449
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl02565
      Location:52 → 184
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      2963571..3040760
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011513447.3 → XP_011511749.1  G protein-coupled receptor kinase 4 isoform X1

      UniProtKB/TrEMBL
      A8K8M5
      Conserved Domains (3) summary
      cd05631
      Location:186 → 509
      STKc_GRK4; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 4
      smart00220
      Location:187 → 488
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl02565
      Location:52 → 184
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    2. XM_011513450.3 → XP_011511752.1  G protein-coupled receptor kinase 4 isoform X6

      UniProtKB/TrEMBL
      A8K8M5
      Conserved Domains (3) summary
      cd05631
      Location:186 → 509
      STKc_GRK4; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 4
      smart00220
      Location:187 → 488
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl02565
      Location:52 → 184
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    3. XM_011513453.3 → XP_011511755.1  G protein-coupled receptor kinase 4 isoform X10

      UniProtKB/TrEMBL
      A8K8M5
      Conserved Domains (3) summary
      smart00220
      Location:187 → 488
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl02565
      Location:52 → 184
      RGS; Regulator of G protein signaling (RGS) domain superfamily
      cl21453
      Location:186 → 508
      PKc_like; Protein Kinases, catalytic domain

    4. XM_011513451.3 → XP_011511753.1  G protein-coupled receptor kinase 4 isoform X7

      UniProtKB/TrEMBL
      A8K8M5
      Conserved Domains (3) summary
      smart00220
      Location:187 → 462
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl02565
      Location:52 → 184
      RGS; Regulator of G protein signaling (RGS) domain superfamily
      cl21453
      Location:186 → 470
      PKc_like; Protein Kinases, catalytic domain

    5. XM_011513454.3 → XP_011511756.1  G protein-coupled receptor kinase 4 isoform X9

      UniProtKB/TrEMBL
      A8K8M5
      Conserved Domains (2) summary
      cl02565
      Location:52 → 184
      RGS; Regulator of G protein signaling (RGS) domain superfamily
      cl21453
      Location:186 → 470
      PKc_like; Protein Kinases, catalytic domain

    6. XM_011513455.3 → XP_011511757.1  G protein-coupled receptor kinase 4 isoform X12

      Conserved Domains (3) summary
      smart00220
      Location:187 → 471
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl02565
      Location:52 → 184
      RGS; Regulator of G protein signaling (RGS) domain superfamily
      cl21453
      Location:186 → 472
      PKc_like; Protein Kinases, catalytic domain

    7. XM_017008053.2 → XP_016863542.1  G protein-coupled receptor kinase 4 isoform X4

      UniProtKB/TrEMBL
      A8K8M5

    8. XM_011513456.3 → XP_011511758.1  G protein-coupled receptor kinase 4 isoform X15

      Conserved Domains (2) summary
      cl02565
      Location:52 → 184
      RGS; Regulator of G protein signaling (RGS) domain superfamily
      cl21453
      Location:186 → 363
      PKc_like; Protein Kinases, catalytic domain

    9. XM_017008054.2 → XP_016863543.1  G protein-coupled receptor kinase 4 isoform X11

      UniProtKB/TrEMBL
      A8K8M5

    10. XM_017008056.2 → XP_016863545.1  G protein-coupled receptor kinase 4 isoform X14

    11. XM_017008052.2 → XP_016863541.1  G protein-coupled receptor kinase 4 isoform X3

      UniProtKB/TrEMBL
      A8K8M5

    12. XM_011513449.3 → XP_011511751.1  G protein-coupled receptor kinase 4 isoform X5

      UniProtKB/TrEMBL
      A8K8M5
      Conserved Domains (3) summary
      cd05631
      Location:154 → 477
      STKc_GRK4; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 4
      smart00220
      Location:155 → 456
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl02565
      Location:20 → 152
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    13. XM_017008055.2 → XP_016863544.1  G protein-coupled receptor kinase 4 isoform X13

    14. XM_005247962.4 → XP_005248019.1  G protein-coupled receptor kinase 4 isoform X17

      See identical proteins and their annotated locations for XP_005248019.1

      Conserved Domains (2) summary
      smart00220
      Location:20 → 238
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:1 → 259
      PKc_like; Protein Kinases, catalytic domain

    15. XM_011513452.3 → XP_011511754.1  G protein-coupled receptor kinase 4 isoform X8

      UniProtKB/TrEMBL
      A8K8M5
      Conserved Domains (2) summary
      cd08750
      Location:52 → 184
      RGS_GRK4; Regulator of G protein signaling domain (RGS) found in G protein-coupled receptor kinase 4 (GRK4)
      cl21453
      Location:186 → 470
      PKc_like; Protein Kinases, catalytic domain

    16. XM_011513448.3 → XP_011511750.1  G protein-coupled receptor kinase 4 isoform X2

      UniProtKB/TrEMBL
      A8K8M5
      Conserved Domains (2) summary
      cd05631
      Location:186 → 509
      STKc_GRK4; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 4
      cd08750
      Location:52 → 184
      RGS_GRK4; Regulator of G protein signaling domain (RGS) found in G protein-coupled receptor kinase 4 (GRK4)

    17. XM_047450128.1 → XP_047306084.1  G protein-coupled receptor kinase 4 isoform X19

    18. XM_047450127.1 → XP_047306083.1  G protein-coupled receptor kinase 4 isoform X19

    19. XM_011513457.3 → XP_011511759.1  G protein-coupled receptor kinase 4 isoform X18

      Conserved Domains (2) summary
      cl02565
      Location:52 → 184
      RGS; Regulator of G protein signaling (RGS) domain superfamily
      cl21453
      Location:186 → 286
      PKc_like; Protein Kinases, catalytic domain

    20. XM_047450125.1 → XP_047306081.1  G protein-coupled receptor kinase 4 isoform X17

    21. XM_047450126.1 → XP_047306082.1  G protein-coupled receptor kinase 4 isoform X17

    22. XM_047450124.1 → XP_047306080.1  G protein-coupled receptor kinase 4 isoform X16

    RNA

    1. XR_924941.3 RNA Sequence

    2. XR_001741210.2 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      2962247..3039448
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054349793.1 → XP_054205768.1  G protein-coupled receptor kinase 4 isoform X1

    2. XM_054349798.1 → XP_054205773.1  G protein-coupled receptor kinase 4 isoform X6

    3. XM_054349802.1 → XP_054205777.1  G protein-coupled receptor kinase 4 isoform X10

    4. XM_054349799.1 → XP_054205774.1  G protein-coupled receptor kinase 4 isoform X7

    5. XM_054349801.1 → XP_054205776.1  G protein-coupled receptor kinase 4 isoform X9

    6. XM_054349804.1 → XP_054205779.1  G protein-coupled receptor kinase 4 isoform X12

    7. XM_054349796.1 → XP_054205771.1  G protein-coupled receptor kinase 4 isoform X4

    8. XM_054349807.1 → XP_054205782.1  G protein-coupled receptor kinase 4 isoform X15

    9. XM_054349803.1 → XP_054205778.1  G protein-coupled receptor kinase 4 isoform X11

    10. XM_054349806.1 → XP_054205781.1  G protein-coupled receptor kinase 4 isoform X14

    11. XM_054349795.1 → XP_054205770.1  G protein-coupled receptor kinase 4 isoform X3

    12. XM_054349797.1 → XP_054205772.1  G protein-coupled receptor kinase 4 isoform X5

    13. XM_054349805.1 → XP_054205780.1  G protein-coupled receptor kinase 4 isoform X13

    14. XM_054349810.1 → XP_054205785.1  G protein-coupled receptor kinase 4 isoform X17

    15. XM_054349800.1 → XP_054205775.1  G protein-coupled receptor kinase 4 isoform X8

    16. XM_054349794.1 → XP_054205769.1  G protein-coupled receptor kinase 4 isoform X2

    17. XM_054349813.1 → XP_054205788.1  G protein-coupled receptor kinase 4 isoform X19

    18. XM_054349812.1 → XP_054205787.1  G protein-coupled receptor kinase 4 isoform X18

    19. XM_054349809.1 → XP_054205784.1  G protein-coupled receptor kinase 4 isoform X17

    20. XM_054349811.1 → XP_054205786.1  G protein-coupled receptor kinase 4 isoform X17

    21. XM_054349808.1 → XP_054205783.1  G protein-coupled receptor kinase 4 isoform X16

    RNA

    1. XR_008486968.1 RNA Sequence

    2. XR_008486969.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32298.3 GenPept UniProtKB/Swiss-Prot:P32298

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous