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    PCSK2 proprotein convertase subtilisin/kexin type 2 [ Sus scrofa (pig) ]

    Gene ID: 445533, updated on 5-Mar-2024

    Summary

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    Official Symbol
    PCSK2provided by VGNC
    Official Full Name
    proprotein convertase subtilisin/kexin type 2provided by VGNC
    Primary source
    VGNC:VGNC:96471
    See related
    Ensembl:ENSSSCG00000007083
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
    Also known as
    PC2
    Expression
    Biased expression in mixtures (RPKM 2.2), spleen (RPKM 0.4) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See PCSK2 in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) 17 NC_010459.5 (25681424..25920690)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) 17 NC_010459.4 (29095048..29329854)

    Chromosome 17 - NC_010459.5Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102159962 Neighboring gene small nuclear ribonucleoprotein polypeptide B2 Neighboring gene otoraplin Neighboring gene beaded filament structural protein 1 Neighboring gene destrin, actin depolymerizing factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Transcriptome data used for gene annotation
    • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
    • BioProject: PRJNA311523
    • Publication: PMID 27646534
    • Analysis date: Thu Dec 14 17:10:49 2017

    Bibliography

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    Related articles in PubMed

    1. The cDNA structure of the porcine pro-hormone convertase PC2 and the comparative processing by PC1 and PC2 of the N-terminal glycopeptide segment of porcine POMC. Seidah NG, et al. FEBS Lett, 1992 Oct 5. PMID 1397279

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein processing IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in trans-Golgi network IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    neuroendocrine convertase 2
    Names
    KEX2-like endoprotease 2
    NEC 2
    pro-hormone convertase
    prohormone convertase 2
    proprotein convertase 2
    NP_001004044.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004044.1 → NP_001004044.1  neuroendocrine convertase 2 precursor

      See identical proteins and their annotated locations for NP_001004044.1

      Status: PROVISIONAL

      Source sequence(s)
      X68603
      UniProtKB/Swiss-Prot
      Q03333
      UniProtKB/TrEMBL
      A0A4X1UY00, A0A5G2QNM3, A0A8D1YT65
      Related
      ENSSSCP00000007546.4, ENSSSCT00000007755.4
      Conserved Domains (4) summary
      cd04059
      Location:122 → 418
      Peptidases_S8_Protein_convertases_Kexins_Furin-like; Peptidase S8 family domain in Protein convertases
      pfam00082
      Location:158 → 435
      Peptidase_S8; Subtilase family
      pfam01483
      Location:504 → 591
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:33 → 109
      S8_pro-domain; Peptidase S8 pro-domain

    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010459.5 Reference Sscrofa11.1 Primary Assembly

      Range
      25681424..25920690
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03333.1 GenPept UniProtKB/Swiss-Prot:Q03333

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