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    VAV1 vav guanine nucleotide exchange factor 1 [ Bos taurus (cattle) ]

    Gene ID: 617345, updated on 3-Apr-2024

    Summary

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    Official Symbol
    VAV1provided by VGNC
    Official Full Name
    vav guanine nucleotide exchange factor 1provided by VGNC
    Primary source
    VGNC:VGNC:36772
    See related
    Ensembl:ENSBTAG00000039160
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See VAV1 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 7 NC_037334.1 (17664509..17728397, complement)

    Chromosome 7 - NC_037334.1Genomic Context describing neighboring genes Neighboring gene adhesion G protein-coupled receptor E4 Neighboring gene U7 small nuclear RNA Neighboring gene adhesion G protein-coupled receptor E1 Neighboring gene SH2 domain containing 3A Neighboring gene thyroid hormone receptor interactor 10 Neighboring gene microRNA mir-6535

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037334.1 Chromosome 7 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell migration IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    proto-oncogene vav
    Names
    vav 1 guanine nucleotide exchange factor
    vav 1 oncogene

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001078074.1 → NP_001071542.1  proto-oncogene vav

      See identical proteins and their annotated locations for NP_001071542.1

      Status: PROVISIONAL

      Source sequence(s)
      BC123646
      UniProtKB/Swiss-Prot
      Q08DN7
      UniProtKB/TrEMBL
      F1MSK3
      Related
      ENSBTAP00000050922.3, ENSBTAT00000056825.4
      Conserved Domains (8) summary
      cd10405
      Location:664 → 766
      SH2_Vav1; Src homology 2 (SH2) domain found in the Vav1 proteins
      cd11976
      Location:785 → 838
      SH3_VAV1_2; C-terminal (or second) Src homology 3 domain of VAV1 protein
      cd11979
      Location:595 → 657
      SH3_VAV1_1; First Src homology 3 domain of VAV1 protein
      cd00160
      Location:194 → 370
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01223
      Location:384 → 507
      PH_Vav; Vav pleckstrin homology (PH) domain
      pfam00130
      Location:515 → 566
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam00169
      Location:402 → 503
      PH; PH domain
      pfam00307
      Location:2 → 115
      CH; Calponin homology (CH) domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037334.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      17664509..17728397 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059888402.1 → XP_059744385.1  proto-oncogene vav isoform X1

      Related
      ENSBTAP00000089802.1, ENSBTAT00000090348.1

    2. XM_059888405.1 → XP_059744388.1  proto-oncogene vav isoform X4

    3. XM_059888404.1 → XP_059744387.1  proto-oncogene vav isoform X3

    4. XM_059888403.1 → XP_059744386.1  proto-oncogene vav isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08DN7.1 GenPept UniProtKB/Swiss-Prot:Q08DN7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.