Small-molecule DOT1L inhibitor EPZ004777 effect on mixed lineage leukemia cells: time course
Summary:
Temporal analysis of mixed lineage leukemia (MLL)-rearranged cell lines MV4-11 and MOLM-13 treated with EPZ004777, a potent inhibitor of DOT1L histone methyl transferase. EPZ004777 induces differentiation and apoptosis in MLL-rearranged cells. Results provide insight into role of DOT1L in MLL cells.
GPL570:
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Citation:
Daigle SR, Olhava EJ, Therkelsen CA, Majer CR et al. Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor. Cancer Cell 2011 Jul 12;20(1):53-65. PMID: 21741596
