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    USP24 ubiquitin specific peptidase 24 [ Homo sapiens (human) ]

    Gene ID: 23358, updated on 5-May-2024

    Summary

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    Official Symbol
    USP24provided by HGNC
    Official Full Name
    ubiquitin specific peptidase 24provided by HGNC
    Primary source
    HGNC:HGNC:12623
    See related
    Ensembl:ENSG00000162402 MIM:610569; AllianceGenome:HGNC:12623
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP24 belongs to a large family of cysteine proteases that function as deubiquitinating enzymes (Quesada et al., 2004 [PubMed 14715245]).[supplied by OMIM, Mar 2008]
    Expression
    Ubiquitous expression in bone marrow (RPKM 9.9), lymph node (RPKM 9.7) and 25 other tissues See more
    Orthologs
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    Genomic context

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    Location:
    1p32.3
    Exon count:
    71
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (55066359..55215364, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (54947243..55096207, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (55532032..55681037, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1070 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:55466287-55466787 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:55484247-55484747 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:55488329-55488955 Neighboring gene barttin CLCNK type accessory subunit beta Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:55493259-55493762 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:55493763-55494266 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:55494267-55494770 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:55501658-55501847 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:55509121-55509622 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:55509623-55510122 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:55514655-55515210 Neighboring gene proprotein convertase subtilisin/kexin type 9 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1071 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 928 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 929 Neighboring gene uncharacterized LOC100507634 Neighboring gene MIR4422 host gene Neighboring gene glycogenin 1 pseudogene 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Variants of ubiquitin-specific peptidase 24 play a crucial role in lung cancer malignancy. Wang YC, et al. Oncogene, 2016 Jul 14. PMID 26568301
    2. Transcriptional regulation of human USP24 gene expression by NF-kappa B. Wang K, et al. J Neurochem, 2014 Mar. PMID 24286619
    3. Ubiquitin-specific protease 24 promotes EV71 infection by restricting K63-linked polyubiquitination of TBK1. Zang L, et al. Virol Sin, 2023 Feb. PMID 36334706, Free PMC Article
    4. USP24 Is a Cancer-Associated Ubiquitin Hydrolase, Novel Tumor Suppressor, and Chromosome Instability Gene Deleted in Neuroblastoma. Bedekovics T, et al. Cancer Res, 2021 Mar 1. PMID 33355202
    5. USP24 induces IL-6 in tumor-associated microenvironment by stabilizing p300 and β-TrCP and promotes cancer malignancy. Wang YC, et al. Nat Commun, 2018 Sep 28. PMID 30266897, Free PMC Article

    See all (83) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MiR-21-5p promotes sorafenib resistance and hepatocellular carcinoma progression by regulating SIRT7 ubiquitination through USP24.
      Title: MiR-21-5p promotes sorafenib resistance and hepatocellular carcinoma progression by regulating SIRT7 ubiquitination through USP24.
    2. USP24-GSDMB complex promotes bladder cancer proliferation via activation of the STAT3 pathway.
      Title: USP24-GSDMB complex promotes bladder cancer proliferation via activation of the STAT3 pathway.
    3. USP24 Is a Cancer-Associated Ubiquitin Hydrolase, Novel Tumor Suppressor, and Chromosome Instability Gene Deleted in Neuroblastoma.
      Title: USP24 Is a Cancer-Associated Ubiquitin Hydrolase, Novel Tumor Suppressor, and Chromosome Instability Gene Deleted in Neuroblastoma.
    4. USP24 stabilizes bromodomain containing proteins to promote lung cancer malignancy.
      Title: USP24 stabilizes bromodomain containing proteins to promote lung cancer malignancy.
    5. The PARK10 gene USP24 is a negative regulator of autophagy and ULK1 protein stability.
      Title: The PARK10 gene USP24 is a negative regulator of autophagy and ULK1 protein stability.
    6. Data indicate that ubiquitin specific peptidase 24 (USP24) promotes Interleukin-6 (IL-6) expression, which might be beneficial for cancer therapy.
      Title: USP24 induces IL-6 in tumor-associated microenvironment by stabilizing p300 and β-TrCP and promotes cancer malignancy.
    7. USP24 level was decreased during the early stage of cancer and the mitotic stage of the cell cycle to regulate its substrates p300, Bax, E2F4 and securin, resulting in decreased cell apoptosis and increased cell cycle progression and, thus, cancer formation.
      Title: EGF-mediated inhibition of ubiquitin-specific peptidase 24 expression has a crucial role in tumorigenesis.
    8. Data show that ubiquitin-specific peptidase 24 (USP24) is highly expressed in cell lines with enhanced malignancy and in late-stage lung cancer clinical samples.
      Title: Variants of ubiquitin-specific peptidase 24 play a crucial role in lung cancer malignancy.
    9. USP24 deubiquitinase regulates the DNA damage response by directly targeting the p53 tumor suppressor.
      Title: The deubiquitinating enzyme USP24 is a regulator of the UV damage response.
    10. the novel compound EOAI3402143 dose-dependently inhibited Usp9x and Usp24 activity, increased tumor cell apoptosis, and fully blocked or regressed myeloma tumors in mice.
      Title: Targeting deubiquitinase activity with a novel small-molecule inhibitor as therapy for B-cell malignancies.
    Submit: New GeneRIF Correction See all GeneRIFs (17)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide characterization of shared and distinct genetic components that influence blood lipid levels in ethnically diverse human populations.
    EBI GWAS Catalog
    Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ31309, KIAA1057

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type deubiquitinase activity TAS
    Traceable Author Statement
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein deubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 24
    Names
    deubiquitinating enzyme 24
    ubiquitin specific protease 24
    ubiquitin thioesterase 24
    ubiquitin thiolesterase 24
    ubiquitin-specific processing protease 24
    NP_056121.2
    XP_005270747.1
    XP_016856320.1
    XP_016856321.1
    XP_016856325.1
    XP_016856326.1
    XP_047272480.1
    XP_047272481.1
    XP_047272482.1
    XP_047272483.1
    XP_054191582.1
    XP_054191583.1
    XP_054191584.1
    XP_054191585.1
    XP_054191586.1
    XP_054191587.1
    XP_054191588.1
    XP_054191589.1
    XP_054191590.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_015306.3 → NP_056121.2  ubiquitin carboxyl-terminal hydrolase 24

      See identical proteins and their annotated locations for NP_056121.2

      Status: VALIDATED

      Source sequence(s)
      AC091609
      Consensus CDS
      CCDS44154.2
      UniProtKB/Swiss-Prot
      Q6ZSY2, Q8N2Y4, Q9NXD1, Q9UPU5
      UniProtKB/TrEMBL
      A0A0U1RQI9
      Related
      ENSP00000294383.5, ENST00000294383.7
      Conserved Domains (3) summary
      cd02659
      Location:1687 → 2044
      peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cd14286
      Location:6 → 42
      UBA_UBP24; UBA domain found in ubiquitin carboxyl-terminal hydrolase 24 (UBP24) and similar proteins
      pfam00443
      Location:1689 → 2039
      UCH; Ubiquitin carboxyl-terminal hydrolase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      55066359..55215364 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047416524.1 → XP_047272480.1  ubiquitin carboxyl-terminal hydrolase 24 isoform X3

    2. XM_017000832.2 → XP_016856321.1  ubiquitin carboxyl-terminal hydrolase 24 isoform X2

      UniProtKB/TrEMBL
      A0A0U1RQI9

    3. XM_017000831.2 → XP_016856320.1  ubiquitin carboxyl-terminal hydrolase 24 isoform X1

      UniProtKB/TrEMBL
      A0A0U1RQI9

    4. XM_005270690.4 → XP_005270747.1  ubiquitin carboxyl-terminal hydrolase 24 isoform X4

      Conserved Domains (2) summary
      cd02659
      Location:1092 → 1449
      peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam00443
      Location:1094 → 1444
      UCH; Ubiquitin carboxyl-terminal hydrolase

    5. XM_047416525.1 → XP_047272481.1  ubiquitin carboxyl-terminal hydrolase 24 isoform X5

    6. XM_047416526.1 → XP_047272482.1  ubiquitin carboxyl-terminal hydrolase 24 isoform X6

    7. XM_017000836.2 → XP_016856325.1  ubiquitin carboxyl-terminal hydrolase 24 isoform X7

    8. XM_047416527.1 → XP_047272483.1  ubiquitin carboxyl-terminal hydrolase 24 isoform X8

    9. XM_017000837.2 → XP_016856326.1  ubiquitin carboxyl-terminal hydrolase 24 isoform X9

    RNA

    1. XR_001737080.2 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      54947243..55096207 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054335609.1 → XP_054191584.1  ubiquitin carboxyl-terminal hydrolase 24 isoform X3

    2. XM_054335608.1 → XP_054191583.1  ubiquitin carboxyl-terminal hydrolase 24 isoform X2

    3. XM_054335607.1 → XP_054191582.1  ubiquitin carboxyl-terminal hydrolase 24 isoform X1

    4. XM_054335610.1 → XP_054191585.1  ubiquitin carboxyl-terminal hydrolase 24 isoform X4

    5. XM_054335611.1 → XP_054191586.1  ubiquitin carboxyl-terminal hydrolase 24 isoform X5

    6. XM_054335612.1 → XP_054191587.1  ubiquitin carboxyl-terminal hydrolase 24 isoform X6

    7. XM_054335613.1 → XP_054191588.1  ubiquitin carboxyl-terminal hydrolase 24 isoform X7

    8. XM_054335614.1 → XP_054191589.1  ubiquitin carboxyl-terminal hydrolase 24 isoform X8

    9. XM_054335615.1 → XP_054191590.1  ubiquitin carboxyl-terminal hydrolase 24 isoform X9

    RNA

    1. XR_008485967.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9UPU5.3 GenPept UniProtKB/Swiss-Prot:Q9UPU5

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