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    trak1a trafficking protein, kinesin binding 1a [ Danio rerio (zebrafish) ]

    Gene ID: 100002689, updated on 27-Mar-2024

    Summary

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    Official Symbol
    trak1aprovided by ZNC
    Official Full Name
    trafficking protein, kinesin binding 1aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-100922-182
    See related
    Ensembl:ENSDARG00000041304 AllianceGenome:ZFIN:ZDB-GENE-100922-182
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    trak1; si:ch73-138e9.2
    Summary
    Predicted to enable GABA receptor binding activity and myosin binding activity. Predicted to be involved in several processes, including endosome to lysosome transport; mitochondrion distribution; and organelle transport along microtubule. Predicted to be located in early endosome. Predicted to be active in cytoplasmic vesicle; dendrite; and mitochondrion. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 68. Orthologous to human TRAK1 (trafficking kinesin protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See trak1a in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (5786766..5899641, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (5887140..6000000, complement)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene NADH:ubiquinone oxidoreductase subunit A3 Neighboring gene cholecystokinin a Neighboring gene unc-51 like kinase 4 Neighboring gene catenin (cadherin-associated protein), beta 1 Neighboring gene CKLF-like MARVEL transmembrane domain containing 8b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Zebrafish Trak proteins 1a and 2 localize to the mitochondria. Oonk KA, et al. MicroPubl Biol, 2020 Oct 16. PMID 33274332, Free PMC Article
    2. Systematic discovery of novel ciliary genes through functional genomics in the zebrafish. Choksi SP, et al. Development, 2014 Sep. PMID 25139857, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables GABA receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables myosin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in anterograde axonal transport of mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endosome to lysosome transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrion distribution IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neurogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein targeting IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle transport along microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    trafficking kinesin-binding protein 1
    Names
    trafficking protein, kinesin binding 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      5786766..5899641 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009292048.3 → XP_009290323.1  trafficking kinesin-binding protein 1 isoform X4

      UniProtKB/TrEMBL
      A0A8M3AQA5, E9QJ68
      Related
      ENSDARP00000115803.1, ENSDART00000136936.3
      Conserved Domains (4) summary
      pfam04871
      Location:108 → 206
      Uso1_p115_C; Uso1 / p115 like vesicle tethering protein, C terminal region
      pfam12448
      Location:321 → 477
      Milton; Kinesin associated protein
      pfam14662
      Location:21 → 237
      KASH_CCD; Coiled-coil region of CCDC155 or KASH
      cl21478
      Location:177 → 249
      ATP-synt_B; ATP synthase B/B' CF(0)

    2. XM_009292045.3 → XP_009290320.1  trafficking kinesin-binding protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8M3B1F5
      Conserved Domains (4) summary
      pfam04849
      Location:21 → 324
      HAP1_N; HAP1 N-terminal conserved region
      pfam04871
      Location:183 → 281
      Uso1_p115_C; Uso1 / p115 like vesicle tethering protein, C terminal region
      pfam12448
      Location:396 → 552
      Milton; Kinesin associated protein
      cl21478
      Location:252 → 324
      ATP-synt_B; ATP synthase B/B' CF(0)

    3. XM_009292047.3 → XP_009290322.1  trafficking kinesin-binding protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A8M3AT45
      Conserved Domains (4) summary
      pfam04871
      Location:138 → 236
      Uso1_p115_C; Uso1 / p115 like vesicle tethering protein, C terminal region
      pfam12448
      Location:351 → 507
      Milton; Kinesin associated protein
      pfam14662
      Location:51 → 267
      KASH_CCD; Coiled-coil region of CCDC155 or KASH
      cl21478
      Location:207 → 279
      ATP-synt_B; ATP synthase B/B' CF(0)

    4. XM_009292046.3 → XP_009290321.1  trafficking kinesin-binding protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A8M3AIV7
      Conserved Domains (4) summary
      pfam04871
      Location:168 → 266
      Uso1_p115_C; Uso1 / p115 like vesicle tethering protein, C terminal region
      pfam12448
      Location:381 → 537
      Milton; Kinesin associated protein
      pfam14662
      Location:81 → 297
      KASH_CCD; Coiled-coil region of CCDC155 or KASH
      cl21478
      Location:237 → 309
      ATP-synt_B; ATP synthase B/B' CF(0)

    5. XM_021466845.1 → XP_021322520.1  trafficking kinesin-binding protein 1 isoform X5

      UniProtKB/TrEMBL
      A0A8M9PMV3
      Conserved Domains (2) summary
      pfam04849
      Location:21 → 324
      HAP1_N; HAP1 N-terminal conserved region
      pfam12448
      Location:388 → 552
      Milton; Kinesin associated protein

    6. XM_009292053.3 → XP_009290328.1  trafficking kinesin-binding protein 1 isoform X6

      UniProtKB/TrEMBL
      A0A8M3B1F9
      Related
      ENSDARP00000080113.6, ENSDART00000085678.6
      Conserved Domains (2) summary
      pfam04849
      Location:21 → 324
      HAP1_N; HAP1 N-terminal conserved region
      pfam12448
      Location:396 → 552
      Milton; Kinesin associated protein

    RNA

    1. XR_002455744.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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