Androgen response element specific DNA-binding polyamide effect on dihydrotestoterone-stimulated prostate cell line
Summary:
Analysis of DHT-stimulated LNCaP prostate cells treated with an androgen response (AR) element (ARE) specific DNA binding polyamide. Polyamide designed to target the sequence 5'-WGWWCW-3' and disrupt AR-mediated gene expression. Effects of the synthetic antiandrogen bicalutamide also examined.
GPL570:
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Citation:
Nickols NG, Dervan PB. Suppression of androgen receptor-mediated gene expression by a sequence-specific DNA-binding polyamide. Proc Natl Acad Sci U S A 2007 Jun 19;104(25):10418-23. PMID: 17566103
