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    OR52N4 olfactory receptor family 52 subfamily N member 4 [ Homo sapiens (human) ]

    Gene ID: 390072, updated on 3-Apr-2024

    Summary

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    Official Symbol
    OR52N4provided by HGNC
    Official Full Name
    olfactory receptor family 52 subfamily N member 4provided by HGNC
    Primary source
    HGNC:HGNC:15230
    See related
    Ensembl:ENSG00000181074 AllianceGenome:HGNC:15230
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OR11-64
    Summary
    Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
    Annotation information
    Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene.
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    all
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    Genomic context

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    See OR52N4 in Genome Data Viewer
    Location:
    11p15.4
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (5726472..5755958)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (5784322..5813802)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (5775473..5777188)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:5711125-5712324 Neighboring gene uncharacterized LOC124902620 Neighboring gene tripartite motif containing 22 Neighboring gene olfactory receptor family 52 subfamily U member 1 pseudogene Neighboring gene MPRA-validated peak1182 silencer Neighboring gene olfactory receptor family 52 subfamily P member 1 (gene/pseudogene) Neighboring gene olfactory receptor family 56 subfamily B member 1 Neighboring gene olfactory receptor family 56 subfamily B member 2 pseudogene Neighboring gene olfactory receptor family 52 subfamily N member 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The human olfactory receptor gene family. Malnic B, et al. Proc Natl Acad Sci U S A, 2004 Feb 24. PMID 14983052, Free PMC Article
    2. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Huttlin EL, et al. Cell, 2021 May 27. PMID 33961781, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables olfactory receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in detection of chemical stimulus involved in sensory perception of smell IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    olfactory receptor 52N4
    Names
    olfactory receptor OR11-64

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001005175.5 → NP_001005175.3  olfactory receptor 52N4

      See identical proteins and their annotated locations for NP_001005175.3

      Status: VALIDATED

      Source sequence(s)
      AC131574
      Consensus CDS
      CCDS44528.1
      UniProtKB/Swiss-Prot
      B2RNP8, Q6IF77, Q8NGI2
      UniProtKB/TrEMBL
      A0A126GVF0
      Related
      ENSP00000493338.1, ENST00000641350.2
      Conserved Domains (2) summary
      pfam00001
      Location:43 → 295
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:33 → 311
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      5726472..5755958
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017017711.3 → XP_016873200.1  olfactory receptor 52N4 isoform X1

      UniProtKB/Swiss-Prot
      B2RNP8, Q6IF77, Q8NGI2
      UniProtKB/TrEMBL
      A0A126GVF0
      Conserved Domains (2) summary
      pfam00001
      Location:43 → 295
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:33 → 311
      7tm_4; Olfactory receptor

    2. XM_017017713.3 → XP_016873202.1  olfactory receptor 52N4 isoform X1

      UniProtKB/Swiss-Prot
      B2RNP8, Q6IF77, Q8NGI2
      UniProtKB/TrEMBL
      A0A126GVF0
      Conserved Domains (2) summary
      pfam00001
      Location:43 → 295
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:33 → 311
      7tm_4; Olfactory receptor

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      5784322..5813802
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054368738.1 → XP_054224713.1  olfactory receptor 52N4 isoform X1

    2. XM_054368739.1 → XP_054224714.1  olfactory receptor 52N4 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8NGI2.2 GenPept UniProtKB/Swiss-Prot:Q8NGI2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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