Lung epithelium cell line response to Influenza A virus (H3N2) non-structural 1 gene mutations
Summary:
Analysis of A549 cells infected with H3N2 influenza isolate A/Hong Kong/1/1968 (HK-wt) or recombinant HK NS1 mutants. NS1 is a multifunctional virulence factor. These results, together with those from GDS4998, provide insight into molecular effects of NS1 mutation on human versus mouse host cells.
GPL6244:
[HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [transcript (gene) version]
Citation:
Dankar SK, Miranda E, Forbes NE, Pelchat M et al. Influenza A/Hong Kong/156/1997(H5N1) virus NS1 gene mutations F103L and M106I both increase IFN antagonism, virulence and cytoplasmic localization but differ in binding to RIG-I and CPSF30. Virol J 2013 Jul 25;10:243. PMID: 23886034
